Annotations: 1GY5

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1gy5b_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	NTF2-like	Nuclear transport factor-2 (NTF2)	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1gy5a_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	NTF2-like	Nuclear transport factor-2 (NTF2)	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	NTF2-like	8039266	3000472	SCOP2B (2022-06-29)
A	SCOP2 Family	NTF2-like	8026887	4001021	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	NTF2-like	8039266	3000472	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	NTF2	e1gy5B1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: NTF2	ECOD (1.6)
A	NTF2	e1gy5A1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: NTF2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02136	Nuclear transport factor 2 (NTF2) domain (NTF2)	Nuclear transport factor 2 (NTF2) domain	This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	NUCLEAR TRANSPORT FACTOR 2	small GTPase binding protein binding binding enzyme binding GTPase binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity structural molecule activity structural constituent of nuclear pore identical protein binding	RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization cellular localization establishment of protein localization RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization cellular localization establishment of protein localization nucleocytoplasmic transport nuclear transport intracellular transport protein export from nucleus protein transport establishment of localization in cell cellular macromolecule localization cellular process nuclear export intracellular protein transport protein localization to nuclear pore protein localization to organelle protein localization to nucleus protein localization to nuclear envelope import into nucleus establishment of protein localization to organelle protein import into nucleus	membrane-bounded organelle nuclear outer membrane intracellular anatomical structure nuclear membrane membrane nucleus organelle outer membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle membrane-bounded organelle nuclear outer membrane intracellular anatomical structure nuclear membrane membrane nucleus organelle outer membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network nuclear envelope outer membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol organelle inner membrane nuclear inner membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B	IPR045875	Nuclear transport factor 2	Family
A, B	IPR018222	Nuclear transport factor 2, eukaryote	Domain
A, B	IPR002075	Nuclear transport factor 2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P61970	HIV infectious disease HIV Coinfection multiple sclerosis metabolic syndrome X

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.