1KF6

E. coli Quinol-Fumarate Reductase with Bound Inhibitor HQNO

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth M]	d1kf6m1	All alpha proteins	Spectrin repeat-like	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	Fumarate reductase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E [auth M]	d1kf6m2	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	Fumarate reductase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E [auth M]	d1kf6m3	Alpha and beta proteins (a+b)	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Fumarate reductase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1kf6a1	All alpha proteins	Spectrin repeat-like	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	Fumarate reductase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1kf6a2	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	Fumarate reductase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1kf6a3	Alpha and beta proteins (a+b)	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Fumarate reductase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1kf6b1	All alpha proteins	Globin-like	alpha-helical ferredoxin	Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain	Fumarate reductase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1kf6b2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	Fumarate reductase iron-sulfur protein, N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F [auth N]	d1kf6n1	All alpha proteins	Globin-like	alpha-helical ferredoxin	Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain	Fumarate reductase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F [auth N]	d1kf6n2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	Fumarate reductase iron-sulfur protein, N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G [auth O]	d1kf6o_	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Fumarate reductase respiratory complex transmembrane subunits	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	Fumarate reductase subunit FrdC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1kf6c_	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Fumarate reductase respiratory complex transmembrane subunits	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	Fumarate reductase subunit FrdC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1kf6d_	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Fumarate reductase respiratory complex transmembrane subunits	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	Fumarate reductase subunit FrdD	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H [auth P]	d1kf6p_	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Fumarate reductase respiratory complex transmembrane subunits	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	Fumarate reductase subunit FrdD	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth M]	SCOP2B Superfamily	Succinate dehydrogenase/fumarate reductase domain-like	8056076	3000054	SCOP2B (2022-06-29)
E [auth M]	SCOP2B Superfamily	L-aspartate oxidase C-terminal domain-like	8056077	3000021	SCOP2B (2022-06-29)
A	SCOP2 Family	L-aspartate oxidase-like	8056075	4000053	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Succinate dehydrogenase/fumarate reductase domain-like	8056076	3000054	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	L-aspartate oxidase C-terminal domain-like	8056077	3000021	SCOP2 (2022-06-29)
B	SCOP2 Family	Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain-like	8003618	4000221	SCOP2 (2022-06-29)
B	SCOP2 Family	2Fe-2S ferredoxin domains from multidomain proteins	8003621	4000241	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	alpha-helical ferredoxin	8003619	3000026	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	2Fe-2S ferredoxin-like	8003622	3000113	SCOP2 (2022-06-29)
F [auth N]	SCOP2B Superfamily	alpha-helical ferredoxin	8003619	3000026	SCOP2B (2022-06-29)
F [auth N]	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8003622	3000113	SCOP2B (2022-06-29)
G [auth O]	SCOP2B Superfamily	Fumarate reductase respiratory complex transmembrane subunits	8040234	3000518	SCOP2B (2022-06-29)
C	SCOP2 Family	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	8027855	4001916	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Fumarate reductase respiratory complex transmembrane subunits	8040234	3000518	SCOP2 (2022-06-29)
D	SCOP2 Family	Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)	8027844	4001916	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Fumarate reductase respiratory complex transmembrane subunits	8040223	3000518	SCOP2 (2022-06-29)
H [auth P]	SCOP2B Superfamily	Fumarate reductase respiratory complex transmembrane subunits	8040223	3000518	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth M]	Succ_DH_flav_C	e1kf6M1	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: Succ_DH_flav_C	ECOD (1.6)
E [auth M]	FAD_binding_2	e1kf6M2	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: FAD_binding_2	ECOD (1.6)
E [auth M]	FAD_binding_3_1st	e1kf6M3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: FAD_binding_3_1st	ECOD (1.6)
A	Succ_DH_flav_C	e1kf6A1	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: Succ_DH_flav_C	ECOD (1.6)
A	FAD_binding_2	e1kf6A2	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: FAD_binding_2	ECOD (1.6)
A	FAD_binding_3_1st	e1kf6A3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: FAD_binding_3_1st	ECOD (1.6)
B	Fer4_8	e1kf6B1	A: alpha arrays	X: alpha-helical ferredoxin-like	H: alpha-helical ferredoxin (From Topology)	T: alpha-helical ferredoxin	F: Fer4_8	ECOD (1.6)
B	Fer2_3	e1kf6B2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_3	ECOD (1.6)
F [auth N]	Fer4_8	e1kf6N1	A: alpha arrays	X: alpha-helical ferredoxin-like	H: alpha-helical ferredoxin (From Topology)	T: alpha-helical ferredoxin	F: Fer4_8	ECOD (1.6)
F [auth N]	Fer2_3	e1kf6N2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_3	ECOD (1.6)
G [auth O]	Fumarate_red_C	e1kf6O1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: Fumarate_red_C	ECOD (1.6)
C	Fumarate_red_C	e1kf6C1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: Fumarate_red_C	ECOD (1.6)
D	Fumarate_red_C	e1kf6D1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: Fumarate_red_C	ECOD (1.6)
H [auth P]	Fumarate_red_D	e1kf6P1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: Fumarate_red_D	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth M]	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
E [auth M]	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
E [auth M]	1.20.58.100	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
E [auth M]	4.10.80.40	Few Secondary Structures	Irregular	Rhinovirus 14, subunit 4	succinate dehydrogenase protein domain	CATH (4.3.0)
A	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
A	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
A	1.20.58.100	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	4.10.80.40	Few Secondary Structures	Irregular	Rhinovirus 14, subunit 4	succinate dehydrogenase protein domain	CATH (4.3.0)
B	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
B	1.10.1060.10	Mainly Alpha	Orthogonal Bundle	Fumarate Reductase Iron-sulfur Protein	Chain B, domain 2	CATH (4.3.0)
F [auth N]	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
F [auth N]	1.10.1060.10	Mainly Alpha	Orthogonal Bundle	Fumarate Reductase Iron-sulfur Protein	Chain B, domain 2	CATH (4.3.0)
G [auth O]	1.20.1300.10	Mainly Alpha	Up-down Bundle	3 helical TM bundles of succinate and fumarate reductases	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	CATH (4.3.0)
C	1.20.1300.10	Mainly Alpha	Up-down Bundle	3 helical TM bundles of succinate and fumarate reductases	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	CATH (4.3.0)
D	1.20.1300.10	Mainly Alpha	Up-down Bundle	3 helical TM bundles of succinate and fumarate reductases	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	CATH (4.3.0)
H [auth P]	1.20.1300.10	Mainly Alpha	Up-down Bundle	3 helical TM bundles of succinate and fumarate reductases	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth M]	PF02910	Fumarate reductase flavoprotein C-term (Succ_DH_flav_C)	Fumarate reductase flavoprotein C-term	This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.	Domain
A, E [auth M]	PF00890	FAD binding domain (FAD_binding_2)	FAD binding domain	-	Family
B, F [auth N]	PF13085	2Fe-2S iron-sulfur cluster binding domain (Fer2_3)	2Fe-2S iron-sulfur cluster binding domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.	Domain
B, F [auth N]	PF13237	4Fe-4S dicluster domain (Fer4_10)	4Fe-4S dicluster domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	Domain
C, G [auth O]	PF02300	Fumarate reductase subunit C (Fumarate_red_C)	Fumarate reductase subunit C	Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kD hy ...	Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kD hydrophobic subunit C.	Domain
D, H [auth P]	PF02313	Fumarate reductase subunit D (Fumarate_red_D)	Fumarate reductase subunit D	Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kD hy ...	Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kD hydrophobic subunit D.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth M]	FUMARATE REDUCTASE FLAVOPROTEIN	oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor succinate dehydrogenase (quinone) activity electron transfer activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process anaerobic electron transport chain cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain electron transport chain metabolic process generation of precursor metabolites and energy anaerobic respiration cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process anaerobic electron transport chain cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain electron transport chain metabolic process generation of precursor metabolites and energy anaerobic respiration fermentation organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular component organization or biogenesis cell projection assembly	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane
B, F [auth N]	FUMARATE REDUCTASE IRON-SULFUR PROTEIN	iron-sulfur cluster binding binding metal cluster binding small molecule binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity 4 iron, 4 sulfur cluster binding electron transfer activity iron-sulfur cluster binding binding metal cluster binding small molecule binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity 4 iron, 4 sulfur cluster binding electron transfer activity cation binding ion binding metal ion binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy anaerobic electron transport chain respiratory electron transport chain electron transport chain anaerobic respiration fermentation organelle assembly aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy anaerobic electron transport chain respiratory electron transport chain electron transport chain anaerobic respiration fermentation organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular component organization or biogenesis cell projection assembly	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol
C, G [auth O]	FUMARATE REDUCTASE 15 KDA HYDROPHOBIC PROTEIN	oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity	organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly anaerobic electron transport chain cellular respiration organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly anaerobic electron transport chain cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain electron transport chain metabolic process generation of precursor metabolites and energy anaerobic respiration fermentation	cell periphery cellular anatomical structure plasma membrane membrane
D, H [auth P]	FUMARATE REDUCTASE 13 KDA HYDROPHOBIC PROTEIN	oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity	organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly anaerobic electron transport chain cellular respiration organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly anaerobic electron transport chain cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain electron transport chain metabolic process generation of precursor metabolites and energy anaerobic respiration oxoacid metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process small molecule metabolic process fumarate metabolic process organic acid metabolic process fermentation	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth M]	IPR015939	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal	Domain
A, E [auth M]	IPR003952	Fumarate reductase/succinate dehydrogenase, FAD-binding site	Binding Site
A, E [auth M]	IPR037099	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily	Homologous Superfamily
A, E [auth M]	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A, E [auth M]	IPR003953	FAD-dependent oxidoreductase 2, FAD binding domain	Domain
A, E [auth M]	IPR030664	FAD-dependent oxidoreductase SdhA/FrdA/AprA	Family
A, E [auth M]	IPR005884	Fumarate reductase, flavoprotein subunit	Family
A, E [auth M]	IPR027477	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily	Homologous Superfamily
A, E [auth M]	IPR014006	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	Family
B, F [auth N]	IPR025192	Succinate dehydogenase/fumarate reductase N-terminal	Domain
B, F [auth N]	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
B, F [auth N]	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
B, F [auth N]	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
B, F [auth N]	IPR004489	Succinate dehydrogenase/fumarate reductase iron-sulphur protein	Family
B, F [auth N]	IPR009051	Alpha-helical ferredoxin	Homologous Superfamily
B, F [auth N]	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
B, F [auth N]	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
B, F [auth N]	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
C, G [auth O]	IPR034804	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	Homologous Superfamily
C, G [auth O]	IPR003510	Fumarate reductase, subunit C	Family
D, H [auth P]	IPR034804	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	Homologous Superfamily
D, H [auth P]	IPR003418	Fumarate reductase, subunit D	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E [auth M] A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex II superfamily	Succinate dehydrogenase/fumarate reductase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E [auth M] A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E [auth M] A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E [auth M] A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Electron Transport Chain Complexes: Complex II	Native Fumarate Reductase Complex