1N9P

Crystal Structure of the Cytoplasmic Domain of G-protein Activated Inward Rectifier Potassium Channel 1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n9pa_	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	Cytoplasmic domain of inward rectifier potassium channel	G protein-gated inward rectifier Girk1	house mouse (Mus musculus ) [TaxId: 10090 ], house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Cytoplasmic domain of inward rectifier potassium channel	8055022	4000319	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	E set domains	8055023	3000070	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IRK_C	e1n9pA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IRK_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.1400	Mainly Beta	Sandwich	Immunoglobulin-like	G protein-activated inward rectifier potassium channel 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17655	Inward rectifier potassium channel C-terminal domain (IRK_C)	Inward rectifier potassium channel C-terminal domain	This cytoplasmic C-terminal domain has an Ig fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	G protein-activated inward rectifier potassium channel 1	passive transmembrane transporter activity gated channel activity monoatomic ion channel activity voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity ligand-gated channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity ligand-gated channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity ligand-gated monoatomic cation channel activity inward rectifier potassium channel activity potassium ion transmembrane transporter activity potassium channel activity voltage-gated monoatomic cation channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity voltage-gated potassium channel activity G-protein activated inward rectifier potassium channel activity metal ion transmembrane transporter activity	response to electrical stimulus response to stimulus response to abiotic stimulus transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport response to electrical stimulus response to stimulus response to abiotic stimulus transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport regulation of localization regulation of biological process regulation of cellular process regulation of transport regulation of monoatomic ion transport biological regulation regulation of monoatomic ion transmembrane transport regulation of transmembrane transport import into cell import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane potassium ion import across plasma membrane	cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule cell surface external side of plasma membrane side of membrane voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule cell surface external side of plasma membrane side of membrane voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex I(KACh) inward rectifier potassium channel complex transmembrane transporter complex inward rectifier potassium channel complex monoatomic ion channel complex parallel fiber to Purkinje cell synapse synapse cell junction excitatory synapse presynapse presynaptic membrane plasma membrane region synaptic membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041647	Inward rectifier potassium channel, C-terminal	Domain
A	IPR040445	Potassium channel, inwardly rectifying, transmembrane domain	Domain
A	IPR016449	Potassium channel, inwardly rectifying, Kir	Family
A	IPR003274	Potassium channel, inwardly rectifying, Kir3.1	Family
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic	Homologous Superfamily

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	GIRK1 (Kir3.1) cytoplasmic domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.