1QZ2

Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1qz2b1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	FKBP52 (FKBP4), C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1qz2b2	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FKBP52, N-terminal domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1qz2b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1qz2c1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	FKBP52 (FKBP4), C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1qz2c2	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FKBP52, N-terminal domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1qz2c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1qz2a1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	FKBP52 (FKBP4), C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1qz2a2	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FKBP52, N-terminal domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1qz2a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	TPR-like	8038046	3001345	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Rotamase-like	8038433	3000622	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TPR-like	8038046	3001345	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Rotamase-like	8038433	3000622	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Rotamase-like	8038433	3000622	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	TPR-like	8038046	3001345	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	TPR_11_8	e1qz2B4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_8	ECOD (1.6)
B	FKBP_C	e1qz2B3	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
C	TPR_11_8	e1qz2C4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_8	ECOD (1.6)
C	FKBP_C	e1qz2C3	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
A	TPR_11_8	e1qz2A4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_8	ECOD (1.6)
A	FKBP_C	e1qz2A3	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
B	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
C	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
C	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
A	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00515	Tetratricopeptide repeat (TPR_1)	Tetratricopeptide repeat	-	Repeat
A, B, C	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	FK506-binding protein 4	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding nuclear glucocorticoid receptor binding DNA-binding transcription factor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity phosphoprotein binding FK506 binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding nuclear glucocorticoid receptor binding DNA-binding transcription factor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity phosphoprotein binding FK506 binding amide binding organic cyclic compound binding macrolide binding copper-dependent protein binding heat shock protein binding RNA binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity adenyl ribonucleotide binding adenyl nucleotide binding ATP binding cytoskeletal protein binding tau protein binding	protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus regulation of biological process response to endogenous stimulus biological regulation cellular response to organic cyclic compound cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization microtubule cytoskeleton organization negative regulation of biological process cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization negative regulation of supramolecular fiber organization cellular component organization or biogenesis protein polymerization negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization protein-containing complex organization negative regulation of cytoskeleton organization regulation of microtubule-based process negative regulation of microtubule polymerization microtubule polymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly organelle organization negative regulation of organelle organization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization developmental process multicellular organismal process reproductive system development prostate gland development reproductive process gland development animal organ development urogenital system development developmental process involved in reproduction multicellular organism development anatomical structure development reproductive structure development system development chaperone-mediated protein folding localization transport copper ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport male sex differentiation sex differentiation protein-containing complex localization regulation of neuron projection development cellular developmental process cell projection organization cell development neuron projection development neurogenesis neuron differentiation cell differentiation negative regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization multi-multicellular organism process female pregnancy embryo implantation multi-organism reproductive process steroid hormone receptor complex assembly	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle growth cone axon cell projection distal axon neuron projection axonal growth cone membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body polymeric cytoskeletal fiber intracellular membraneless organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
D [auth G], E [auth H]	5-mer peptide from Heat shock protein HSP 90	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding histone deacetylase binding protein binding enzyme binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding heat shock protein binding adenyl ribonucleotide binding nucleotide binding RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding histone deacetylase binding protein binding enzyme binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding heat shock protein binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding tau protein binding cell adhesion molecule binding cadherin binding enzyme regulator activity molecular function regulator activity nitric-oxide synthase regulator activity protein kinase regulator activity kinase regulator activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding histone methyltransferase binding molecular function inhibitor activity receptor ligand inhibitor activity protein dimerization activity identical protein binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity ATP-dependent protein binding kinase binding unfolded protein binding protein homodimerization activity protein kinase binding TPR domain binding protein domain specific binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity peptide binding DNA polymerase binding disordered domain specific binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process regulation of protein stability regulation of biological quality protein stabilization ribonucleoprotein complex biogenesis telomerase holoenzyme complex assembly protein-containing complex organization protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein folding primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation developmental process placenta development animal organ development anatomical structure development response to stimulus response to topologically incorrect protein response to stress response to unfolded protein cellular response to stimulus cellular response to heat cellular response to stress response to heat response to abiotic stimulus response to temperature stimulus response to interleukin-4 response to peptide response to chemical response to cytokine cellular response to cytokine stimulus cellular response to interleukin-4 regulation of developmental process cellular developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process negative regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein metabolic process negative regulation of metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to cell surface localization protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization positive regulation of protein localization regulation of protein localization to cell surface supramolecular fiber organization telomere maintenance via telomerase telomere organization chromosome organization DNA metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening telomere maintenance nucleic acid biosynthetic process organelle organization DNA biosynthetic process chaperone-mediated protein complex assembly positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction cell communication regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death chaperone-mediated protein folding virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of protein modification process regulation of post-translational protein modification regulation of protein ubiquitination protein ubiquitination macromolecule modification regulation of protein modification by small protein conjugation or removal protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal cell cycle regulation of cell cycle	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol dendrite terminus axon neuron projection plasma membrane bounded cell projection growth cone somatodendritic compartment cell projection distal axon dendritic growth cone dendrite dendritic tree site of polarized growth intracellular organelle membraneless organelle dynein axonemal particle intracellular membraneless organelle protein-containing complex protein folding chaperone complex intracellular protein-containing complex perinuclear region of cytoplasm cell body neuronal cell body mitochondrion intracellular membrane-bounded organelle axonal growth cone pigment granule intracellular vesicle melanosome cytoplasmic vesicle cell surface cell periphery plasma membrane membrane-enclosed lumen ficolin-1-rich granule endomembrane system intracellular organelle lumen organelle lumen ficolin-1-rich granule lumen secretory granule secretory vesicle nucleus nucleoplasm nuclear lumen HSP90-CDC37 chaperone complex aryl hydrocarbon receptor complex receptor complex vesicle lumen cytoplasmic vesicle lumen secretory granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A, B, C	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B, C	IPR019734	Tetratricopeptide repeat	Repeat
A, B, C	IPR050754	Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like	Family
A, B, C	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain
A, B, C	IPR013105	Tetratricopeptide repeat 2	Repeat
D [auth G], E [auth H]	IPR003594	Histidine kinase/HSP90-like ATPase domain	Domain
D [auth G], E [auth H]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
D [auth G], E [auth H]	IPR001404	Heat shock protein Hsp90 family	Family
D [auth G], E [auth H]	IPR019805	Heat shock protein Hsp90, conserved site	Conserved Site
D [auth G], E [auth H]	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
D [auth G], E [auth H]	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
D [auth G], E [auth H]	IPR037196	HSP90, C-terminal domain	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q02790	subependymal giant cell astrocytoma breast cancer ductal breast carcinoma in situ lung cancer malignant glioma non-small cell lung carcinoma Prevention of Cardiac Transplant Rejection rheumatoid arthritis breast carcinoma interstitial cystitis lung carcinoma malignant mesothelioma ovarian cancer dry eye syndrome invasive ductal breast carcinoma subependymal giant cell astrocytoma breast cancer ductal breast carcinoma in situ lung cancer malignant glioma non-small cell lung carcinoma Prevention of Cardiac Transplant Rejection rheumatoid arthritis breast carcinoma interstitial cystitis lung carcinoma malignant mesothelioma ovarian cancer dry eye syndrome invasive ductal breast carcinoma major depressive disorder mucocutaneous lymph node syndrome pilocytic astrocytoma
D [auth G], E [auth H]	Pharos: P08238	prostate cancer HIV infectious disease ovarian cancer subependymal giant cell astrocytoma breast cancer gastric carcinoma interstitial cystitis large cell medulloblastoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm Prostatic Neoplasms exocrine pancreatic carcinoma interstitial lung disease prostate cancer HIV infectious disease ovarian cancer subependymal giant cell astrocytoma breast cancer gastric carcinoma interstitial cystitis large cell medulloblastoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm Prostatic Neoplasms exocrine pancreatic carcinoma interstitial lung disease lung adenocarcinoma malignant ependymoma myopathy osteosarcoma plasma cell myeloma rheumatoid arthritis gastric cancer invasive ductal breast carcinoma lung cancer malignant glioma non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.