1RO7
Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analogue, CMP-3FNeuAc.
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
| Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
|---|---|---|---|---|---|
| A | SCOP2 Family | Alpha-2, 3/8-sialyltransferase CstII | 8028400 | 4001079 | SCOP2 (2022-06-29) |
| A | SCOP2 Superfamily | Sialyltransferase/TPK catalytic domain-like | 8040779 | 3000683 | SCOP2 (2022-06-29) |
| D | SCOP2B Superfamily | Sialyltransferase/TPK catalytic domain-like | 8040779 | 3000683 | SCOP2B (2022-06-29) |
| B | SCOP2B Superfamily | Sialyltransferase/TPK catalytic domain-like | 8040779 | 3000683 | SCOP2B (2022-06-29) |
| C | SCOP2B Superfamily | Sialyltransferase/TPK catalytic domain-like | 8040779 | 3000683 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
| Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
|---|---|---|---|---|---|---|---|---|
| A | CST-I | e1ro7A1 | A: a/b three-layered sandwiches | X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology) | H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology) | T: Alpha-2,3/8-sialyltransferase CstII-related | F: CST-I | ECOD (1.6) |
| D | CST-I | e1ro7D1 | A: a/b three-layered sandwiches | X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology) | H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology) | T: Alpha-2,3/8-sialyltransferase CstII-related | F: CST-I | ECOD (1.6) |
| B | CST-I | e1ro7B1 | A: a/b three-layered sandwiches | X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology) | H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology) | T: Alpha-2,3/8-sialyltransferase CstII-related | F: CST-I | ECOD (1.6) |
| C | CST-I | e1ro7C1 | A: a/b three-layered sandwiches | X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology) | H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology) | T: Alpha-2,3/8-sialyltransferase CstII-related | F: CST-I | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
| Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
|---|---|---|---|---|---|---|
| A | 3.90.1480.10 | Alpha Beta | Alpha-Beta Complex | sialyltransferase cstii, chain A | Alpha-2,3-sialyltransferase | CATH (4.3.0) |
| D | 3.90.1480.10 | Alpha Beta | Alpha-Beta Complex | sialyltransferase cstii, chain A | Alpha-2,3-sialyltransferase | CATH (4.3.0) |
| B | 3.90.1480.10 | Alpha Beta | Alpha-Beta Complex | sialyltransferase cstii, chain A | Alpha-2,3-sialyltransferase | CATH (4.3.0) |
| C | 3.90.1480.10 | Alpha Beta | Alpha-Beta Complex | sialyltransferase cstii, chain A | Alpha-2,3-sialyltransferase | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
| Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
|---|---|---|---|---|
| alpha-2,3/8-sialyltransferase | - | - |
InterPro: Protein Family Classification InterPro Database Homepage
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage
| Chains | Enzyme Name | Description | Catalytic Residues |
|---|---|---|---|
| alpha-2,3-sialyltransferase M-CSA #840 | Sialyltransferase (CstII) from Campylobacter jejuni catalyses the transfer of the sialic acid moiety from cytidine-5'-monophospho-N-acetyl-neuramic acid (CMP-NeuAc) to the terminal positions of glycoconjugates. The products play critical roles in recognition and adherence. Campylobacter jejuni has been shown to express variable cell surface carbohydrate mimics of human gangliosides that are associated with virulence. | EC: 2.4.99 (PDB Primary Data) |
