1UW6

X-ray structure of acetylcholine binding protein (AChBP) in complex with nicotine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uw6a_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
B	d1uw6b_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
C	d1uw6c_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
D	d1uw6d_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
E	d1uw6e_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
F	d1uw6f_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
G	d1uw6g_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
H	d1uw6h_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
I	d1uw6i_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
J	d1uw6j_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
K	d1uw6k_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
L	d1uw6l_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
M	d1uw6m_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
N	d1uw6n_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
O	d1uw6o_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
P	d1uw6p_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
Q	d1uw6q_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
R	d1uw6r_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
S	d1uw6s_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
T	d1uw6t_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	nicotinic receptor ligand binding domain-like	8022830	4003166	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Neur_chan_LBD	e1uw6A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
B	Neur_chan_LBD	e1uw6B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
C	Neur_chan_LBD	e1uw6C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
D	Neur_chan_LBD	e1uw6D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
E	Neur_chan_LBD	e1uw6E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
F	Neur_chan_LBD	e1uw6F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
G	Neur_chan_LBD	e1uw6G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
H	Neur_chan_LBD	e1uw6H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
I	Neur_chan_LBD	e1uw6I1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
J	Neur_chan_LBD	e1uw6J1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
K	Neur_chan_LBD	e1uw6K1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
L	Neur_chan_LBD	e1uw6L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
M	Neur_chan_LBD	e1uw6M1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
N	Neur_chan_LBD	e1uw6N1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
O	Neur_chan_LBD	e1uw6O1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
P	Neur_chan_LBD	e1uw6P1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
Q	Neur_chan_LBD	e1uw6Q1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
R	Neur_chan_LBD	e1uw6R1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
S	Neur_chan_LBD	e1uw6S1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
T	Neur_chan_LBD	e1uw6T1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
B	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
C	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
D	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
E	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
F	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
G	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
H	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
I	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
J	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
K	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
L	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
M	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
N	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
O	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
P	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
Q	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
R	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
S	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
T	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	ACETYLCHOLINE-BINDING PROTEIN	ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	-	cellular anatomical structure synaptic cleft extracellular region membrane postsynapse synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR006201	Neurotransmitter-gated ion-channel	Family

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1UW6

X-ray structure of acetylcholine binding protein (AChBP) in complex with nicotine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage