1V3V | pdb_00001v3v

Crystal structure of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complexed with NADP and 15-oxo-PGE2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1v3va1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase	domestic guinea pig (Cavia porcellus ) [TaxId: 10141 ],	SCOPe (2.08)
A	d1v3va2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase	domestic guinea pig (Cavia porcellus ) [TaxId: 10141 ],	SCOPe (2.08)
A	d1v3va3	Artifacts	Tags	Tags	Tags	N-terminal Tags	domestic guinea pig (Cavia porcellus ) [TaxId: 10141 ],	SCOPe (2.08)
B	d1v3vb1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase	domestic guinea pig (Cavia porcellus ) [TaxId: 10141 ],	SCOPe (2.08)
B	d1v3vb2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase	domestic guinea pig (Cavia porcellus ) [TaxId: 10141 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Quinone oxidoreductase-like	8057558	4000090	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Zinc-containing alcohol dehydrogenase-like	8057560	3000040	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GroES-like	8057559	3000002	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	GroES-like	8057559	3000002	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8057560	3000040	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ADH_N_2	e1v3vA1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N_2	ECOD (1.6)
A	ADH_zinc_N	e1v3vA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
B	ADH_N_2	e1v3vB1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N_2	ECOD (1.6)
B	ADH_zinc_N	e1v3vB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00107	Zinc-binding dehydrogenase (ADH_zinc_N)	Zinc-binding dehydrogenase		Domain
A, B	PF16884	N-terminal domain of oxidoreductase (ADH_N_2)	N-terminal domain of oxidoreductase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase	leukotriene B4 12-hydroxy dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors catalytic activity 2-alkenal reductase (NADPH) activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2-alkenal reductase [NAD(P)+] activity oxidoreductase activity, acting on the CH-CH group of donors 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13-lipoxin reductase activity	fatty acid metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipoxin metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process fatty acid derivative metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipoxin A4 metabolic process fatty acid metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipoxin metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process fatty acid derivative metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipoxin A4 metabolic process lipid metabolic process prostaglandin metabolic process icosanoid metabolic process prostanoid metabolic process leukotriene metabolic process leukotriene B4 metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR045010	Medium-chain dehydrogenase/reductase	Family
A, B	IPR014190	Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase	Family
A, B	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B	IPR041694	Oxidoreductase, N-terminal domain	Domain
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR013149	Alcohol dehydrogenase-like, C-terminal	Domain
A, B	IPR020843	Enoylreductase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.