1VYH

PAF-AH Holoenzyme: Lis1/Alfa2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1vyha1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1vyhe1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1vyhf1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d1vyhi1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d1vyhj1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M	d1vyhm1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N	d1vyhn1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
Q	d1vyhq1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1vyhb1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
R	d1vyhr1	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1vyhc1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d1vyhd1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d1vyhg1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H	d1vyhh1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
K	d1vyhk1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
L	d1vyhl1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
O	d1vyho1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
P	d1vyhp1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
S	d1vyhs1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
T	d1vyht1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Platelet-activating factor acetylhydrolase IB subunit alpha	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2 Family	WD40-repeat	8020049	4002744	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	WD40 repeat-like	8032429	3001694	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	WD40 repeat-like	8032429	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lipase_GDSL_2	e1vyhA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
E	Lipase_GDSL_2	e1vyhE1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
F	Lipase_GDSL_2	e1vyhF1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
I	Lipase_GDSL_2	e1vyhI1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
J	Lipase_GDSL_2	e1vyhJ1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
M	Lipase_GDSL_2	e1vyhM1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
N	Lipase_GDSL_2	e1vyhN1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
Q	Lipase_GDSL_2	e1vyhQ1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
B	Lipase_GDSL_2	e1vyhB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
R	Lipase_GDSL_2	e1vyhR1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)
C	ANAPC4_WD40_12	e1vyhC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_12	ECOD (1.6)
D	ANAPC4_WD40_7	e1vyhD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
G	ANAPC4_WD40_7	e1vyhG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
H	ANAPC4_WD40_7	e1vyhH1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
K	ANAPC4_WD40_7	e1vyhK1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
L	ANAPC4_WD40_7	e1vyhL1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
O	ANAPC4_WD40_7	e1vyhO1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
P	ANAPC4_WD40_7	e1vyhP1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
S	ANAPC4_WD40_7	e1vyhS1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
T	ANAPC4_WD40_7	e1vyhT1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
E	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
F	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
I	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
J	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
M	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
N	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
Q	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
B	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
R	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
D	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
G	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
H	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
K	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
L	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
O	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
P	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
S	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
T	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E, F, I A, B, E, F, I, J, M, N, Q, R	PF13472	GDSL-like Lipase/Acylhydrolase family (Lipase_GDSL_2)	GDSL-like Lipase/Acylhydrolase family	This family of presumed lipases and related enzymes are similar to Pfam:PF00657.	Domain
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E, F, I A, B, E, F, I, J, M, N, Q, R	PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB BETA SUBUNIT	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein-containing complex binding hydrolase activity, acting on ester bonds 1-alkyl-2-acetylglycerophosphocholine esterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity protein heterodimerization activity platelet-activating factor acetyltransferase activity acetyltransferase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein-containing complex binding hydrolase activity, acting on ester bonds 1-alkyl-2-acetylglycerophosphocholine esterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity protein heterodimerization activity platelet-activating factor acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity	lipid catabolic process catabolic process metabolic process cellular process primary metabolic process lipid metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation lipid catabolic process catabolic process metabolic process cellular process primary metabolic process lipid metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation positive regulation of autophagy regulation of biological process regulation of cellular process macroautophagy autophagy biological regulation positive regulation of biological process regulation of catabolic process regulation of autophagy positive regulation of catabolic process positive regulation of metabolic process regulation of macroautophagy positive regulation of macroautophagy process utilizing autophagic mechanism regulation of metabolic process positive regulation of cellular process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen extracellular region extracellular exosome extracellular vesicle extracellular organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen endomembrane system cytoplasmic vesicle secretory granule secretory vesicle cytoplasm cytosol cell periphery plasma membrane membrane fibrillar center ficolin-1-rich granule ficolin-1-rich granule lumen protein-containing complex catalytic complex 1-alkyl-2-acetylglycerophosphocholine esterase complex
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB ALPHA SUBUNIT	phosphoprotein binding protein binding binding cytoskeletal protein binding microtubule binding tubulin binding dynein intermediate chain binding identical protein binding protein heterodimerization activity protein dimerization activity protein-containing complex binding dynein complex binding	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process nervous system development generation of neurons neurogenesis developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development cell differentiation cellular process neural precursor cell proliferation system development forebrain development glial cell migration telencephalon glial cell migration cerebral cortex development telencephalon cell migration forebrain cell migration gliogenesis cell migration cell motility layer formation in cerebral cortex cerebral cortex cell migration head development brain development cerebral cortex radially oriented cell migration pallium development anatomical structure morphogenesis central nervous system development anatomical structure formation involved in morphogenesis cerebral cortex radial glia-guided migration telencephalon development central nervous system neuron differentiation neuron differentiation cerebral cortex neuron differentiation establishment of organelle localization cellular localization transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration axon extension positive regulation of nervous system development regulation of growth regulation of cellular process axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron projection morphogenesis positive regulation of cell projection organization regulation of biological quality positive regulation of developmental growth regulation of biological process regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process plasma membrane bounded cell projection morphogenesis positive regulation of biological process cell development cell growth cell morphogenesis regulation of axon extension cellular component organization regulation of nervous system development regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension cellular component organization or biogenesis positive regulation of cellular process positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth biological regulation growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling response to cytokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to cytokine stimulus signal transduction regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway response to peptide regulation of response to cytokine stimulus regulation of response to stimulus response to chemical regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling inner ear receptor cell development epidermis development epithelial cell differentiation hair cell differentiation mechanoreceptor differentiation epithelium development epidermal cell differentiation inner ear auditory receptor cell differentiation tissue development inner ear receptor cell differentiation auditory receptor cell development organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization negative regulation of biological process negative regulation of cellular process negative regulation of cell projection organization negative regulation of cellular component organization negative regulation of neuron projection development membrane organization cellular component disassembly nuclear membrane disassembly membrane disassembly nuclear membrane organization nucleus organization nuclear envelope organization endomembrane system organization trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling microtubule organizing center organization microtubule cytoskeleton organization microtubule-based process spindle localization establishment or maintenance of cell polarity mitotic cell cycle establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation cell cycle microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of cell polarity mitotic cell cycle process establishment of mitotic spindle orientation system process nervous system process transmission of nerve impulse intracellular signal transduction JNK cascade intracellular signaling cassette MAPK cascade maintenance of centrosome location centrosome localization microtubule organizing center localization maintenance of organelle location maintenance of location in cell maintenance of location reelin-mediated signaling pathway protein localization establishment of protein localization nitrogen compound transport secretion establishment of protein localization to extracellular region export from cell protein secretion protein localization to extracellular region secretion by cell protein transport cellular macromolecule localization macromolecule localization myeloid leukocyte differentiation hemopoiesis osteoclast development skeletal system development myeloid cell differentiation osteoclast differentiation bone cell development myeloid cell development bone development leukocyte differentiation stem cell division cell division spermatid development spermatid differentiation sexual reproduction spermatogenesis cellular component assembly involved in morphogenesis reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation cellular component biogenesis vesicle organization cellular anatomical entity morphogenesis cellular component assembly organelle assembly secretory granule organization multicellular organismal reproductive process male gamete generation germ cell development acrosome assembly postsynapse organization regulation of postsynapse organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization establishment of planar polarity morphogenesis of an epithelium microtubule cytoskeleton organization involved in establishment of planar polarity tissue morphogenesis establishment of tissue polarity morphogenesis of a polarized epithelium positive regulation of dendritic spine morphogenesis positive regulation of dendritic spine development regulation of cell morphogenesis regulation of dendrite morphogenesis dendritic spine morphogenesis dendritic spine development dendritic spine organization positive regulation of cell morphogenesis regulation of dendrite development regulation of dendritic spine development dendrite development positive regulation of neuron projection development dendrite morphogenesis positive regulation of dendrite morphogenesis regulation of dendritic spine morphogenesis neuron projection organization hippocampus development limbic system development adult locomotory behavior behavior adult behavior locomotory behavior corpus callosum development corpus callosum morphogenesis central nervous system neuron development central nervous system projection neuron axonogenesis central nervous system neuron axonogenesis cortical cytoskeleton organization cytoplasmic microtubule organization cortical microtubule organization supramolecular fiber organization vesicle cytoskeletal trafficking vesicle localization organelle transport along microtubule establishment of vesicle localization vesicle transport along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement brain morphogenesis animal organ morphogenesis ameboidal-type cell migration neuromuscular process neuromuscular process controlling balance negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of JNK cascade regulation of intracellular signal transduction negative regulation of response to stimulus regulation of JNK cascade regulation of MAPK cascade negative regulation of signal transduction negative regulation of MAPK cascade regulation of cytoskeleton organization regulation of microtubule-based process regulation of organelle organization regulation of microtubule cytoskeleton organization establishment of planar polarity of embryonic epithelium lipid catabolic process catabolic process metabolic process primary metabolic process lipid metabolic process learning or memory cognition neuron migration interneuron migration leukocyte migration immune system process myeloid leukocyte migration radial glia-guided pyramidal neuron migration microtubule sliding regulation of embryonic development embryo development positive regulation of embryonic development retrograde axonal transport axonal transport axo-dendritic transport positive regulation of cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle regulation of cell cycle establishment of centrosome localization	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane cell leading edge membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane cell leading edge protein-containing complex intracellular membraneless organelle cytoskeleton membraneless organelle microtubule associated complex kinesin complex microtubule cytoskeleton cytoplasm synapse cell junction glutamatergic synapse perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body cell projection stereocilium actin-based cell projection stereocilium bundle neuron projection cluster of actin-based cell projections plasma membrane bounded cell projection neuron projection cytoplasm axon axon cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm growth cone distal axon central region of growth cone site of polarized growth cell periphery cell cortex vesicle centrosome microtubule organizing center cilium motile cilium polymeric cytoskeletal fiber spindle aster astral microtubule spindle microtubule cytoplasmic microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex catalytic complex 1-alkyl-2-acetylglycerophosphocholine esterase complex chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E, F, I A, B, E, F, I, J, M, N, Q, R	IPR036514	SGNH hydrolase superfamily	Homologous Superfamily
A, B, E, F, I A, B, E, F, I, J, M, N, Q, R	IPR013830	SGNH hydrolase-type esterase domain	Domain
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR019775	WD40 repeat, conserved site	Conserved Site
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR006594	LIS1 homology motif	Conserved Site
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR020472	G-protein beta WD-40 repeat	Repeat
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR037190	LIS1, N-terminal	Homologous Superfamily
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR050349	WD repeat LIS1/nudF dynein regulation	Family
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR001680	WD40 repeat	Repeat
C, D, G, H, K C, D, G, H, K, L, O, P, S, T	IPR017252	Dynein regulator LIS1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, E, F, I A, B, E, F, I, J, M, N, Q, R	Pharos: P68402	juvenile dermatomyositis myopathy tuberculosis lung cancer ovarian cancer malignant pancreatic neoplasm pancreatic ductal adenocarcinoma