2IZX

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2izxa_	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2izxb_	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Dpy-30/Rlla-like	8077008	3001874	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RIIa	e2izxA1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)
B	RIIa	e2izxB1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02197	Regulatory subunit of type II PKA R-subunit (RIIa)	Regulatory subunit of type II PKA R-subunit	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C	AKAP-IS	-	-	-
A, B	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT	protein binding binding protein domain specific binding enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity cAMP-dependent protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity cAMP-dependent protein kinase inhibitor activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity protein binding binding protein domain specific binding enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity cAMP-dependent protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity cAMP-dependent protein kinase inhibitor activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity adenyl ribonucleotide binding cyclic nucleotide binding nucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding cAMP binding adenyl nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding protein kinase A catalytic subunit binding protein kinase A binding kinase binding protein kinase binding	cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction negative regulation of cAMP/PKA signal transduction intracellular signal transduction negative regulation of cell communication cell communication cAMP/PKA signal transduction regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction negative regulation of cAMP/PKA signal transduction intracellular signal transduction negative regulation of cell communication cell communication cAMP/PKA signal transduction regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation negative regulation of signal transduction regulation of cAMP/PKA signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of protein modification process regulation of protein phosphorylation regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol cell periphery plasma membrane protein-containing complex ciliary base cell projection cilium plasma membrane bounded cell projection protein kinase complex transferase complex, transferring phosphorus-containing groups catalytic complex transferase complex intracellular protein-containing complex nucleotide-activated protein kinase complex cAMP-dependent protein kinase complex serine/threonine protein kinase complex membrane microdomain membrane raft plasma membrane raft plasma membrane region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR050503	cAMP-dependent kinase regulatory chain	Family
A, B	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A, B	IPR018488	Cyclic nucleotide-binding, conserved site	Conserved Site
A, B	IPR003117	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	Domain
A, B	IPR000595	Cyclic nucleotide-binding domain	Domain
A, B	IPR012198	cAMP-dependent protein kinase regulatory subunit	Family
A, B	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P13861	anorexia nervosa large cell medulloblastoma osteosarcoma psoriasis atypical teratoid rhabdoid tumor medulloblastoma ovarian cancer subependymal giant cell astrocytoma endogenous depression myocardial infarction pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.