2PI8

Crystal structure of E. coli MltA with bound chitohexaose

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2pi8b_	All beta proteins	Double psi beta-barrel	Barwin-like endoglucanases	MLTA-like	Membrane-bound lytic murein transglycosylase A, MLTA	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
A	d2pi8a_	All beta proteins	Double psi beta-barrel	Barwin-like endoglucanases	MLTA-like	Membrane-bound lytic murein transglycosylase A, MLTA	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d2pi8c_	All beta proteins	Double psi beta-barrel	Barwin-like endoglucanases	MLTA-like	Membrane-bound lytic murein transglycosylase A, MLTA	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d2pi8d_	All beta proteins	Double psi beta-barrel	Barwin-like endoglucanases	MLTA-like	Membrane-bound lytic murein transglycosylase A, MLTA	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Barwin-like endoglucanases	8033465	3001124	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Barwin-like endoglucanases	8033465	3001124	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Barwin-like endoglucanases	8033465	3001124	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Barwin-like endoglucanases	8033465	3001124	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	3D	e2pi8B3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: 3D	ECOD (1.6)
B	MltA	e2pi8B4	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: MltA	ECOD (1.6)
A	3D	e2pi8A3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: 3D	ECOD (1.6)
A	MltA	e2pi8A4	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: MltA	ECOD (1.6)
C	3D	e2pi8C3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: 3D	ECOD (1.6)
C	MltA	e2pi8C4	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: MltA	ECOD (1.6)
D	3D	e2pi8D3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: 3D	ECOD (1.6)
D	MltA	e2pi8D4	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: MltA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.40.10	Mainly Beta	Beta Barrel	Barwin-like endoglucanases	RlpA-like domain	CATH (4.3.0)
B	2.40.240.50	Mainly Beta	Beta Barrel	Ribosomal Protein L25	Chain P	CATH (4.3.0)
A	2.40.40.10	Mainly Beta	Beta Barrel	Barwin-like endoglucanases	RlpA-like domain	CATH (4.3.0)
A	2.40.240.50	Mainly Beta	Beta Barrel	Ribosomal Protein L25	Chain P	CATH (4.3.0)
C	2.40.40.10	Mainly Beta	Beta Barrel	Barwin-like endoglucanases	RlpA-like domain	CATH (4.3.0)
C	2.40.240.50	Mainly Beta	Beta Barrel	Ribosomal Protein L25	Chain P	CATH (4.3.0)
D	2.40.40.10	Mainly Beta	Beta Barrel	Barwin-like endoglucanases	RlpA-like domain	CATH (4.3.0)
D	2.40.240.50	Mainly Beta	Beta Barrel	Ribosomal Protein L25	Chain P	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03562	MltA specific insert domain (MltA)	MltA specific insert domain	This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme [1]. This domain may be involved in peptidoglycan binding.	Domain
A, B, C, D	PF06725	3D domain (3D)	3D domain	This short presumed domain contains three conserved aspartate residues, hence the name 3D. It has been shown to be part of the catalytic double psi beta barrel domain of MltA [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Membrane-bound lytic murein transglycosylase A	lytic transglycosylase activity peptidoglycan muralytic activity lyase activity catalytic activity carbon-oxygen lyase activity, acting on polysaccharides carbon-oxygen lyase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity	glycosaminoglycan metabolic process aminoglycan metabolic process peptidoglycan metabolic process carbohydrate derivative metabolic process metabolic process cellular process macromolecule metabolic process carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process cellular component organization glycosaminoglycan metabolic process aminoglycan metabolic process peptidoglycan metabolic process carbohydrate derivative metabolic process metabolic process cellular process macromolecule metabolic process carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process cellular component organization cell wall organization or biogenesis cell wall organization cellular component organization or biogenesis external encapsulating structure organization peptidoglycan turnover	cellular anatomical structure outer membrane-bounded periplasmic space cell envelope periplasmic space cell periphery cell outer membrane external encapsulating structure membrane outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR010611	3D domain	Domain
A, B, C, D	IPR005300	Lytic transglycosylase MltA, domain B	Domain
A, B, C, D	IPR036908	RlpA-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR026044	Membrane-bound lytic murein transglycosylase A	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.