3QZ1

Crystal Structure of Bovine Steroid of 21-hydroxylase (P450c21)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3qz1a_	All alpha proteins	Cytochrome P450	Cytochrome P450	automated matches	automated matches	bovine,cow,domestic cattle,domestic cow (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d3qz1b_	All alpha proteins	Cytochrome P450	Cytochrome P450	automated matches	automated matches	bovine,cow,domestic cattle,domestic cow (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d3qz1c_	All alpha proteins	Cytochrome P450	Cytochrome P450	automated matches	automated matches	bovine,cow,domestic cattle,domestic cow (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d3qz1d_	All alpha proteins	Cytochrome P450	Cytochrome P450	automated matches	automated matches	bovine,cow,domestic cattle,domestic cow (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Cytochrome P450	8068660	4001206	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cytochrome P450	8068661	3001061	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cytochrome P450	8068661	3001061	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cytochrome P450	8068661	3001061	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytochrome P450	8068661	3001061	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	p450	e3qz1A1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
B	p450	e3qz1B1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
C	p450	e3qz1C1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
D	p450	e3qz1D1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)
B	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)
C	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)
D	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Steroid 21-hydroxylase	binding organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen steroid 21-monooxygenase activity catalytic activity steroid hydroxylase activity progesterone 21-hydroxylase activity cation binding transition metal ion binding iron ion binding binding organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen steroid 21-monooxygenase activity catalytic activity steroid hydroxylase activity progesterone 21-hydroxylase activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding 17-hydroxyprogesterone 21-hydroxylase activity steroid binding lipid binding	steroid metabolic process primary metabolic process metabolic process cellular process lipid metabolic process lipid biosynthetic process glucocorticoid metabolic process glucocorticoid biosynthetic process biosynthetic process steroid biosynthetic process steroid hormone biosynthetic process	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002401	Cytochrome P450, E-class, group I	Family
A, B, C, D	IPR017972	Cytochrome P450, conserved site	Conserved Site
A, B, C, D	IPR001128	Cytochrome P450	Family
A, B, C, D	IPR036396	Cytochrome P450 superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM				Cytochrome P450

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.