4GWI | pdb_00004gwi

His 62 mutant of the lectin binding domain of lectinolysin complexed with Lewis y

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4gwia_	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	automated matches	automated matches	(Streptococcus mitis ) [TaxId: 28037 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	galactose-binding domain-like	8086774	3000087	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F5_F8_type_C_1	e4gwiA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: F5_F8_type_C_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF22633	NedA-like, galactose-binding domain (F5_F8_type_C_2)	NedA-like, galactose-binding domain	This galactose-binding domain is found in Sialidase from Micromonospora viridifaciens (NedA), which releases sialic acids for use as carbon and energy sources. This domain shows a jelly-roll topology [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Platelet aggregation factor Sm-hPAF	sterol binding binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding fucose binding monosaccharide binding carbohydrate binding toxin activity cation binding ion binding metal ion binding	biological process involved in interspecies interaction between organisms cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing regulation of defense response regulation of cellular defense response regulation of biological process response to stimulus defense response regulation of response to stimulus response to stress regulation of response to stress biological process involved in interspecies interaction between organisms cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing regulation of defense response regulation of cellular defense response regulation of biological process response to stimulus defense response regulation of response to stimulus response to stress regulation of response to stress biological regulation cellular defense response regulation of humoral immune response regulation of immune effector process humoral immune response regulation of response to biotic stimulus regulation of response to external stimulus positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus complement activation positive regulation of immune response innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process regulation of complement activation, lectin pathway complement activation, lectin pathway immune response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus immune effector process immune system process defense response to other organism regulation of immune response regulation of complement activation activation of immune response	cellular anatomical structure membrane extracellular region host cell plasma membrane host cellular component host cell part host cell membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006585	Fucolectin tachylectin-4 pentraxin-1	Domain
A	IPR038700	Thiol-activated cytolysin, C-terminal domain superfamily	Homologous Superfamily
A	IPR036359	Thiol-activated cytolysin superfamily	Homologous Superfamily
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A	IPR000421	Coagulation factor 5/8, C-terminal domain	Domain
A	IPR051941	Blood Group Antigen-Binding Lectin	Family
A	IPR035390	Thiol-activated cytolysin C-terminal	Domain
A	IPR001869	Thiol-activated cytolysin	Family
A	IPR036363	Thiol-activated cytolysin, alpha-beta domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.