4HJ1

Crystal structure of glycoprotein C from Rift Valley Fever Virus (glycosylated)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Phlebovirus_G2_2nd	e4hj1A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Phlebovirus_G2_2nd	ECOD (1.6)
A	Phlebovirus_G2_1st	e4hj1A1	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Phlebovirus_G2_1st	ECOD (1.6)
C	Phlebovirus_G2_2nd	e4hj1C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Phlebovirus_G2_2nd	ECOD (1.6)
C	Phlebovirus_G2_1st	e4hj1C2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Phlebovirus_G2_1st	ECOD (1.6)
D	Phlebovirus_G2_2nd	e4hj1D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Phlebovirus_G2_2nd	ECOD (1.6)
D	Phlebovirus_G2_1st	e4hj1D2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Phlebovirus_G2_1st	ECOD (1.6)
B	Phlebovirus_G2_2nd	e4hj1B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Phlebovirus_G2_2nd	ECOD (1.6)
B	Phlebovirus_G2_1st	e4hj1B1	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Phlebovirus_G2_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.98.50	Mainly Beta	Sandwich	Tick-borne Encephalitis virus Glycoprotein	domain 1	CATH (4.3.0)
A	2.60.40.3770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	2.60.98.50	Mainly Beta	Sandwich	Tick-borne Encephalitis virus Glycoprotein	domain 1	CATH (4.3.0)
C	2.60.40.3770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D	2.60.98.50	Mainly Beta	Sandwich	Tick-borne Encephalitis virus Glycoprotein	domain 1	CATH (4.3.0)
D	2.60.40.3770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	2.60.98.50	Mainly Beta	Sandwich	Tick-borne Encephalitis virus Glycoprotein	domain 1	CATH (4.3.0)
B	2.60.40.3770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07245	Phlebovirus glycoprotein G2 fusion domain (Phlebovirus_G2)	Phlebovirus glycoprotein G2 fusion domain	-	Family
A, B, C, D	PF19019	Phlebovirus glycoprotein G2 C-terminal domain (Phlebo_G2_C)	Phlebovirus glycoprotein G2 C-terminal domain	This family consists of several Phlebovirus glycoprotein G2 C-terminal Ig-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ENVELOPE GLYCOPROTEIN	-	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell adhesion of symbiont to host	cellular anatomical structure membrane virion component virion membrane host cellular component host intracellular membrane-bounded organelle host intracellular part host cell membrane host cell mitochondrion host cell cytoplasm part host intracellular organelle host organelle outer membrane host cell cytoplasm host cell part cellular anatomical structure membrane virion component virion membrane host cellular component host intracellular membrane-bounded organelle host intracellular part host cell membrane host cell mitochondrion host cell cytoplasm part host intracellular organelle host organelle outer membrane host cell cytoplasm host cell part host cell mitochondrial envelope host intracellular region host cell mitochondrial outer membrane host cell mitochondrial membrane host outer membrane host cell endoplasmic reticulum host cell endomembrane system host cell endoplasmic reticulum membrane host cell Golgi membrane host cell Golgi apparatus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR009879	Phlebovirus nonstructural NS-M	Domain
A, B, C, D	IPR009878	Phlebovirus glycoprotein G2, fusion domain	Domain
A, B, C, D	IPR010826	Phlebovirus glycoprotein G1	Domain
A, B, C, D	IPR016404	M polyprotein precursor, phlebovirus	Family
A, B, C, D	IPR043603	Phlebovirus glycoprotein G2, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.