4HKA | pdb_00004hka

Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Bacterial tryptophan 2, 3-dioxygenase-like	8087368	4001603	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	indolic compounds 2, 3-dioxygenase-like	8087369	3001961	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trp_dioxygenase	e4hkaA1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.480	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.10.287.3810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03301	Tryptophan 2,3-dioxygenase (Trp_dioxygenase)	Tryptophan 2,3-dioxygenase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tryptophan 2,3-dioxygenase	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen tryptophan 2,3-dioxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis catabolic process oxoacid metabolic process ketone metabolic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis catabolic process oxoacid metabolic process ketone metabolic process aromatic amino acid family catabolic process indole-containing compound metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process alpha-amino acid metabolic process non-proteinogenic amino acid metabolic process L-tryptophan metabolic process carboxylic acid catabolic process indolalkylamine metabolic process small molecule metabolic process amino acid catabolic process L-tryptophan catabolic process to kynurenine erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process benzene-containing compound metabolic process carboxylic acid metabolic process L-amino acid catabolic process primary metabolic process L-tryptophan catabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process amine metabolic process kynurenine metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process indole-containing compound catabolic process metabolic process small molecule catabolic process biogenic amine metabolic process acetyl-CoA metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process amide catabolic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process purine-containing compound metabolic process L-tryptophan catabolic process to acetyl-CoA organophosphate metabolic process pigmentation eye pigmentation developmental pigmentation compound eye pigmentation pigment metabolic process ocellus pigment metabolic process pigment biosynthetic process ocellus pigment biosynthetic process secondary metabolic process pigment metabolic process involved in pigmentation eye pigment metabolic process secondary metabolite biosynthetic process biosynthetic process ocellus pigmentation ommochrome metabolic process pigment metabolic process involved in developmental pigmentation eye pigment biosynthetic process ommochrome biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004981	Tryptophan 2,3-dioxygenase	Family
A	IPR037217	Tryptophan/Indoleamine 2,3-dioxygenase-like	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.