4NKY

Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate 17alpha-hydroxyprogesterone

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cytochrome P450	8068657	3001061	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cytochrome P450	8068657	3001061	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cytochrome P450	8068657	3001061	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytochrome P450	8068657	3001061	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	p450	e4nkyA1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
B	p450	e4nkyB1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
C	p450	e4nkyC1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
D	p450	e4nkyD1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)
B	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)
C	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)
D	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Steroid 17-alpha-hydroxylase/17,20 lyase	oxygen binding binding small molecule binding oxidoreductase activity monooxygenase activity steroid 17-alpha-monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity steroid hydroxylase activity organic cyclic compound binding tetrapyrrole binding heme binding cation binding transition metal ion binding oxygen binding binding small molecule binding oxidoreductase activity monooxygenase activity steroid 17-alpha-monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity steroid hydroxylase activity organic cyclic compound binding tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding lyase activity	steroid metabolic process primary metabolic process metabolic process cellular process lipid metabolic process ketone metabolic process regulation of hormone levels biological regulation C21-steroid hormone metabolic process hormone metabolic process progesterone metabolic process olefinic compound metabolic process regulation of biological quality lipid biosynthetic process steroid metabolic process primary metabolic process metabolic process cellular process lipid metabolic process ketone metabolic process regulation of hormone levels biological regulation C21-steroid hormone metabolic process hormone metabolic process progesterone metabolic process olefinic compound metabolic process regulation of biological quality lipid biosynthetic process glucocorticoid metabolic process glucocorticoid biosynthetic process biosynthetic process steroid biosynthetic process steroid hormone biosynthetic process hormone biosynthetic process developmental process reproductive process sex differentiation developmental process involved in reproduction androgen metabolic process androgen biosynthetic process	somatodendritic compartment cell body cellular anatomical structure neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm somatodendritic compartment cell body cellular anatomical structure neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002401	Cytochrome P450, E-class, group I	Family
A, B, C, D	IPR017972	Cytochrome P450, conserved site	Conserved Site
A, B, C, D	IPR001128	Cytochrome P450	Family
A, B, C, D	IPR036396	Cytochrome P450 superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P05093	congenital adrenal hyperplasia prostate cancer hypogonadism hypopituitarism non-alcoholic fatty liver disease Hyperkalemia male infertility Sheehan syndrome neuralgia amenorrhea breast carcinoma congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency female infertility hypoactive sexual desire disorder malignant hypertension congenital adrenal hyperplasia prostate cancer hypogonadism hypopituitarism non-alcoholic fatty liver disease Hyperkalemia male infertility Sheehan syndrome neuralgia amenorrhea breast carcinoma congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency female infertility hypoactive sexual desire disorder malignant hypertension hepatocellular carcinoma oral candidiasis polycystic ovary syndrome autism spectrum disorder breast cancer chromomycosis tinea corporis dermatophytosis of groin and perianal area endogenous depression histoplasmosis hypertensive disorder pancreatic ductal adenocarcinoma 46,XY disorder of sex development due to isolated 17,20-lyase deficiency bipolar disorder seborrheic dermatitis coccidioidomycosis myocardial infarction tinea pedis heart disease hyperandrogenism ovarian cyst paracoccidioidomycosis hypogonadotropic hypogonadism pityriasis versicolor adrenal gland hyperfunction potassium deficiency disease attention deficit hyperactivity disorder, inattentive type blastomycosis colorectal cancer corpus luteum cyst X-linked adrenal hypoplasia congenita

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.