4Q26

Crystal Structure of Galectin-1 in Complex with N-Acetyllactosamine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4q26a_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Galectin (animal S-lectin)	Galectin-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth G]	d4q26g_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Galectin (animal S-lectin)	Galectin-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth H]	d4q26h_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Galectin (animal S-lectin)	Galectin-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4q26b_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Galectin (animal S-lectin)	Galectin-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8035768	3000120	SCOP2B (2022-06-29)
C [auth G]	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8035768	3000120	SCOP2B (2022-06-29)
D [auth H]	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8035768	3000120	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8035768	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Gal-bind_lectin	e4q26A1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)
C [auth G]	Gal-bind_lectin	e4q26G1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)
D [auth H]	Gal-bind_lectin	e4q26H1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)
B	Gal-bind_lectin	e4q26B1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C [auth G]	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
D [auth H]	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth G], D [auth H]	PF00337	Galactoside-binding lectin (Gal-bind_lectin)	Galactoside-binding lectin	This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth G], D [auth H]	Galectin-1	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity oligosaccharide binding lactose binding disaccharide binding carbohydrate binding RNA binding organic cyclic compound binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity oligosaccharide binding lactose binding disaccharide binding carbohydrate binding RNA binding organic cyclic compound binding nucleic acid binding extracellular matrix binding laminin binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction cellular process positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development myoblast differentiation multicellular organismal process cell development mononuclear cell differentiation mature B cell differentiation B cell activation involved in immune response lymphocyte activation cell activation involved in immune response lymphocyte differentiation leukocyte activation B cell differentiation leukocyte activation involved in immune response lymphocyte activation involved in immune response mature B cell differentiation involved in immune response immune response hemopoiesis B cell activation cell activation immune effector process immune system process plasma cell differentiation leukocyte differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation alpha-beta T cell differentiation involved in immune response regulation of cell development negative regulation of cell adhesion negative regulation of cell fate commitment multicellular organism development negative regulation of T cell differentiation T cell activation regulation of T-helper cell differentiation alpha-beta T cell activation regulation of immune system process T-helper cell differentiation alpha-beta T cell lineage commitment negative regulation of leukocyte differentiation negative regulation of immune effector process negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of T-helper 17 cell lineage commitment negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process T-helper 17 cell differentiation cell fate commitment CD4-positive or CD8-positive, alpha-beta T cell lineage commitment regulation of developmental process negative regulation of T-helper 17 cell differentiation CD4-positive, alpha-beta T cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response regulation of cell-cell adhesion negative regulation of cell differentiation regulation of T-helper 17 cell differentiation negative regulation of developmental process regulation of cell adhesion negative regulation of T-helper 17 type immune response negative regulation of cell development regulation of CD4-positive, alpha-beta T cell activation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation regulation of immune effector process regulation of leukocyte differentiation negative regulation of biological process regulation of cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response T cell differentiation CD4-positive, alpha-beta T cell lineage commitment negative regulation of hemopoiesis regulation of adaptive immune response negative regulation of immune response T-helper cell lineage commitment negative regulation of adaptive immune response T-helper 17 cell lineage commitment negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of lymphocyte differentiation regulation of immune response negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of leukocyte activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation negative regulation of lymphocyte activation leukocyte cell-cell adhesion cell adhesion regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains cell-cell adhesion alpha-beta T cell activation involved in immune response CD4-positive, alpha-beta T cell activation negative regulation of cellular process regulation of multicellular organismal process regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of T-helper 17 cell lineage commitment regulation of T-helper 17 type immune response negative regulation of response to stimulus regulation of cell fate commitment regulation of T cell activation T cell differentiation involved in immune response T cell lineage commitment adaptive immune response negative regulation of T-helper cell differentiation negative regulation of cell activation negative regulation of immune system process positive T cell selection regulation of hemopoiesis T cell selection T-helper 17 type immune response apoptotic process cell death programmed cell death positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation positive regulation of leukocyte activation positive regulation of immune system process positive regulation of T cell activation positive regulation of cell adhesion lymphocyte costimulation positive regulation of multicellular organismal process T cell costimulation biological process involved in interspecies interaction between organisms positive regulation of viral life cycle positive regulation of viral process viral life cycle modulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of viral entry into host cell regulation of viral life cycle regulation of viral process symbiont entry into host cell viral process symbiont entry into host positive regulation of viral entry into host cell positive regulation by symbiont of entry into host regulation of biological process involved in symbiotic interaction	protein complex involved in cell-cell adhesion protein-containing complex galectin complex protein complex involved in cell adhesion extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein complex involved in cell-cell adhesion protein-containing complex galectin complex protein complex involved in cell adhesion extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol plasma membrane membrane membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth G], D [auth H]	IPR044156	Galectin-like	Family
A, B, C [auth G], D [auth H]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C [auth G], D [auth H]	IPR001079	Galectin, carbohydrate recognition domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C [auth G], D [auth H]	Pharos: P09382	cirrhosis of liver keloid nephritis non-small cell lung carcinoma Liver Cirrhosis, Experimental osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Sjogren syndrome X-linked mixed deafness with perilymphatic gusher acute myeloid leukemia lung carcinoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma cirrhosis of liver keloid nephritis non-small cell lung carcinoma Liver Cirrhosis, Experimental osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Sjogren syndrome X-linked mixed deafness with perilymphatic gusher acute myeloid leukemia lung carcinoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma breast cancer cystic fibrosis gastric carcinoma large cell medulloblastoma lymphoplasmacytic lymphoma medulloblastoma pancreatic ductal adenocarcinoma pituitary cancer ulcerative colitis breast fibroadenoma diabetes mellitus glioblastoma malignant ependymoma nasopharyngeal carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.