4UHX

Human aldehyde oxidase in complex with phthalazine and thioridazine

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Structure Motif: Primary M-CSA Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fer2_2	e4uhxA1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
A	Fer2	e4uhxA4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
A	Ald_Xan_dh_C2	e4uhxA3	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
A	CO_deh_flav_C	e4uhxA5	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
A	FAD_binding_5	e4uhxA2	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
A	Ald_Xan_dh_C	e4uhxA6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (utative)
A	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (utative)
A	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (utative)
A	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (utative)
A	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (utative)
A	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00941	FAD binding domain in molybdopterin dehydrogenase (FAD_binding_5)	FAD binding domain in molybdopterin dehydrogenase	-	Family
A	PF01799	[2Fe-2S] binding domain (Fer2_2)	[2Fe-2S] binding domain	-	Domain
A	PF01315	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain (Ald_Xan_dh_C)	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	Domain
A	PF20256	Molybdopterin cofactor-binding domain (MoCoBD_2)	Molybdopterin cofactor-binding domain	-	Domain
A	PF03450	CO dehydrogenase flavoprotein C-terminal domain (CO_deh_flav_C)	CO dehydrogenase flavoprotein C-terminal domain	-	Domain
A	PF02738	Molybdopterin cofactor-binding domain (MoCoBD_1)	Molybdopterin cofactor-binding domain	-	Domain
A	PF00111	2Fe-2S iron-sulfur cluster binding domain (Fer2)	2Fe-2S iron-sulfur cluster binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ALDEHYDE OXIDASE	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity aldehyde oxidase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity aldehyde oxidase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor identical protein binding protein binding protein homodimerization activity protein dimerization activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding cation binding transition metal ion binding iron ion binding metal ion binding molybdopterin cofactor binding NAD binding purine nucleotide binding adenyl nucleotide binding	primary metabolic process metabolic process cellular process lipid metabolic process cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus xenobiotic metabolic process response to xenobiotic stimulus	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
A	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
A	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
A	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
A	IPR002888	[2Fe-2S]-binding	Domain
A	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
A	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
A	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
A	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
A	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
A	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
A	IPR022407	Oxidoreductase, molybdopterin binding site	Binding Site
A	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
A	IPR014313	Aldehyde oxidase	Family
A	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
A	IPR016166	FAD-binding domain, PCMH-type	Domain
A	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
A	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
A	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
A	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
A	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q06278	prostate cancer pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adenoma atypical teratoid rhabdoid tumor Gaucher disease invasive ductal breast carcinoma lung carcinoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Prostatic Neoplasms adrenal cortex carcinoma breast carcinoma prostate cancer pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adenoma atypical teratoid rhabdoid tumor Gaucher disease invasive ductal breast carcinoma lung carcinoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Prostatic Neoplasms adrenal cortex carcinoma breast carcinoma glioblastoma lung adenocarcinoma malignant colon neoplasm malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer atopic eczema cystic fibrosis hereditary xanthinuria lung cancer malignant ependymoma malignant pancreatic neoplasm

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	aldehyde oxidase M-CSA #968	Aldehyde oxidase is a member of the xanthine oxidase family. It is a complex molybdoenzyme containing a Mo cofactor (Moco), flavin adenine nucleotide (FAD) and two Fe₂S₂ clusters. The enzyme has broad substrate specificity and catalyses a wide range of reactions. This includes the oxidation of aldehydes and several N-heterocycles, as well as the reduction of some substrates. In the human liver, the enzyme plays an essential role in the detoxification of xenobiotics and contributes to the hepatic clearance of many other drugs.	Defined by 2 residues: LYS:A-893GLU:A-1270 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.2.3.1 (PDB Primary Data) Search M-CSA Motif + EC 1.2.3.1 EC: 1.17.3 (UniProt) Search M-CSA Motif + EC 1.17.3