Annotations: 5HAF

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PRK14848	e5hafA1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PRK14848	ECOD (1.6)
B	PRK14848	e5hafB1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PRK14848	ECOD (1.6)

Chains	Accession	Name	Description	Comments	Source
A, B	PF22102	ElaD/SseL-like C-terminal (ElaD-SseL-like_C)	ElaD/SseL-like C-terminal	This entry represents the C-terminal catalytic domain from a group of CE proteases from human pathogens including ElaD from E.coli, SseL from Salmonella typhimurium and ShiCE from Shigella [1,2], which are dedicated deubiquitinases (DUBs), proteases ...	This entry represents the C-terminal catalytic domain from a group of CE proteases from human pathogens including ElaD from E.coli, SseL from Salmonella typhimurium and ShiCE from Shigella [1,2], which are dedicated deubiquitinases (DUBs), proteases that reverse the addition of ubiquitin to substrates, and effectively hijacks the host's ubiquitination processes [2].	Domain
A, B	PF22103	ElaD/SseL N-terminal domain (ElaD_SseL-like_N)	ElaD/SseL N-terminal domain	-	Repeat

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Deubiquitinase SseL	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure extracellular region host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region