6CAJ

Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth H]	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8101599	3000693	SCOP2B (2022-06-29)
H [auth G]	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8101599	3000693	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Hexapep_2_1	e6cajB2	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: Hexapep_2_1	ECOD (1.6)
A [auth B]	NTP_transferase	e6cajB1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase	ECOD (1.6)
F [auth A]	Hexapep_2_1	e6cajA2	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: Hexapep_2_1	ECOD (1.6)
F [auth A]	NTP_transferase	e6cajA1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase	ECOD (1.6)
B [auth J]	NTP_transferase	e6cajJ1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase	ECOD (1.6)
G [auth I]	NTP_transferase	e6cajI1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase	ECOD (1.6)
C [auth H]	IF-2B_N_1	e6cajH2	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: IF-2B_N_1	ECOD (1.6)
C [auth H]	IF-2B_C	e6cajH1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: IF-2B_C	ECOD (1.6)
H [auth G]	IF-2B_N_1	e6cajG1	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: IF-2B_N_1	ECOD (1.6)
H [auth G]	IF-2B_C	e6cajG2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: IF-2B_C	ECOD (1.6)
I [auth D]	KOG1465	e6cajD1	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: KOG1465	ECOD (1.6)
I [auth D]	IF-2B_C	e6cajD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: IF-2B_C	ECOD (1.6)
D [auth C]	KOG1465	e6cajC1	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: KOG1465	ECOD (1.6)
D [auth C]	IF-2B_C	e6cajC2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: IF-2B_C	ECOD (1.6)
E [auth F]	IF-2B_N_1	e6cajF2	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: IF-2B_N_1	ECOD (1.6)
E [auth F]	IF-2B_C	e6cajF1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: IF-2B_C	ECOD (1.6)
J [auth E]	IF-2B_N_1	e6cajE1	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: IF-2B_N_1	ECOD (1.6)
J [auth E]	IF-2B_C	e6cajE2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: IF-2B_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth J], G [auth I]	PF00483	Nucleotidyl transferase (NTP_transferase)	Nucleotidyl transferase	-	Family
C [auth H], H [auth G]	PF01008	Initiation factor 2 subunit family (IF-2B)	Initiation factor 2 subunit family	-	Family
D [auth C], I [auth D]	PF01008	Initiation factor 2 subunit family (IF-2B)	Initiation factor 2 subunit family	-	Family
E [auth F], J [auth E]	PF01008	Initiation factor 2 subunit family (IF-2B)	Initiation factor 2 subunit family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], F [auth A]	Translation initiation factor eIF-2B subunit epsilon	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process head development forebrain development biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process head development forebrain development animal organ development brain development nervous system development pallium development multicellular organism development central nervous system development anatomical structure development telencephalon development hippocampus development limbic system development system development response to stimulus response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process cytoplasmic translation cytoplasmic translational initiation response to hexose response to monosaccharide response to carbohydrate response to glucose cellular developmental process astrocyte differentiation cell development glial cell development neurogenesis astrocyte development gliogenesis glial cell differentiation cell differentiation oligodendrocyte development oligodendrocyte differentiation gonad development reproductive system development reproductive process female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development ovarian follicle development myelination axon ensheathment ensheathment of neurons positive regulation of protein metabolic process positive regulation of translation positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of translational initiation regulation of protein metabolic process regulation of macromolecule metabolic process regulation of gene expression positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process positive regulation of translational initiation regulation of metabolic process response to stress response to heat response to abiotic stimulus response to temperature stimulus cellular response to stress response to endoplasmic reticulum stress	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex eukaryotic translation initiation factor 2B complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B [auth J], G [auth I]	Translation initiation factor eIF-2B subunit gamma	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process oligodendrocyte development cellular developmental process biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process oligodendrocyte development cellular developmental process cell development nervous system development glial cell development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development system development response to stimulus response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response cytoplasmic translation cytoplasmic translational initiation response to stress response to heat response to abiotic stimulus response to temperature stimulus response to hexose response to monosaccharide response to carbohydrate response to glucose	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex eukaryotic translation initiation factor 2B complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex
C [auth H], H [auth G]	Translation initiation factor eIF-2B subunit alpha	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity identical protein binding protein binding	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process oligodendrocyte development cellular developmental process biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process oligodendrocyte development cellular developmental process cell development nervous system development glial cell development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development system development response to stimulus response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response cytoplasmic translation cytoplasmic translational initiation response to stress response to heat response to abiotic stimulus response to temperature stimulus response to hexose response to monosaccharide response to carbohydrate response to glucose	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol protein-containing complex eukaryotic translation initiation factor 2B complex cell periphery plasma membrane
D [auth C], I [auth D]	Translation initiation factor eIF-2B subunit beta	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity guanyl nucleotide binding GTP binding guanyl ribonucleotide binding	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process oligodendrocyte development cellular developmental process biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process oligodendrocyte development cellular developmental process cell development nervous system development glial cell development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development system development gonad development reproductive system development reproductive process female gonad development sex differentiation animal organ development female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development ovarian follicle development response to stimulus response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of biosynthetic process regulation of translational initiation regulation of protein metabolic process regulation of macromolecule metabolic process regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process cytoplasmic translation cytoplasmic translational initiation myelination axon ensheathment ensheathment of neurons response to stress response to heat response to abiotic stimulus response to temperature stimulus response to hexose response to monosaccharide response to carbohydrate response to glucose	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex eukaryotic translation initiation factor 2B complex
E [auth F], J [auth E]	Translation initiation factor eIF-2B subunit delta	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process oligodendrocyte development cellular developmental process biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process multicellular organismal process oligodendrocyte development cellular developmental process cell development nervous system development glial cell development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development system development gonad development reproductive system development reproductive process female gonad development sex differentiation animal organ development female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development ovarian follicle development response to stimulus response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response cytoplasmic translation cytoplasmic translational initiation myelination axon ensheathment ensheathment of neurons regulation of biosynthetic process regulation of protein metabolic process regulation of macromolecule metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process response to stress response to heat response to abiotic stimulus response to temperature stimulus response to hexose response to monosaccharide response to carbohydrate response to glucose	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex eukaryotic translation initiation factor 2B complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], F [auth A]	IPR044123	Translation initiation factor eIF-2B subunit epsilon, W2 domain	Domain
A [auth B], F [auth A]	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth B], F [auth A]	IPR003307	W2 domain	Domain
A [auth B], F [auth A]	IPR035543	Translation initiation factor eIF-2B subunit epsilon, N-terminal	Domain
A [auth B], F [auth A]	IPR011004	Trimeric LpxA-like superfamily	Homologous Superfamily
A [auth B], F [auth A]	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A [auth B], F [auth A]	IPR051956	eIF2B Complex Subunit Epsilon	Family
B [auth J], G [auth I]	IPR051960	Eukaryotic Initiation Factor 2B Subunit Gamma	Family
B [auth J], G [auth I]	IPR005835	Nucleotidyl transferase domain	Domain
B [auth J], G [auth I]	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
C [auth H], H [auth G]	IPR000649	Initiation factor 2B-related	Family
C [auth H], H [auth G]	IPR051501	Eukaryotic initiation factor 2B subunits alpha/beta/delta	Family
C [auth H], H [auth G]	IPR042529	Initiation factor 2B-like, C-terminal	Homologous Superfamily
C [auth H], H [auth G]	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily
C [auth H], H [auth G]	IPR042528	Translation initiation factor eIF-2B subunit alpha, N-terminal	Homologous Superfamily
D [auth C], I [auth D]	IPR051855	Eukaryotic initiation factor 2B subunit beta	Family
D [auth C], I [auth D]	IPR000649	Initiation factor 2B-related	Family
D [auth C], I [auth D]	IPR042529	Initiation factor 2B-like, C-terminal	Homologous Superfamily
D [auth C], I [auth D]	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily
E [auth F], J [auth E]	IPR000649	Initiation factor 2B-related	Family
E [auth F], J [auth E]	IPR042529	Initiation factor 2B-like, C-terminal	Homologous Superfamily
E [auth F], J [auth E]	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], F [auth A]	Pharos: Q13144	leukodystrophy leukoencephalopathy with vanishing white matter Adenocarcinoma of Lung esophageal adenocarcinoma lung adenocarcinoma ovarian cancer malignant mesothelioma ovarioleukodystrophy osteosarcoma
B [auth J], G [auth I]	Pharos: Q9NR50	leukoencephalopathy with vanishing white matter leukodystrophy Ataxias, Hereditary ovarioleukodystrophy
C [auth H], H [auth G]	Pharos: Q14232	leukoencephalopathy with vanishing white matter leukodystrophy Adenocarcinoma of Lung ovarian cancer glioblastoma lung adenocarcinoma ovarioleukodystrophy lung cancer
D [auth C], I [auth D]	Pharos: P49770	leukoencephalopathy with vanishing white matter leukodystrophy Ataxias, Hereditary heart disease ovarioleukodystrophy
E [auth F], J [auth E]	Pharos: Q9UI10	leukoencephalopathy with vanishing white matter leukodystrophy Adenocarcinoma of Lung lung adenocarcinoma ovarian cancer lung cancer ovarioleukodystrophy Crohn disease osteosarcoma