6DZL

Ebola virus Makona variant GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab

External Resource: Annotation

Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Filo_glycop	e6dzlA1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
E [auth B]	Filo_glycop	e6dzlB1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
I [auth C]	Filo_glycop	e6dzlC1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
B [auth D]	Ebola-like_HR1-HR2	e6dzlD1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
F [auth E]	Ebola-like_HR1-HR2	e6dzlE1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
J [auth F]	Ebola-like_HR1-HR2	e6dzlF1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
C [auth J]	V-set	e6dzlJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
G [auth K]	V-set	e6dzlK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
K [auth L]	V-set	e6dzlL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
D [auth G]	V-set_8	e6dzlG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
H	V-set_8	e6dzlH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
L [auth I]	V-set_8	e6dzlI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
C [auth J], G [auth K], K [auth L]	Fab ADI-15878	V-KAPPA	Homo sapiens (human)	IGKV1-501, IGKJ401, IGKJ4*02	V-DOMAIN V-KAPPA	IG	VH-V-KAPPA	IMGT (202500-0)
D [auth G], H, L [auth I]	Fab ADI-15878	VH	Homo sapiens (human)	IGHV3-2304, IGHJ401, IGHJ402, IGHJ403	V-DOMAIN VH	IG	VH-V-KAPPA	IMGT (202500-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C [auth J], G [auth K], K [auth L]	Light Chain	IGKV1	Kappa	ebola virus makona gp2 \| ebola virus makona gp1, ebola virus makona gp2 \| ebola virus makona gp1 \| ebola virus makona gp2	SAbDab (2025-01-10)
D [auth G], H, L [auth I]	Heavy Chain	IGHV3	-	ebola virus makona gp2 \| ebola virus makona gp1, ebola virus makona gp2 \| ebola virus makona gp1 \| ebola virus makona gp2	SAbDab (2025-01-10)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth B], I [auth C]	PF01611	Filovirus glycoprotein (Filo_glycop)	Filovirus glycoprotein	-	Family
B [auth D], F [auth E], J [auth F]	PF22307	Envelope glycoprotein GP2-like, HR1-HR2 (Ebola-like_HR1-HR2)	Envelope glycoprotein GP2-like, HR1-HR2	This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [1-5]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel ...	This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [1-5]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel orientation). This domain may have been acquired via horizontal transfer from retroviruses.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth B], I [auth C]	Ebola virus Makona GP1	binding lipid binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity biological process involved in interspecies interaction between organisms modulation by virus of host process virus-mediated perturbation of host defense response biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host process modulation of process of another organism modulation by virus of host cellular process symbiont entry into host cell viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity biological process involved in interspecies interaction between organisms modulation by virus of host process virus-mediated perturbation of host defense response biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host process modulation of process of another organism modulation by virus of host cellular process symbiont entry into host cell symbiont entry into host viral life cycle import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization clathrin-dependent endocytosis cellular process clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus response to host defenses response to stimulus response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host defenses response to defenses of other organism response to external stimulus response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell adhesion of symbiont to host	cellular anatomical structure membrane virion component virion membrane extracellular region viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane
B [auth D], F [auth E], J [auth F]	Ebola virus Makona GP2	binding lipid binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity biological process involved in interspecies interaction between organisms modulation by virus of host process virus-mediated perturbation of host defense response biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host process modulation of process of another organism modulation by virus of host cellular process symbiont entry into host cell viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity biological process involved in interspecies interaction between organisms modulation by virus of host process virus-mediated perturbation of host defense response biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host process modulation of process of another organism modulation by virus of host cellular process symbiont entry into host cell symbiont entry into host viral life cycle import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization clathrin-dependent endocytosis cellular process clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus response to host defenses response to stimulus response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host defenses response to defenses of other organism response to external stimulus response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell adhesion of symbiont to host	cellular anatomical structure membrane virion component virion membrane extracellular region viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane
C [auth J], G [auth K], K [auth L]	Fv domain of ADI-15878 Fab light chain	-	-	-
D [auth G], H, L [auth I]	Fv domain of ADI-15878 Fab heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth B], I [auth C]	IPR014625	Filoviruses glycoprotein	Family
A, E [auth B], I [auth C]	IPR002561	Filoviruses glycoprotein, extracellular domain	Domain
A, E [auth B], I [auth C]	IPR054584	Envelope glycoprotein GP2-like, HR1-HR2	Domain
B [auth D], F [auth E], J [auth F]	IPR014625	Filoviruses glycoprotein	Family
B [auth D], F [auth E], J [auth F]	IPR002561	Filoviruses glycoprotein, extracellular domain	Domain
B [auth D], F [auth E], J [auth F]	IPR054584	Envelope glycoprotein GP2-like, HR1-HR2	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.