6E67

Structure of beta2 adrenergic receptor fused to a Gs peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lysozyme-like	8093428	3001879	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091150	3000473	SCOP2B (2022-06-29)
B	SCOP2 Family	Phage lysozyme	8093427	4000895	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Lysozyme-like	8093428	3001879	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	G protein-coupled receptor-like	8091150	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_3	e6e67A1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
A	Phage_lysozyme_2	e6e67A2	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	7tm_1_3	e6e67B1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
B	Phage_lysozyme_2	e6e67B2	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A, B	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GC ...	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera	amide binding amyloid-beta binding binding peptide binding protein binding enzyme binding adenylate cyclase binding G protein-coupled amine receptor activity molecular transducer activity beta2-adrenergic receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity amide binding amyloid-beta binding binding peptide binding protein binding enzyme binding adenylate cyclase binding G protein-coupled amine receptor activity molecular transducer activity beta2-adrenergic receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity adrenergic receptor activity protein-containing complex binding potassium channel regulator activity channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity identical protein binding protein homodimerization activity protein dimerization activity cation binding ion binding catecholamine binding norepinephrine binding small molecule binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding D1 dopamine receptor binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding G-protein beta/gamma-subunit complex binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity enzyme regulator activity cyclase regulator activity enzyme activator activity cyclase activator activity molecular function activator activity adenylate cyclase regulator activity adenylate cyclase activator activity metal ion binding hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity	multicellular organismal process response to nutrient levels response to stimulus homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis response to dietary excess diet induced thermogenesis metabolic process cellular process energy homeostasis response to stress response to abiotic stimulus response to cold multicellular organismal process response to nutrient levels response to stimulus homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis response to dietary excess diet induced thermogenesis metabolic process cellular process energy homeostasis response to stress response to abiotic stimulus response to cold response to temperature stimulus regulation of developmental process positive regulation of biological process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development regulation of multicellular organismal process developmental process regulation of multicellular organismal development regulation of biological process bone mineralization animal organ development biological regulation tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification regulation of multicellular organism growth regulation of growth regulation of developmental growth negative regulation of multicellular organism growth developmental growth negative regulation of developmental process growth negative regulation of biological process multicellular organism growth negative regulation of developmental growth negative regulation of growth negative regulation of multicellular organismal process cellular response to stimulus adenylate cyclase-activating adrenergic receptor signaling pathway regulation of cellular process signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation system process regulation of system process muscle contraction muscle system process regulation of muscle system process negative regulation of muscle contraction smooth muscle contraction regulation of smooth muscle contraction regulation of muscle contraction negative regulation of smooth muscle contraction positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process cell surface receptor protein tyrosine kinase signaling pathway cellular component biogenesis cellular component assembly regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation activation of transmembrane receptor protein tyrosine kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process cellular component organization positive regulation of molecular function positive regulation of protein modification process protein-containing complex assembly cellular component organization or biogenesis protein metabolic process positive regulation of protein kinase activity enzyme-linked receptor protein signaling pathway positive regulation of transferase activity cell surface receptor signaling pathway protein-containing complex organization positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation localization import into cell transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport cellular localization endosome to lysosome transport intracellular transport lysosomal transport establishment of localization in cell vacuolar transport positive regulation of organelle organization catabolic process regulation of cellular component organization positive regulation of cellular component organization regulation of autophagosome maturation macroautophagy autophagy protein-containing complex disassembly regulation of autophagy regulation of protein-containing complex disassembly autophagosome maturation positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of protein-containing complex disassembly cellular component disassembly positive regulation of autophagy regulation of catabolic process positive regulation of autophagosome maturation regulation of organelle organization positive regulation of catabolic process organelle organization regulation of macroautophagy lipophagy positive regulation of lipophagy regulation of lipophagy response to psychosocial stress regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication positive regulation of signaling ligand-gated ion channel signaling pathway ionotropic glutamate receptor signaling pathway glutamate receptor signaling pathway AMPA selective glutamate receptor signaling pathway regulation of tube diameter regulation of systemic arterial blood pressure mediated by a chemical signal regulation of blood pressure regulation of tube size norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure negative regulation of blood pressure regulation of systemic arterial blood pressure by norepinephrine-epinephrine regulation of systemic arterial blood pressure circulatory system process negative regulation of systemic arterial blood pressure vascular process in circulatory system regulation of biological quality blood vessel diameter maintenance vasodilation blood circulation regulation of anatomical structure size negative regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication negative regulation of cellular process regulation of G protein-coupled receptor signaling pathway positive regulation of cAMP/PKA signal transduction cAMP/PKA signal transduction regulation of cAMP/PKA signal transduction cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to amyloid-beta regulation of localization regulation of transport regulation of monoatomic ion transport regulation of sodium ion transport metal ion transport monoatomic ion transport regulation of metal ion transport monoatomic cation transport sodium ion transport heat generation regulation of postsynaptic membrane potential modulation of chemical synaptic transmission positive regulation of excitatory postsynaptic potential chemical synaptic transmission, postsynaptic synaptic signaling modulation of excitatory postsynaptic potential mini excitatory postsynaptic potential trans-synaptic signaling nervous system process cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of mini excitatory postsynaptic potential positive regulation of mini excitatory postsynaptic potential regulation of trans-synaptic signaling anterograde trans-synaptic signaling excitatory postsynaptic potential regulation of membrane potential epithelium development ectodermal placode morphogenesis epidermis development molting cycle process hair cycle hair follicle placode formation ectodermal placode formation anatomical structure morphogenesis skin development skin epidermis development hair follicle development molting cycle anatomical structure formation involved in morphogenesis ectodermal placode development hair cycle process sensory perception of chemical stimulus sensory perception sensory perception of smell response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to glucagon cellular response to glucagon stimulus cellular response to endogenous stimulus response to hormone cellular response to hormone stimulus skeletal system development bone development system development regulation of body fluid levels wound healing homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion coagulation response to wounding platelet activation cognition response to ketone response to prostaglandin response to lipid response to alcohol cellular response to prostaglandin stimulus cellular response to prostaglandin E stimulus cellular response to alcohol cellular response to lipid response to prostaglandin E cellular response to ketone protein localization establishment of protein localization nitrogen compound transport cellular macromolecule localization regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion regulation of hormone secretion regulation of protein localization regulation of peptide secretion hormone secretion protein localization to extracellular region peptide secretion regulation of secretion by cell secretion by cell amide transport signal release secretion regulation of peptide transport regulation of establishment of protein localization export from cell regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport insulin secretion regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response inflammatory response to antigenic stimulus regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus defense response immune response negative regulation of immune response regulation of inflammatory response to antigenic stimulus response to external stimulus regulation of inflammatory response negative regulation of immune system process immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response positive regulation of adenylate cyclase activity positive regulation of cyclase activity activation of adenylate cyclase activity regulation of adenylate cyclase activity positive regulation of lyase activity response to dopamine cellular response to dopamine response to monoamine response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus G protein-coupled dopamine receptor signaling pathway cellular response to monoamine stimulus renal system process chemical homeostasis multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis renal water homeostasis biological process involved in interspecies interaction between organisms response to other organism response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus carbohydrate derivative catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process aminoglycan metabolic process peptidoglycan metabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle neuronal dense core vesicle bounding membrane of organelle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle membrane protein-containing complex receptor complex Golgi apparatus endosome membrane endosome cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane lytic vacuole vacuole lysosome early endosome nucleus extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane membrane protein complex heterotrimeric G-protein complex side of membrane cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol Golgi apparatus subcompartment organelle subcompartment trans-Golgi network membrane trans-Golgi network host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000332	Beta 2 adrenoceptor	Family
A, B	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A, B	IPR002233	Adrenoceptor family	Family
A, B	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A, B	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
A, B	IPR011025	G protein alpha subunit, helical insertion	Homologous Superfamily
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR000367	G-protein alpha subunit, group S	Family
A, B	IPR052619	Bacteriophage lysozyme-like	Family
A, B	IPR001165	T4-type lysozyme	Family
A, B	IPR034690	Endolysin T4 type	Family
A, B	IPR002196	Glycoside hydrolase, family 24	Family
A, B	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A, B	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P63092	asthma cardiomyopathy dilated cardiomyopathy Ventricular Dysfunction, Left prostate cancer HIV infectious disease nervous system disorder AIDS dementia complex chronic obstructive pulmonary disease lung disease potassium deficiency disease obesity disorder bipolar disorder ovarian cancer essential tremor asthma cardiomyopathy dilated cardiomyopathy Ventricular Dysfunction, Left prostate cancer HIV infectious disease nervous system disorder AIDS dementia complex chronic obstructive pulmonary disease lung disease potassium deficiency disease obesity disorder bipolar disorder ovarian cancer essential tremor breast fibroadenoma peripheral nervous system disease familial hyperlipidemia lung adenocarcinoma cardiac arrest glaucoma hereditary diffuse gastric adenocarcinoma pulmonary emphysema hypertensive disorder inherited susceptibility to asthma atrial fibrillation ocular hypertension dilated cardiomyopathy 1A breast cancer Parkinson disease vasomotor rhinitis bronchiectasis peripheral neuropathy fibromyalgia viral encephalitis lung cancer gastric cancer malignant colon neoplasm hypertrophic cardiomyopathy allergic rhinitis myocardial ischemia seasonal allergic rhinitis non-small cell lung carcinoma intrinsic asthma atrioventricular block open-angle glaucoma dry eye syndrome B-cell chronic lymphocytic leukemia osteosarcoma breast carcinoma bronchitis gastric neoplasm hemangioma malignant ependymoma medulloblastoma psoriasis hyperlipidemia allergic asthma monogenic obesity rhinitis anaphylaxis common cold coronary artery disease atopic conjunctivitis invasive ductal breast carcinoma autism ductal breast carcinoma in situ McCune-Albright syndrome progressive osseous heteroplasia pseudohypoparathyroidism type 1A pseudohypoparathyroidism polycystic ovary syndrome acromegaly pseudohypoparathyroidism type 1B cholangiocarcinoma pseudopseudohypoparathyroidism precocious puberty obesity disorder substance withdrawal syndrome pseudohypoaldosteronism ACTH-independent macronodular adrenal hyperplasia 1 neuroblastoma brachydactyly intellectual disability pseudohypoparathyroidism type 1C Cafe-au-Lait Spots hypertensive disorder monostotic fibrous dysplasia cancer colorectal cancer intrahepatic cholangiocarcinoma endocrine system disease autosomal dominant pseudohypoaldosteronism type 1 sex cord-stromal tumor Cushing disease due to pituitary adenoma adrenal gland cancer growth hormone-producing pituitary gland adenoma pilocytic astrocytoma tuberculosis congenital hypothyroidism interstitial cystitis Cushing syndrome large cell medulloblastoma progressive supranuclear palsy malignant glioma acquired metabolic disease pseudohypoaldosteronism type 2 ductal breast carcinoma in situ medulloblastoma adenoma adrenal gland hyperfunction osteitis fibrosa atypical teratoid rhabdoid tumor ovarian cancer bile duct cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia testicular sex cord-stromal neoplasm pituitary cancer craniosynostosis Cushing syndrome due to macronodular adrenal hyperplasia fibrodysplasia ossificans progressiva gallstones oligodendroglioma schizophrenia growth hormone secreting pituitary adenoma 1 osteogenesis imperfecta hemorrhagic disease pancreatic intraductal papillary-mucinous carcinoma Pick disease pituitary gland adenoma congenital anemia invasive ductal breast carcinoma cystic fibrosis malignant ependymoma pseudohypoaldosteronism type 1 ACTH-dependent Cushing syndrome endogenous depression fibrous dysplasia neurofibromatosis type 1 Alzheimer disease glioblastoma astrocytic tumor osteosarcoma autosomal recessive pseudohypoaldosteronism type 1 pancreatic intraductal papillary-mucinous neoplasm

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	��₂ adrenergic receptor fused to a Gs peptide

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.