6MSD | pdb_00006msd

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
S [auth u]	SCOP2B Superfamily	Ubiquitin-like	8101457	3000157	SCOP2B (2022-06-29)
T [auth w]	SCOP2B Superfamily	Ubiquitin-like	8101457	3000157	SCOP2B (2022-06-29)
JA [auth h]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064014	3000131	SCOP2B (2022-06-29)
V [auth H]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064014	3000131	SCOP2B (2022-06-29)
KA [auth i]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064036	3000131	SCOP2B (2022-06-29)
W [auth I]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064036	3000131	SCOP2B (2022-06-29)
LA [auth j]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064004	3000131	SCOP2B (2022-06-29)
X [auth J]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064004	3000131	SCOP2B (2022-06-29)
MA [auth k]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064022	3000131	SCOP2B (2022-06-29)
Y [auth K]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064022	3000131	SCOP2B (2022-06-29)
Z [auth L]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064060	3000131	SCOP2B (2022-06-29)
NA [auth l]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064060	3000131	SCOP2B (2022-06-29)
OA [auth m]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064054	3000131	SCOP2B (2022-06-29)
AA [auth M]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064054	3000131	SCOP2B (2022-06-29)
BA [auth N]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079175	3000131	SCOP2B (2022-06-29)
PA [auth n]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079175	3000131	SCOP2B (2022-06-29)
CA [auth O]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064074	3000131	SCOP2B (2022-06-29)
QA [auth o]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064074	3000131	SCOP2B (2022-06-29)
FA [auth R]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079492	3000131	SCOP2B (2022-06-29)
TA [auth r]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079492	3000131	SCOP2B (2022-06-29)
D [auth X]	SCOP2B Superfamily	Winged helix DNA-binding domain	8067905	3000034	SCOP2B (2022-06-29)
E [auth Y]	SCOP2B Superfamily	TPR-like	8057045	3001345	SCOP2B (2022-06-29)
E [auth Y]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057047	3000034	SCOP2B (2022-06-29)
F [auth Z]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053251	3002167	SCOP2B (2022-06-29)
F [auth Z]	SCOP2B Superfamily	JAB1/MPN domain-like	8053252	3001105	SCOP2B (2022-06-29)
I [auth c]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053254	3002167	SCOP2B (2022-06-29)
I [auth c]	SCOP2B Superfamily	JAB1/MPN domain-like	8053255	3001105	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth U]	KOG2062_2nd	e6msdU3	A: beta sandwiches	X: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	H: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 C-terminal domain	F: KOG2062_2nd	ECOD (1.6)
A [auth U]	KOG2062_1st	e6msdU1	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: KOG2062_1st	ECOD (1.6)
A [auth U]	HEAT_2_3	e6msdU2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: HEAT_2_3	ECOD (1.6)
J [auth d]	CSN8_PSD8_EIF3K_C_2	e6msdd2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: CSN8_PSD8_EIF3K_C_2	ECOD (1.6)
J [auth d]	SAC3_GANP_1st	e6msdd1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: SAC3_GANP_1st	ECOD (1.6)
L [auth f]	KOG2005_1st	e6msdf3	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: KOG2005_1st	ECOD (1.6)
L [auth f]	KOG1858_2nd	e6msdf1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: KOG1858_2nd	ECOD (1.6)
M [auth A]	PRK03992	e6msdA1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PRK03992	ECOD (1.6)
M [auth A]	Sigma54_activat	e6msdA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sigma54_activat	ECOD (1.6)
P [auth D]	26Sp45	e6msdD2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: 26Sp45	ECOD (1.6)
P [auth D]	PRK03992	e6msdD1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PRK03992	ECOD (1.6)
P [auth D]	Sigma54_activat	e6msdD3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sigma54_activat	ECOD (1.6)
Q [auth E]	26Sp45	e6msdE1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: 26Sp45	ECOD (1.6)
Q [auth E]	KOG0652_2nd	e6msdE2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: KOG0652_2nd	ECOD (1.6)
Q [auth E]	Sigma54_activat	e6msdE3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sigma54_activat	ECOD (1.6)
S [auth u]	ubiquitin_1	e6msdu1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_1	ECOD (1.6)
T [auth w]	ubiquitin_1	e6msdw1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_1	ECOD (1.6)
B [auth V]	PCI	e6msdV3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PCI	ECOD (1.6)
B [auth V]	KOG2581	e6msdV1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG2581	ECOD (1.6)
B [auth V]	Rpn3_C	e6msdV2	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN3 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN3 C-terminal helix	F: Rpn3_C	ECOD (1.6)
IA [auth g]	Proteasome	e6msdg1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
U [auth G]	Proteasome	e6msdG1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
JA [auth h]	Proteasome	e6msdh1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
V [auth H]	Proteasome	e6msdH1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
KA [auth i]	Proteasome	e6msdi1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
W [auth I]	Proteasome	e6msdI1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
LA [auth j]	Proteasome	e6msdj1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
X [auth J]	Proteasome	e6msdJ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
MA [auth k]	Proteasome	e6msdk1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
Y [auth K]	Proteasome	e6msdK1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
Z [auth L]	Proteasome	e6msdL1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
NA [auth l]	Proteasome	e6msdl1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
OA [auth m]	Proteasome	e6msdm1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
AA [auth M]	Proteasome	e6msdM1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
BA [auth N]	Proteasome	e6msdN1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
PA [auth n]	Proteasome	e6msdn1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
CA [auth O]	Proteasome	e6msdO1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
QA [auth o]	Proteasome	e6msdo1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
DA [auth P]	Proteasome	e6msdP1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
RA [auth p]	Proteasome	e6msdp1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
C [auth W]	PCI	e6msdW3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PCI	ECOD (1.6)
C [auth W]	RPN7_1	e6msdW2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RPN7_1	ECOD (1.6)
C [auth W]	KOG1498	e6msdW1	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN5 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN5 C-terminal helix	F: KOG1498	ECOD (1.6)
EA [auth Q]	Proteasome	e6msdQ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
SA [auth q]	Proteasome	e6msdq1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
FA [auth R]	Proteasome	e6msdR1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
TA [auth r]	Proteasome	e6msdr1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
UA [auth s]	Proteasome	e6msds1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
GA [auth S]	Proteasome	e6msdS1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
VA [auth t]	Proteasome	e6msdt1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
HA [auth T]	Proteasome	e6msdT1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: Proteasome	ECOD (1.6)
D [auth X]	PCI	e6msdX3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PCI	ECOD (1.6)
D [auth X]	KOG1463	e6msdX1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG1463	ECOD (1.6)
D [auth X]	RPN6_like	e6msdX2	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN6 C-termial helix (From Topology)	T: 26S proteasome regulatory subunit RPN6 C-termial helix	F: RPN6_like	ECOD (1.6)
E [auth Y]	PCI_1	e6msdY1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PCI_1	ECOD (1.6)
E [auth Y]	RPN7	e6msdY2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RPN7	ECOD (1.6)
E [auth Y]	KOG0687	e6msdY3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN7 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN7 C-terminal helix	F: KOG0687	ECOD (1.6)
F [auth Z]	JAB	e6msdZ1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: JAB	ECOD (1.6)
F [auth Z]	MitMem_reg	e6msdZ2	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: MitMem_reg	ECOD (1.6)
G [auth a]	PCI_1	e6msda3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PCI_1	ECOD (1.6)
G [auth a]	KOG2908_N	e6msda2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG2908_N	ECOD (1.6)
G [auth a]	KOG2908_C	e6msda1	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN9 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN9 C-terminal helix	F: KOG2908_C	ECOD (1.6)
H [auth b]	VWA	e6msdb1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)
I [auth c]	JAB	e6msdc2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: JAB	ECOD (1.6)
I [auth c]	EUF08560	e6msdc1	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: EUF08560	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth U]	PF13646	HEAT repeats (HEAT_2)	HEAT repeats	-	Repeat
A [auth U]	PF18004	26S proteasome regulatory subunit RPN2 C-terminal domain (RPN2_C)	26S proteasome regulatory subunit RPN2 C-terminal domain	This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating inter ...	This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating interactions with the ubiquitin-binding subunit Rpn13. Futhermore, the extreme C-terminal 20 or 21 residues of Rpn2 (926-945 or 925-945) of S. cerevisiae, were shown to be equally effective at binding Rpn13. Multiple sequence alignments indicate that Rpn2 orthologs are highly conserved in this C-terminal region and share characteristic acidic, aromatic, and proline residues, suggesting a common function. In the structure of Rpn2 from S. cerevisiae , this region is exposed and disordered, and is thus accessible for associating with Rpn13. The Rpn2 binding surface of human Rpn13 has been mapped by nuclear magnetic resonance titration to one surface of its Pru domain [1].	Domain
A [auth U]	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
A [auth U]	PF01851	Proteasome/cyclosome repeat (PC_rep)	Proteasome/cyclosome repeat	-	Repeat
M [auth A]	PF22037	PSD13 N-terminal repeats (PSD13_N)	PSD13 N-terminal repeats	-	Repeat
M [auth A]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
M [auth A]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
M [auth A]	PF21236	26S proteasome regulatory subunit 7, OB domain (PRS7_OB)	26S proteasome regulatory subunit 7, OB domain	This is the OB domain from 26S proteasome regulatory subunit 7 (PRS7, also known as PSMC2, Rpt1 or MSS1), a component of the 19S proteasome cap [1-5]. These are one of six ATPases of the regulatory particle that form a heterohexameric ring. This doma ...	This is the OB domain from 26S proteasome regulatory subunit 7 (PRS7, also known as PSMC2, Rpt1 or MSS1), a component of the 19S proteasome cap [1-5]. These are one of six ATPases of the regulatory particle that form a heterohexameric ring. This domain mediates interactions with USP14 or Ubp6 [2,4].	Domain
M [auth A]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
N [auth B]	PF13519	von Willebrand factor type A domain (VWA_2)	von Willebrand factor type A domain		Domain
N [auth B]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
N [auth B]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
N [auth B]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
O [auth C]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
O [auth C]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	Proteins with this domain are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. This domain is known as the MPN domain [3] and PAD-1-like domain [4], JABP1 domain [5] or J ...	Proteins with this domain are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. This domain is known as the MPN domain [3] and PAD-1-like domain [4], JABP1 domain [5] or JAMM domain [7]. These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signalling and protein turnover pathways in eukaryotes [7]. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are shown to have a similar role, and the archaeal protein from Haloferax volcanii is found to cleave ubiquitin-like small archaeal modifier proteins (SAMP1/2) from protein conjugates [8,9].	Domain
O [auth C]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
O [auth C]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
P [auth D]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
P [auth D]	PF10075	CSN8/PSMD8/EIF3K family (CSN8_PSD8_EIF3K)	CSN8/PSMD8/EIF3K family	-	Family
P [auth D]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
P [auth D]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
Q [auth E]	PF05160	DSS1/SEM1 family (DSS1_SEM1)	DSS1/SEM1 family	-	Family
Q [auth E]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
Q [auth E]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
Q [auth E]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
R [auth F]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
R [auth F]	PF17781	RPN1 N-terminal domain (RPN1_RPN2_N)	RPN1 N-terminal domain	-	Repeat
R [auth F]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
R [auth F]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
B [auth V]	PF08375	Proteasome regulatory subunit C-terminal (Rpn3_C)	Proteasome regulatory subunit C-terminal	-	Family
B [auth V]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
IA [auth g], U [auth G]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
IA [auth g], U [auth G]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
JA [auth h], V [auth H]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
JA [auth h], V [auth H]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
KA [auth i], W [auth I]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
KA [auth i], W [auth I]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
LA [auth j], X [auth J]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
LA [auth j], X [auth J]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
MA [auth k], Y [auth K]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
MA [auth k], Y [auth K]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
NA [auth l], Z [auth L]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
NA [auth l], Z [auth L]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
AA [auth M], OA [auth m]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
AA [auth M], OA [auth m]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
CA [auth O], QA [auth o]	PF12465	Proteasome beta subunits C terminal (Pr_beta_C)	Proteasome beta subunits C terminal	-	Family
DA [auth P], RA [auth p]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
C [auth W]	PF18098	26S proteasome regulatory subunit RPN5 C-terminal domain (RPN5_C)	26S proteasome regulatory subunit RPN5 C-terminal domain	This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degrada ...	This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degradation machine: the lid, the base, and the core. The helices found at the C terminus of each lid subunit form a helical bundle that directs the ordered self-assembly of the lid subcomplex. This domain which comprises the tail of RPN5 along with the tail of Rpn9, are important for Rpn12 binding to the lid [1].	Domain
C [auth W]	PF22241	PSMD12/CSN4, N-terminal (PSMD12-CSN4_N)	PSMD12/CSN4, N-terminal	-	Repeat
C [auth W]	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
C [auth W]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
EA [auth Q], SA [auth q]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
GA [auth S], UA [auth s]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
HA [auth T], VA [auth t]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
D [auth X]	PF18503	26S proteasome subunit RPN6 C-terminal helix domain (RPN6_C_helix)	26S proteasome subunit RPN6 C-terminal helix domain	This is the C-terminal helix domain found in RPN6, a component of the 26S proteasome. The C-terminal helices are essential for lid assembly [1, 2].	Domain
D [auth X]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
E [auth Y]	PF21154	26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix (RPN7_PSMD6_C)	26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix	RPN7/PSDM6 are regulatory subunits from the 26S proteasome. This entry represents the C-terminal helix.	Domain
E [auth Y]	PF10602	26S proteasome subunit RPN7 (RPN7)	26S proteasome subunit RPN7	-	Repeat
E [auth Y]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
F [auth Z]	PF13012	Maintenance of mitochondrial structure and function (MitMem_reg)	Maintenance of mitochondrial structure and function	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth U]	26S proteasome non-ATPase regulatory subunit 1	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding enzyme regulator activity molecular function regulator activity catalytic activity	regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex cytoplasm proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen organelle secretory granule primary lysosome secretory vesicle membraneless organelle intracellular membraneless organelle proteasome storage granule nucleus nucleoplasm nuclear lumen
J [auth d]	26S proteasome non-ATPase regulatory subunit 8	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol proteasome accessory complex protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol proteasome accessory complex protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
K [auth e]	26S proteasome complex subunit SEM1	-	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle integrator complex organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
L [auth f]	26S proteasome non-ATPase regulatory subunit 2	enzyme regulator activity molecular function regulator activity catalytic activity	regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex extracellular exosome proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol membraneless organelle intracellular membraneless organelle proteasome storage granule ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
M [auth A]	26S proteasome regulatory subunit 7	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen membraneless organelle cytoplasmic ribonucleoprotein granule intracellular membraneless organelle supramolecular complex ribonucleoprotein granule extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen P-body
N [auth B]	26S proteasome regulatory subunit 4	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity RNA binding nucleic acid binding polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
O [auth C]	26S proteasome regulatory subunit 8	transcription factor binding protein binding binding general transcription initiation factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding transcription factor binding protein binding binding general transcription initiation factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA-binding transcription factor binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity peptide hormone receptor binding signaling receptor binding G protein-coupled receptor binding thyrotropin-releasing hormone receptor binding hormone receptor binding polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process regulation of protein catabolic process negative regulation of programmed cell death regulation of programmed cell death cell death programmed cell death proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytoplasmic vesicle intracellular vesicle blood microparticle
P [auth D]	26S proteasome regulatory subunit 6B	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development proteolysis metabolic process cellular process primary metabolic process protein metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular membraneless organelle cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton
Q [auth E]	26S proteasome regulatory subunit 10B	protein-macromolecule adaptor activity molecular adaptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding protein-macromolecule adaptor activity molecular adaptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process cellular response to stimulus response to stimulus response to nitrogen compound ERAD pathway cellular response to stress response to chemical response to stress response to endoplasmic reticulum stress positive regulation of cellular component organization regulation of cellular component organization positive regulation of cellular component biogenesis regulation of inclusion body assembly inclusion body assembly regulation of cellular component biogenesis cellular component biogenesis cellular component organization cellular component assembly positive regulation of inclusion body assembly cellular component organization or biogenesis transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of RNA polymerase II transcription preinitiation complex assembly positive regulation of DNA-templated transcription RNA metabolic process protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol inclusion body nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytosolic proteasome complex
R [auth F]	26S proteasome regulatory subunit 6A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	modulation by host of viral transcription viral gene expression modulation by host of viral process biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription viral process negative regulation by host of viral process modulation of process of another organism viral transcription host-mediated perturbation of symbiont process positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process modulation by host of viral transcription viral gene expression modulation by host of viral process biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription viral process negative regulation by host of viral process modulation of process of another organism viral transcription host-mediated perturbation of symbiont process positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule membraneless organelle supramolecular complex P-body
S [auth u], T [auth w]	Ubiquitin	protein tag activity molecular tag activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	developmental process multicellular organismal process reproductive system development gonad development tube development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics seminiferous tubule development developmental process multicellular organismal process reproductive system development gonad development tube development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics seminiferous tubule development anatomical structure development reproductive structure development system development regulation of mitochondrial membrane potential biological regulation regulation of biological quality regulation of membrane potential catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process cellular process macromolecule metabolic process protein metabolic process regulation of biological process neuron apoptotic process regulation of cellular process regulation of apoptotic process regulation of programmed cell death cell death apoptotic process programmed cell death regulation of neuron apoptotic process multicellular organismal-level homeostasis homeostatic process energy homeostasis regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process protein ubiquitination positive regulation of macromolecule metabolic process regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of cellular process positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification regulation of protein metabolic process regulation of macromolecule metabolic process macromolecule modification post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of signal transduction regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction intrinsic apoptotic signaling pathway regulation of signaling positive regulation of programmed cell death positive regulation of intracellular signal transduction signal transduction by p53 class mediator positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of intrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway positive regulation of signaling cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis plasma membrane bounded cell projection organization nervous system development generation of neurons anatomical structure morphogenesis neuron development hypothalamus development forebrain development central nervous system neuron development central nervous system neuron differentiation hypothalamus cell differentiation hypothalamus gonadotrophin-releasing hormone neuron development limbic system development head development forebrain generation of neurons hypothalamus gonadotrophin-releasing hormone neuron differentiation brain development diencephalon development forebrain neuron development central nervous system development forebrain neuron differentiation sexual reproduction organelle fission meiotic cell cycle multicellular organismal reproductive process female gamete generation meiotic cell cycle process gamete generation nuclear division organelle organization meiosis I meiosis I cell cycle process female meiosis I female meiotic nuclear division meiotic nuclear division cell cycle cell cycle process positive regulation of protein monoubiquitination protein monoubiquitination regulation of protein monoubiquitination regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteasomal protein catabolic process regulation of catabolic process regulation of proteasomal protein catabolic process regulation of protein catabolic process male meiosis I male meiotic nuclear division male gamete generation connective tissue development adipose tissue development fat pad development tissue development female gonad development female sex differentiation development of primary female sexual characteristics establishment of organelle localization cellular localization organelle transport along microtubule transport establishment of mitochondrion localization intracellular transport establishment of localization localization mitochondrion localization establishment of mitochondrion localization, microtubule-mediated mitochondrion transport along microtubule organelle localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cell projection neuron projection plasma membrane bounded cell projection intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane endocytic vesicle endosome membrane endosome mitochondrial membrane organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane somatodendritic compartment cell body neuronal cell body
B [auth V]	26S proteasome non-ATPase regulatory subunit 3	enzyme regulator activity molecular function regulator activity catalytic activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process regulation of biological process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process regulation of biological process regulation of cellular process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of primary metabolic process regulation of metabolic process regulation of protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
IA [auth g], U [auth G]	Proteasome subunit alpha type-6	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding RNA binding nucleic acid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity purine ribonucleoside triphosphate binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding RNA binding nucleic acid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding anion binding heterocyclic compound binding small molecule binding	catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of DNA-binding transcription factor activity regulation of cellular process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process regulation of defense response response to stimulus regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stimulus response to stress regulation of response to stress inflammatory response	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell projection cilium plasma membrane bounded cell projection nucleus membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell projection cilium plasma membrane bounded cell projection nucleus membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear lumen nuclear matrix protein-containing complex proteasome core complex, alpha-subunit complex catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol nucleoplasm membraneless organelle intracellular membraneless organelle ribosome sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule P-body
JA [auth h], V [auth H]	Proteasome subunit alpha type-2	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule membraneless organelle supramolecular complex P-body ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
KA [auth i], W [auth I]	Proteasome subunit alpha type-4	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol intracellular organelle intracellular membrane-bounded organelle cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule membraneless organelle supramolecular complex P-body nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
LA [auth j], X [auth J]	Proteasome subunit alpha type-7	identical protein binding protein binding binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
MA [auth k], Y [auth K]	Proteasome subunit alpha type-5	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
NA [auth l], Z [auth L]	Proteasome subunit alpha type-1	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	immune system process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response immune system process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus biological regulation response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
AA [auth M], OA [auth m]	Proteasome subunit alpha type-3	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
BA [auth N], PA [auth n]	Proteasome subunit beta type-6	cell adhesion molecule binding cadherin binding protein binding binding peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
CA [auth O], QA [auth o]	Proteasome subunit beta type-7	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region vesicle lumen membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus nuclear body nucleoplasm nuclear lumen ficolin-1-rich granule ficolin-1-rich granule lumen
DA [auth P], RA [auth p]	Proteasome subunit beta type-3	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
C [auth W]	26S proteasome non-ATPase regulatory subunit 12	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
EA [auth Q], SA [auth q]	Proteasome subunit beta type-2	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
FA [auth R], TA [auth r]	Proteasome subunit beta type-5	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis response to oxidative stress response to stimulus response to stress proteolysis metabolic process primary metabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis response to oxidative stress response to stimulus response to stress proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
GA [auth S], UA [auth s]	Proteasome subunit beta type-1	-	catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
HA [auth T], VA [auth t]	Proteasome subunit beta type-4	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus biological regulation response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen intracellular membraneless organelle cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton
D [auth X]	26S proteasome non-ATPase regulatory subunit 11	structural molecule activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process cellular component organization catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis developmental process stem cell differentiation cellular developmental process cell differentiation proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
E [auth Y]	26S proteasome non-ATPase regulatory subunit 6	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
F [auth Z]	26S proteasome non-ATPase regulatory subunit 7	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure membrane proteasome accessory complex intracellular anatomical structure proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure membrane proteasome accessory complex intracellular anatomical structure proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
G [auth a]	26S proteasome non-ATPase regulatory subunit 13	structural molecule activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process sexual reproduction catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization meiosis I meiosis I cell cycle process meiotic nuclear division cell cycle cellular component organization or biogenesis cell cycle process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
H [auth b]	26S proteasome non-ATPase regulatory subunit 4	polyubiquitin modification-dependent protein binding protein binding binding modification-dependent protein binding molecular adaptor activity RNA binding nucleic acid binding identical protein binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
I [auth c]	26S proteasome non-ATPase regulatory subunit 14	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity protein-containing complex binding binding proteasome binding enzyme regulator activity peptidase regulator activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity protein-containing complex binding binding proteasome binding enzyme regulator activity peptidase regulator activity molecular function activator activity peptidase activator activity endopeptidase regulator activity endopeptidase activator activity enzyme activator activity molecular function regulator activity endopeptidase activity cation binding ion binding metal ion binding small molecule binding	protein deubiquitination protein K63-linked deubiquitination primary metabolic process protein modification by small protein removal macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal catabolic process proteolysis involved in protein catabolic process protein deubiquitination protein K63-linked deubiquitination primary metabolic process protein modification by small protein removal macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process response to stimulus response to alcohol response to chemical response to oxygen-containing compound response to ethanol cellular response to stimulus double-strand break repair DNA recombination DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair regulation of cellular process regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal protein catabolic process regulation of metabolic process regulation of protein catabolic process double-strand break repair via nonhomologous end joining	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen cytosolic proteasome complex extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth U]	IPR040623	26S proteasome regulatory subunit RPN2, C-terminal	Domain
A [auth U]	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth U]	IPR002015	Proteasome/cyclosome repeat	Repeat
A [auth U]	IPR011989	Armadillo-like helical	Homologous Superfamily
A [auth U]	IPR048570	26S proteasome non-ATPase regulatory subunit 1/RPN2, N-terminal domain	Domain
A [auth U]	IPR016642	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit	Family
J [auth d]	IPR000717	Proteasome component (PCI) domain	Domain
J [auth d]	IPR006746	26S proteasome non-ATPase regulatory subunit Rpn12	Family
J [auth d]	IPR033464	CSN8/PSMD8/EIF3K	Domain
K [auth e]	IPR007834	DSS1/SEM1	Family
L [auth f]	IPR041433	26S proteasome non-ATPase regulatory subunit RPN1, C-terminal	Domain
L [auth f]	IPR016024	Armadillo-type fold	Homologous Superfamily
L [auth f]	IPR002015	Proteasome/cyclosome repeat	Repeat
L [auth f]	IPR016643	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit	Family
L [auth f]	IPR011989	Armadillo-like helical	Homologous Superfamily
L [auth f]	IPR040892	RPN1, N-terminal	Domain
M [auth A]	IPR050221	26S Proteasome Regulatory ATPase	Family
M [auth A]	IPR003593	AAA+ ATPase domain	Domain
M [auth A]	IPR003959	ATPase, AAA-type, core	Domain
M [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
M [auth A]	IPR048723	26S proteasome regulatory subunit 7-like, OB domain	Domain
M [auth A]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
M [auth A]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
M [auth A]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
N [auth B]	IPR050221	26S Proteasome Regulatory ATPase	Family
N [auth B]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
N [auth B]	IPR032501	Proteasomal ATPase, second OB domain	Domain
N [auth B]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
N [auth B]	IPR003593	AAA+ ATPase domain	Domain
N [auth B]	IPR003959	ATPase, AAA-type, core	Domain
N [auth B]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
N [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
O [auth C]	IPR050221	26S Proteasome Regulatory ATPase	Family
O [auth C]	IPR003593	AAA+ ATPase domain	Domain
O [auth C]	IPR003959	ATPase, AAA-type, core	Domain
O [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
O [auth C]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
O [auth C]	IPR032501	Proteasomal ATPase, second OB domain	Domain
O [auth C]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
O [auth C]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
P [auth D]	IPR050221	26S Proteasome Regulatory ATPase	Family
P [auth D]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
P [auth D]	IPR032501	Proteasomal ATPase, second OB domain	Domain
P [auth D]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
P [auth D]	IPR003593	AAA+ ATPase domain	Domain
P [auth D]	IPR003959	ATPase, AAA-type, core	Domain
P [auth D]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
P [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
Q [auth E]	IPR050221	26S Proteasome Regulatory ATPase	Family
Q [auth E]	IPR003593	AAA+ ATPase domain	Domain
Q [auth E]	IPR003959	ATPase, AAA-type, core	Domain
Q [auth E]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
Q [auth E]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
Q [auth E]	IPR032501	Proteasomal ATPase, second OB domain	Domain
Q [auth E]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
Q [auth E]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
R [auth F]	IPR050221	26S Proteasome Regulatory ATPase	Family
R [auth F]	IPR003593	AAA+ ATPase domain	Domain
R [auth F]	IPR003959	ATPase, AAA-type, core	Domain
R [auth F]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
R [auth F]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
R [auth F]	IPR032501	Proteasomal ATPase, second OB domain	Domain
R [auth F]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
R [auth F]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
S [auth u], T [auth w]	IPR019954	Ubiquitin conserved site	Conserved Site
S [auth u], T [auth w]	IPR050158	Ubiquitin and ubiquitin-like	Family
S [auth u], T [auth w]	IPR000626	Ubiquitin-like domain	Domain
S [auth u], T [auth w]	IPR019956	Ubiquitin domain	Domain
S [auth u], T [auth w]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B [auth V]	IPR013586	26S proteasome regulatory subunit, C-terminal	Domain
B [auth V]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
B [auth V]	IPR050756	COP9 signalosome complex subunit 3	Family
B [auth V]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B [auth V]	IPR000717	Proteasome component (PCI) domain	Domain
IA [auth g], U [auth G]	IPR034642	Proteasome subunit alpha6	Family
IA [auth g], U [auth G]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
IA [auth g], U [auth G]	IPR050115	Proteasome subunit alpha	Family
IA [auth g], U [auth G]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
IA [auth g], U [auth G]	IPR023332	Proteasome alpha-type subunit	Family
IA [auth g], U [auth G]	IPR001353	Proteasome, subunit alpha/beta	Family
JA [auth h], V [auth H]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
JA [auth h], V [auth H]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
JA [auth h], V [auth H]	IPR050115	Proteasome subunit alpha	Family
JA [auth h], V [auth H]	IPR023332	Proteasome alpha-type subunit	Family
JA [auth h], V [auth H]	IPR001353	Proteasome, subunit alpha/beta	Family
KA [auth i], W [auth I]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
KA [auth i], W [auth I]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
KA [auth i], W [auth I]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
KA [auth i], W [auth I]	IPR050115	Proteasome subunit alpha	Family
KA [auth i], W [auth I]	IPR023332	Proteasome alpha-type subunit	Family
KA [auth i], W [auth I]	IPR001353	Proteasome, subunit alpha/beta	Family
LA [auth j], X [auth J]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
LA [auth j], X [auth J]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
LA [auth j], X [auth J]	IPR050115	Proteasome subunit alpha	Family
LA [auth j], X [auth J]	IPR023332	Proteasome alpha-type subunit	Family
LA [auth j], X [auth J]	IPR001353	Proteasome, subunit alpha/beta	Family
MA [auth k], Y [auth K]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
MA [auth k], Y [auth K]	IPR033812	Proteasome subunit alpha5	Family
MA [auth k], Y [auth K]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
MA [auth k], Y [auth K]	IPR050115	Proteasome subunit alpha	Family
MA [auth k], Y [auth K]	IPR023332	Proteasome alpha-type subunit	Family
MA [auth k], Y [auth K]	IPR001353	Proteasome, subunit alpha/beta	Family
NA [auth l], Z [auth L]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
NA [auth l], Z [auth L]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
NA [auth l], Z [auth L]	IPR050115	Proteasome subunit alpha	Family
NA [auth l], Z [auth L]	IPR035144	Proteasome subunit alpha 1	Family
NA [auth l], Z [auth L]	IPR023332	Proteasome alpha-type subunit	Family
NA [auth l], Z [auth L]	IPR001353	Proteasome, subunit alpha/beta	Family
AA [auth M], OA [auth m]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
AA [auth M], OA [auth m]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
AA [auth M], OA [auth m]	IPR050115	Proteasome subunit alpha	Family
AA [auth M], OA [auth m]	IPR023332	Proteasome alpha-type subunit	Family
AA [auth M], OA [auth m]	IPR001353	Proteasome, subunit alpha/beta	Family
BA [auth N], PA [auth n]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
BA [auth N], PA [auth n]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
BA [auth N], PA [auth n]	IPR023333	Proteasome B-type subunit	Family
BA [auth N], PA [auth n]	IPR001353	Proteasome, subunit alpha/beta	Family
BA [auth N], PA [auth n]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
CA [auth O], QA [auth o]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
CA [auth O], QA [auth o]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
CA [auth O], QA [auth o]	IPR024689	Proteasome beta subunit, C-terminal	Domain
CA [auth O], QA [auth o]	IPR023333	Proteasome B-type subunit	Family
CA [auth O], QA [auth o]	IPR001353	Proteasome, subunit alpha/beta	Family
CA [auth O], QA [auth o]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
DA [auth P], RA [auth p]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
DA [auth P], RA [auth p]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
DA [auth P], RA [auth p]	IPR023333	Proteasome B-type subunit	Family
DA [auth P], RA [auth p]	IPR001353	Proteasome, subunit alpha/beta	Family
DA [auth P], RA [auth p]	IPR033811	Proteasome beta 3 subunit	Family
C [auth W]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth W]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth W]	IPR000717	Proteasome component (PCI) domain	Domain
C [auth W]	IPR040896	26S proteasome regulatory subunit RPN5, C-terminal domain	Domain
C [auth W]	IPR040134	26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4	Family
C [auth W]	IPR054559	PSMD12/CSN4-like, N-terminal	Domain
EA [auth Q], SA [auth q]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
EA [auth Q], SA [auth q]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
EA [auth Q], SA [auth q]	IPR023333	Proteasome B-type subunit	Family
EA [auth Q], SA [auth q]	IPR001353	Proteasome, subunit alpha/beta	Family
EA [auth Q], SA [auth q]	IPR035206	Proteasome subunit beta 2	Family
FA [auth R], TA [auth r]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
FA [auth R], TA [auth r]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
FA [auth R], TA [auth r]	IPR023333	Proteasome B-type subunit	Family
FA [auth R], TA [auth r]	IPR001353	Proteasome, subunit alpha/beta	Family
FA [auth R], TA [auth r]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
GA [auth S], UA [auth s]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
GA [auth S], UA [auth s]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
GA [auth S], UA [auth s]	IPR023333	Proteasome B-type subunit	Family
GA [auth S], UA [auth s]	IPR001353	Proteasome, subunit alpha/beta	Family
HA [auth T], VA [auth t]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
HA [auth T], VA [auth t]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
HA [auth T], VA [auth t]	IPR023333	Proteasome B-type subunit	Family
HA [auth T], VA [auth t]	IPR016295	Proteasome subunit beta 4	Family
HA [auth T], VA [auth t]	IPR001353	Proteasome, subunit alpha/beta	Family
D [auth X]	IPR050871	26S Proteasome and COP9 Signalosome Components	Family
D [auth X]	IPR040780	6S proteasome subunit Rpn6, C-terminal helix domain	Domain
D [auth X]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
D [auth X]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
D [auth X]	IPR040773	26S proteasome regulatory subunit Rpn6, N-terminal	Domain
D [auth X]	IPR000717	Proteasome component (PCI) domain	Domain
E [auth Y]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
E [auth Y]	IPR019585	26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1	Family
E [auth Y]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
E [auth Y]	IPR049549	26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix	Domain
E [auth Y]	IPR000717	Proteasome component (PCI) domain	Domain
E [auth Y]	IPR045135	26S proteasome regulatory subunit Rpn7, N-terminal	Domain
F [auth Z]	IPR033858	26S Proteasome non-ATPase regulatory subunit 7/8	Family
F [auth Z]	IPR024969	EIF3F/CSN6-like, C-terminal	Domain
F [auth Z]	IPR037518	MPN domain	Domain
F [auth Z]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
G [auth a]	IPR054179	PSD13, N-terminal	Domain
G [auth a]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
G [auth a]	IPR035298	26S Proteasome non-ATPase regulatory subunit 13	Family
G [auth a]	IPR000717	Proteasome component (PCI) domain	Domain
H [auth b]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
H [auth b]	IPR027040	26S proteasome non-ATPase regulatory subunit 4	Family
H [auth b]	IPR002035	von Willebrand factor, type A	Domain
H [auth b]	IPR003903	Ubiquitin interacting motif	Conserved Site
H [auth b]	IPR049590	PSMD4, RAZUL domain	Domain
I [auth c]	IPR056263	26S proteasome regulatory subunit RPN11, C-terminal domain	Domain
I [auth c]	IPR050242	JAMM/MPN+ metalloenzymes, peptidase M67A	Family
I [auth c]	IPR037518	MPN domain	Domain
I [auth c]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth U]	Pharos: Q99460	dermatomyositis osteosarcoma psoriasis lung adenocarcinoma ovarian cancer lung cancer pancreatic intraductal papillary-mucinous neoplasm
J [auth d]	Pharos: P48556	HIV infectious disease glioblastoma ovarian cancer Sjogren syndrome HIV Coinfection pancreatic ductal adenocarcinoma plasma cell myeloma
K [auth e]	Pharos: P60896	squamous cell carcinoma bone disease non-small cell lung carcinoma split hand-foot malformation lung cancer osteoporosis medulloblastoma pneumonia subependymal giant cell astrocytoma
L [auth f]	Pharos: Q13200	breast cancer ovarian cancer lung cancer psoriasis non-small cell lung carcinoma
M [auth A]	Pharos: P35998	dermatomyositis osteosarcoma plasma cell myeloma lung cancer ovarian cancer psoriasis malignant mesothelioma pancreatic ductal adenocarcinoma
O [auth C]	Pharos: P62195	Stevens-Johnson syndrome HIV infectious disease colorectal cancer plasma cell myeloma toxic epidermal necrolysis Drug-Induced Stevens Johnson Syndrome ovarian cancer
P [auth D]	Pharos: P43686	astrocytic tumor Hodgkins lymphoma diabetes mellitus osteosarcoma glioblastoma ovarian cancer
R [auth F]	Pharos: P17980	HIV infectious disease cataract HIV Coinfection lung cancer ovarian cancer prostate carcinoma cerebrovascular disorder metabolic syndrome X peripheral neuropathy subependymal giant cell astrocytoma endogenous depression hypertensive disorder open-angle glaucoma plasma cell myeloma
S [auth u], T [auth w]	Pharos: P0CG47	astrocytic tumor cleft soft palate lung cancer Cleft of hard palate ovarian cancer isolated cleft palate
B [auth V]	Pharos: O43242	HIV infectious disease acute lymphoblastic leukemia cervical cancer dermatomyositis lung adenocarcinoma ulcerative colitis allergic rhinitis chronic obstructive pulmonary disease HIV Coinfection rheumatoid arthritis breast carcinoma Crohn disease systemic sclerosis
IA [auth g], U [auth G]	Pharos: P60900	HIV infectious disease myocardial infarction HIV Coinfection psoriasis
JA [auth h], V [auth H]	Pharos: P25787	osteoporosis heart disease breast cancer malignant mesothelioma Osteoporosis, Senile psoriasis colorectal cancer ovarian cancer
KA [auth i], W [auth I]	Pharos: P25789	Mammary Neoplasms, Experimental sarcomatoid carcinoma adult acute respiratory distress syndrome carcinoma HIV infectious disease liver cancer lung carcinoma mammary neoplasms, animal ovarian cancer polycystic ovary syndrome abdominal aortic aneurysm small cell lung carcinoma bipolar disorder bronchitis chronic obstructive pulmonary disease Mammary Neoplasms, Experimental sarcomatoid carcinoma adult acute respiratory distress syndrome carcinoma HIV infectious disease liver cancer lung carcinoma mammary neoplasms, animal ovarian cancer polycystic ovary syndrome abdominal aortic aneurysm small cell lung carcinoma bipolar disorder bronchitis chronic obstructive pulmonary disease liver neoplasm lymphoplasmacytic lymphoma peripheral arterial disease squamous cell lung carcinoma anorexia nervosa brain aneurysm dental caries lung adenocarcinoma nicotine dependence plasma cell myeloma Sjogren syndrome undifferentiated carcinoma autism spectrum disorder breast cancer dermatomyositis
LA [auth j], X [auth J]	Pharos: O14818	breast cancer lung cancer pancreatic intraductal papillary-mucinous carcinoma glioblastoma medulloblastoma plasma cell myeloma intellectual disability ovarian cancer Sjogren syndrome
MA [auth k], Y [auth K]	Pharos: P28066	HIV infectious disease osteoporosis non-small cell lung carcinoma Osteoporosis, Age-Related ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Alzheimer disease pilocytic astrocytoma cystic fibrosis primitive neuroectodermal tumor fatty liver disease tuberculosis glioblastoma lung cancer malignant glioma HIV infectious disease osteoporosis non-small cell lung carcinoma Osteoporosis, Age-Related ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Alzheimer disease pilocytic astrocytoma cystic fibrosis primitive neuroectodermal tumor fatty liver disease tuberculosis glioblastoma lung cancer malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor pituitary cancer diabetes mellitus psoriasis gastric cancer hepatocellular carcinoma invasive ductal breast carcinoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma malignant ependymoma
NA [auth l], Z [auth L]	Pharos: P25786	mantle cell lymphoma plasma cell myeloma Systemic AL amyloidosis
AA [auth M], OA [auth m]	Pharos: P25788	attention deficit hyperactivity disorder, inattentive type lymphoplasmacytic lymphoma pancreatic ductal adenocarcinoma Sjogren syndrome dermatomyositis osteosarcoma plasma cell myeloma heart disease ovarian cancer psoriasis
BA [auth N], PA [auth n]	Pharos: P28072	attention deficit hyperactivity disorder, inattentive type ovarian cancer psoriasis brain aneurysm pancreatic ductal adenocarcinoma Sjogren syndrome lung cancer plasma cell myeloma systemic lupus erythematosus
CA [auth O], QA [auth o]	Pharos: Q99436	atrial fibrillation allergic rhinitis hepatocellular carcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease plasma cell myeloma astrocytic tumor hypothyroidism oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy vitiligo lymphoplasmacytic lymphoma ovarian cancer atrial fibrillation allergic rhinitis hepatocellular carcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease plasma cell myeloma astrocytic tumor hypothyroidism oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy vitiligo lymphoplasmacytic lymphoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Pick disease
DA [auth P], RA [auth p]	Pharos: P49720	chronic obstructive pulmonary disease lymphoplasmacytic lymphoma diabetes mellitus ovarian cancer glioblastoma plasma cell myeloma
C [auth W]	Pharos: O00232	contact dermatitis atypical teratoid rhabdoid tumor intellectual disability non-small cell lung carcinoma pancreatic ductal adenocarcinoma psoriasis invasive ductal breast carcinoma osteosarcoma Parkinson disease Stankiewicz-Isidor syndrome Contact hypersensitivity lung cancer ovarian cancer plasma cell myeloma
EA [auth Q], SA [auth q]	Pharos: P49721	urinary bladder cancer atypical teratoid rhabdoid tumor glioblastoma lung carcinoma osteosarcoma Sjogren syndrome breast cancer invasive ductal breast carcinoma malignant mesothelioma ovarian cancer Systemic AL amyloidosis urinary bladder neoplasm diabetes mellitus large cell medulloblastoma mantle cell lymphoma urinary bladder cancer atypical teratoid rhabdoid tumor glioblastoma lung carcinoma osteosarcoma Sjogren syndrome breast cancer invasive ductal breast carcinoma malignant mesothelioma ovarian cancer Systemic AL amyloidosis urinary bladder neoplasm diabetes mellitus large cell medulloblastoma mantle cell lymphoma plasma cell myeloma systemic lupus erythematosus
FA [auth R], TA [auth r]	Pharos: P28074	plasma cell myeloma acute lymphoblastic leukemia diabetes mellitus mantle cell lymphoma ovarian cancer Relapse multiple myeloma B-cell acute lymphoblastic leukemia hypertensive disorder medulloblastoma coronary artery disease lung cancer myocardial ischemia psoriasis
GA [auth S], UA [auth s]	Pharos: P20618	acute coronary syndrome peripheral neuropathy plasma cell myeloma peripheral nervous system disease lymphoplasmacytic lymphoma osteoarthritis ovarian cancer dermatomyositis malignant colon neoplasm osteoarthritis susceptibility 1 pancreatic ductal adenocarcinoma glioblastoma mantle cell lymphoma Osteoarthrosis Deformans
HA [auth T], VA [auth t]	Pharos: P28070	HIV infectious disease HIV Coinfection lymphoplasmacytic lymphoma plasma cell myeloma Sjogren syndrome major depressive disorder proteasome-associated autoinflammatory syndrome 3 lung cancer ovarian cancer psoriasis
D [auth X]	Pharos: O00231	attention deficit hyperactivity disorder, inattentive type glioblastoma malignant ependymoma osteosarcoma plasma cell myeloma atypical teratoid rhabdoid tumor lung adenocarcinoma malignant glioma ovarian cancer subependymal giant cell astrocytoma breast cancer lung cancer malignant mesothelioma Pick disease tuberculosis
E [auth Y]	Pharos: Q15008	HIV infectious disease type 2 diabetes mellitus breast carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma Diabetes Mellitus, Non-Insulin-Dependent malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm maturity-onset diabetes of the young pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
F [auth Z]	Pharos: P51665	lung cancer psoriasis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm
G [auth a]	Pharos: Q9UNM6	HIV infectious disease benign prostatic hyperplasia heart disease osteosarcoma psoriasis brain aneurysm HIV Coinfection ovarian cancer uterine corpus leiomyoma Hashimoto thyroiditis plasma cell myeloma
H [auth b]	Pharos: P55036	heart disease ovarian cancer lung cancer plasma cell myeloma myocardial infarction
I [auth c]	Pharos: O00487	breast cancer lung cancer ovarian cancer endogenous depression lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma medulloblastoma plasma cell myeloma