6N8Q

Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). Unphosphorylated, crystal form 2.

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lgl_C	e6n8qA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lgl_C	ECOD (1.6)
A	ANAPC4_WD40_6	e6n8qA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08366	LLGL2 (LLGL)	LLGL2	-	Family
A	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Lethal(2) giant larvae protein homolog 2	protein binding binding PDZ domain binding protein domain specific binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cytoskeletal protein binding myosin II binding myosin binding	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication cellular process signal transduction cellular component organization organelle organization actin cytoskeleton organization cortical actin cytoskeleton organization cortical cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization Golgi vesicle transport cell division nitrogen compound transport organic anion transport carboxylic acid transport neutral amino acid transport L-amino acid transport L-leucine transport organic cation transport organic acid transport amino acid transport branched-chain amino acid transport regulation of establishment or maintenance of cell polarity establishment or maintenance of cell polarity secretion by cell exocytosis secretion export from cell establishment of organelle localization microtubule cytoskeleton organization spindle localization establishment of cell polarity establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell microtubule-based process cell cycle cell cycle process establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity	cell-cell junction adherens junction cellular anatomical structure anchoring junction cell junction intracellular anatomical structure cell cortex cortical cytoskeleton intracellular membraneless organelle actin cytoskeleton intracellular organelle cell periphery cytoskeleton organelle cell-cell junction adherens junction cellular anatomical structure anchoring junction cell junction intracellular anatomical structure cell cortex cortical cytoskeleton intracellular membraneless organelle actin cytoskeleton intracellular organelle cell periphery cytoskeleton organelle membraneless organelle cortical actin cytoskeleton cytoplasm cytosol plasma membrane membrane membrane-bounded organelle intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000664	Lethal(2) giant larvae protein	Family
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR013577	Lethal giant larvae homologue 2	Domain
A	IPR001680	WD40 repeat	Repeat
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q6P1M3	Neoplasm Metastasis breast carcinoma breast cancer interstitial cystitis pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ductal breast carcinoma in situ malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.