6R2U

Zinc-alpha2-Glycoprotein with a Fluorescent Dansyl C 11 Fatty Acid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6r2ua2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6r2ua1	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Zinc-alpha-2-glycoprotein, ZAG	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d6r2ub2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d6r2ub1	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Zinc-alpha-2-glycoprotein, ZAG	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6r2uc2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6r2uc1	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Zinc-alpha-2-glycoprotein, ZAG	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6r2ud2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6r2ud1	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Zinc-alpha-2-glycoprotein, ZAG	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d6r2ue2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d6r2ue1	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Zinc-alpha-2-glycoprotein, ZAG	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d6r2uf2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d6r2uf1	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Zinc-alpha-2-glycoprotein, ZAG	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8042420	3000521	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054639	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MHC antigen-recognition domain	8042420	3000521	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054639	3000071	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054639	3000071	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	MHC antigen-recognition domain	8042420	3000521	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	MHC antigen-recognition domain	8042420	3000521	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054639	3000071	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054639	3000071	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	MHC antigen-recognition domain	8042420	3000521	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	MHC antigen-recognition domain	8042420	3000521	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054639	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C1-set_2	e6r2uA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
A	MHC_I	e6r2uA2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
B	C1-set_2	e6r2uB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
B	MHC_I	e6r2uB2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
C	C1-set_2	e6r2uC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
C	MHC_I	e6r2uC2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
D	C1-set_2	e6r2uD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
D	MHC_I	e6r2uD1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
E	C1-set_2	e6r2uE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
E	MHC_I	e6r2uE2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
F	C1-set_2	e6r2uF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
F	MHC_I	e6r2uF2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (utative)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
B	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (utative)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (utative)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
D	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (utative)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
E	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (utative)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
F	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (utative)
F	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B, C, D, E A, B, C, D, E, F	zinc-alpha-2-glycoprotein, ZAG)	I-ALPHA-LIKE	Homo sapiens (human)	AZGP1*01	G-DOMAIN G-ALPHA1-LIKE, G-DOMAIN G-ALPHA2-LIKE, C-LIKE-DOMAIN C-LIKE	RPI	MH1LIKE-ALPHA-LIKE[3D]	IMGT (202445-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00129	Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)	Class I Histocompatibility antigen, domains alpha 1 and 2	-	Domain
A, B, C, D, E A, B, C, D, E, F	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Zinc-alpha-2-glycoprotein	macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	response to stimulus immune response immune system process negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process cellular process cell adhesion multicellular organismal process response to stimulus immune response immune system process negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process cellular process cell adhesion multicellular organismal process system process nervous system process detection of chemical stimulus involved in sensory perception of bitter taste detection of chemical stimulus involved in sensory perception of taste detection of stimulus sensory perception of chemical stimulus sensory perception sensory perception of taste response to chemical detection of chemical stimulus sensory perception of bitter taste detection of stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular organelle intracellular anatomical structure nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR050208	Antigen-presenting and immune regulatory MHC class I-related	Family
A, B, C, D, E A, B, C, D, E, F	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR003597	Immunoglobulin C1-set	Domain
A, B, C, D, E A, B, C, D, E, F	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR011161	MHC class I-like antigen recognition-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR001039	MHC class I alpha chain, alpha1 alpha2 domains	Domain
A, B, C, D, E A, B, C, D, E, F	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P25311	sinusitis polycystic ovary syndrome adenocarcinoma tubular adenocarcinoma prostate cancer granular cell carcinoma Malignant neoplasm of lung pancreatic ductal adenocarcinoma pilocytic astrocytoma chronic obstructive pulmonary disease cystic fibrosis idiopathic pulmonary fibrosis lung benign neoplasm malignant ependymoma malignant pancreatic neoplasm sinusitis polycystic ovary syndrome adenocarcinoma tubular adenocarcinoma prostate cancer granular cell carcinoma Malignant neoplasm of lung pancreatic ductal adenocarcinoma pilocytic astrocytoma chronic obstructive pulmonary disease cystic fibrosis idiopathic pulmonary fibrosis lung benign neoplasm malignant ependymoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm psoriasis breast cancer cribriform carcinoma glioblastoma interstitial cystitis lung carcinoma malignant glioma nephrosclerosis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis breast fibroadenoma cribriform carcinoma of breast lung adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.