7AL9

human GTP cyclohydrolase I feedback regulatory protein (GFRP) in complex with phenylalanine

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8102140	3000919	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	GFRP	e7al9C1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
D	GFRP	e7al9D1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
E	GFRP	e7al9E1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
F	GFRP	e7al9F1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
J	GFRP	e7al9J1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
A	GFRP	e7al9A1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
B	GFRP	e7al9B1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
G	GFRP	e7al9G1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
H	GFRP	e7al9H1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
I	GFRP	e7al9I1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF06399	GTP cyclohydrolase I feedback regulatory protein (GFRP) (GFRP)	GTP cyclohydrolase I feedback regulatory protein (GFRP)	Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I f ...	Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP) [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	GTP cyclohydrolase 1 feedback regulatory protein	protein binding binding GTP cyclohydrolase binding enzyme binding	regulation of biosynthetic process regulation of biological process regulation of cellular process negative regulation of metabolic process biological regulation negative regulation of biological process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process metabolic process cellular process regulation of metabolic process regulation of nitric oxide biosynthetic process reactive nitrogen species metabolic process regulation of biosynthetic process regulation of biological process regulation of cellular process negative regulation of metabolic process biological regulation negative regulation of biological process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process metabolic process cellular process regulation of metabolic process regulation of nitric oxide biosynthetic process reactive nitrogen species metabolic process nitric oxide metabolic process nitric oxide biosynthetic process regulation of nitric oxide metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle pigment granule intracellular vesicle intracellular membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle vesicle nuclear membrane membrane nucleus endomembrane system organelle envelope nuclear envelope organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036717	GFRP superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR009112	GTP cyclohydrolase I, feedback regulatory protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Pharos: P30047	Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous neoplasm non-small cell lung carcinoma psoriasis pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.