Crystal structure of holo-F210W mutant of Hydroxy ketone aldolase (SwHKA) from Sphingomonas wittichii RW1, with the active site in the resting and the active state
Domain Annotation: ECOD Classification ECOD Database Homepage
| Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
|---|---|---|---|---|---|---|---|---|
| A | HpcH_HpaI | e7obuA1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: HpcH_HpaI | ECOD (1.6) |
| B | HpcH_HpaI | e7obuB1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: HpcH_HpaI | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
| Chains | Accession | Name | Description | Comments | Source |
|---|---|---|---|---|---|
| PF03328 | HpcH/HpaI aldolase/citrate lyase (HpcH_HpaI) | HpcH/HpaI aldolase/citrate lyase | This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
| Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
|---|---|---|---|---|
| HpcH/HpaI aldolase | - |
InterPro: Protein Family Classification InterPro Database Homepage
| Chains | Accession | Name | Type |
|---|---|---|---|
| IPR015813 | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily | Homologous Superfamily | |
| IPR040442 | Pyruvate kinase-like domain superfamily | Homologous Superfamily | |
| IPR050251 | HpcH/HpaI aldolase | Family | |
| IPR005000 | HpcH/HpaI aldolase/citrate lyase domain | Domain | |
| IPR015813 | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily | Homologous Superfamily | |
| IPR040442 | Pyruvate kinase-like domain superfamily | Homologous Superfamily | |
| IPR050251 | HpcH/HpaI aldolase | Family | |
| IPR005000 | HpcH/HpaI aldolase/citrate lyase domain | Domain |
