Annotations: 8CHE

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth L], D [auth B]	Light Chain	IGKV2	Kappa	trem-like transcript 1 protein	SAbDab (2024-11-15)
A [auth H], C [auth A]	Heavy Chain	IGHV3	-	trem-like transcript 1 protein	SAbDab (2024-11-15)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth L], D [auth B]	Fab light chain	-	-	-
A [auth H], C [auth A]	Fab heavy chain	-	-	-
E [auth C], F [auth D]	Trem-like transcript 1 protein	-	multicellular organismal process regulation of body fluid levels wound healing response to stimulus cell activation hemostasis biological regulation blood coagulation response to stress coagulation cellular process regulation of biological quality response to wounding platelet activation multicellular organismal process regulation of body fluid levels wound healing response to stimulus cell activation hemostasis biological regulation blood coagulation response to stress coagulation cellular process regulation of biological quality response to wounding platelet activation biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus cellular response to stimulus regulation of biological process regulation of cellular process signaling intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule vesicle cell surface cytosol cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth C], F [auth D]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
E [auth C], F [auth D]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
E [auth C], F [auth D]	IPR050671	CD300 family immune receptors	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth C], F [auth D]	Pharos: Q86YW5	juvenile idiopathic arthritis Alzheimer disease gastric carcinoma Juvenile psoriatic arthritis malignant pancreatic neoplasm psoriasis exocrine pancreatic carcinoma MALT lymphoma gastric cancer osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.