Annotations: 8D6P

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Transferrin_2nd	e8d6pA1	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: Transferrin_2nd	ECOD (1.6)
A	Transferrin_1st	e8d6pA3	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: Transferrin_1st	ECOD (1.6)
A	Transferrin_2nd,Transferrin_1st	e8d6pA2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: Transferrin_2nd,Transferrin_1st	ECOD (1.6)
A	Thyroglobulin_1	e8d6pA5	A: few secondary structure elements	X: Thyroglobulin type-1 domain (From Topology)	H: Thyroglobulin type-1 domain (From Topology)	T: Thyroglobulin type-1 domain	F: Thyroglobulin_1	ECOD (1.6)
B	Transferrin_2nd	e8d6pB1	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: Transferrin_2nd	ECOD (1.6)
B	Transferrin_1st	e8d6pB3	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: Transferrin_1st	ECOD (1.6)
B	Transferrin_2nd,Transferrin_1st	e8d6pB2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: Transferrin_2nd,Transferrin_1st	ECOD (1.6)
B	Thyroglobulin_1	e8d6pB5	A: few secondary structure elements	X: Thyroglobulin type-1 domain (From Topology)	H: Thyroglobulin type-1 domain (From Topology)	T: Thyroglobulin type-1 domain	F: Thyroglobulin_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00405	Transferrin (Transferrin)	Transferrin		Domain
A, B	PF00086	Thyroglobulin type-1 repeat (Thyroglobulin_1)	Thyroglobulin type-1 repeat	Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation [2]. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Saxiphilin	-	humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process response to bacterium response to external biotic stimulus localization transport iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle cell periphery membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle cell periphery plasma membrane membrane extracellular region extracellular space recycling endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016357	Transferrin	Family
A, B	IPR001156	Transferrin-like domain	Domain
A, B	IPR036857	Thyroglobulin type-1 superfamily	Homologous Superfamily
A, B	IPR000716	Thyroglobulin type-1	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.