Annotations: 8KDN

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF13520	Amino acid permease (AA_permease_2)	Amino acid permease	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	4F2 cell-surface antigen heavy chain	protein binding binding virus receptor activity exogenous protein binding RNA binding double-stranded RNA binding nucleic acid binding protein heterodimerization activity protein dimerization activity alanine transmembrane transporter activity L-amino acid transmembrane transporter activity organic cation transmembrane transporter activity carboxylic acid transmembrane transporter activity amino acid transmembrane transporter activity protein binding binding virus receptor activity exogenous protein binding RNA binding double-stranded RNA binding nucleic acid binding protein heterodimerization activity protein dimerization activity alanine transmembrane transporter activity L-amino acid transmembrane transporter activity organic cation transmembrane transporter activity carboxylic acid transmembrane transporter activity amino acid transmembrane transporter activity L-alanine transmembrane transporter activity neutral L-amino acid transmembrane transporter activity transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity aromatic amino acid transmembrane transporter activity identical protein binding protein homodimerization activity cell adhesion molecule binding cadherin binding L-leucine transmembrane transporter activity branched-chain amino acid transmembrane transporter activity	amino acid transport organic acid transport localization nitrogen compound transport organic anion transport carboxylic acid transport transport neutral amino acid transport proline transport establishment of localization branched-chain amino acid transport isoleucine transport aromatic amino acid transport tyrosine transport amino acid transport organic acid transport localization nitrogen compound transport organic anion transport carboxylic acid transport transport neutral amino acid transport proline transport establishment of localization branched-chain amino acid transport isoleucine transport aromatic amino acid transport tyrosine transport L-amino acid transport organic cation transport carbohydrate metabolic process primary metabolic process metabolic process cellular process phenylalanine transport biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction thyroid hormone transport regulation of hormone levels biological regulation hormone transport regulation of biological quality response to stimulus response to chemical response to dsRNA response to nitrogen compound response to exogenous dsRNA import into cell carboxylic acid transmembrane transport amino acid transmembrane transport organic acid transmembrane transport L-alanine transmembrane transport import across plasma membrane L-alanine import across plasma membrane alanine transport transmembrane transport L-alanine transport L-alpha-amino acid transmembrane transport amino acid import across plasma membrane methionine transport sulfur amino acid transport sulfur compound transport L-leucine transport L-leucine import across plasma membrane monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport valine transport L-histidine transport basic amino acid transport histidine transport tryptophan transport	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle cell periphery cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane basal part of cell basal plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell surface anchoring junction cell junction basolateral plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome somatodendritic compartment cell body cell pole apical pole of neuron neuronal cell body synapse amino acid transport complex protein-containing complex plasma membrane protein complex membrane protein complex
B	Large neutral amino acids transporter small subunit 1	binding antigen binding peptide antigen binding peptide binding antiporter activity active transmembrane transporter activity transporter activity transmembrane transporter activity secondary active transmembrane transporter activity aromatic amino acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity organic anion transmembrane transporter activity amino acid transmembrane transporter activity binding antigen binding peptide antigen binding peptide binding antiporter activity active transmembrane transporter activity transporter activity transmembrane transporter activity secondary active transmembrane transporter activity aromatic amino acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity organic anion transmembrane transporter activity amino acid transmembrane transporter activity neutral L-amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity organic cation transmembrane transporter activity L-tryptophan transmembrane transporter activity thyroid hormone transmembrane transporter activity L-leucine transmembrane transporter activity branched-chain amino acid transmembrane transporter activity	response to stimulus response to activity response to muscle activity nitrogen compound transport organic anion transport carboxylic acid transport transport neutral amino acid transport establishment of localization amino acid transport organic acid transport localization branched-chain amino acid transport isoleucine transport response to stimulus response to activity response to muscle activity nitrogen compound transport organic anion transport carboxylic acid transport transport neutral amino acid transport establishment of localization amino acid transport organic acid transport localization branched-chain amino acid transport isoleucine transport organic cation transport alanine transport cellular response to stimulus cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress cellular process response to starvation cellular response to glucose starvation cellular response to starvation thyroid hormone transport regulation of hormone levels biological regulation hormone transport regulation of biological quality transmembrane transport amino acid transmembrane transport xenobiotic transport import into cell import across plasma membrane amino acid import across plasma membrane methionine transport sulfur amino acid transport sulfur compound transport cellular response to acid chemical cellular response to nitrogen compound cellular response to amino acid stimulus response to L-arginine response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to oxygen-containing compound response to acid chemical cellular response to chemical stimulus response to chemical cellular response to L-arginine negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process autophagy negative regulation of biological process regulation of catabolic process regulation of autophagy negative regulation of autophagy negative regulation of cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process L-amino acid transport L-leucine transport valine transport multicellular organismal process system process circulatory system process vascular process in circulatory system vascular transport transport across blood-brain barrier aromatic amino acid transport tryptophan transport proline transport tyrosine transport phenylalanine transport organic acid transmembrane transport carboxylic acid transmembrane transport L-tryptophan transmembrane transport L-alpha-amino acid transmembrane transport regulation of localization positive regulation of biological process positive regulation of amine transport positive regulation of transmembrane transport regulation of amino acid transport regulation of amino acid transmembrane transport positive regulation of cellular process regulation of L-leucine import across plasma membrane regulation of transport positive regulation of organic acid transport amine transport regulation of amino acid import across plasma membrane regulation of transmembrane transport positive regulation of transport positive regulation of amino acid transport regulation of organic acid transport L-leucine import across plasma membrane regulation of amine transport positive regulation of L-leucine import across plasma membrane biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide response to biotic stimulus cellular response to biotic stimulus response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin developmental process gland development animal organ development animal organ regeneration liver development regeneration multicellular organism development hepaticobiliary system development anatomical structure development liver regeneration system development muscle cell apoptotic process smooth muscle cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process negative regulation of vascular associated smooth muscle cell apoptotic process vascular associated smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process negative regulation of apoptotic process negative regulation of muscle cell apoptotic process regulation of vascular associated smooth muscle cell apoptotic process apoptotic process programmed cell death positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process interleukin-17 production regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression regulation of interleukin-17 production biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of interleukin-17 production macromolecule metabolic process positive regulation of cytokine production L-histidine transport basic amino acid transport histidine transport negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process positive regulation of nervous system development cellular developmental process regulation of developmental process positive regulation of cell population proliferation cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process neurogenesis regulation of glial cell proliferation gliogenesis positive regulation of cell differentiation cell differentiation positive regulation of neurogenesis regulation of multicellular organismal development cell population proliferation positive regulation of cell development nervous system development regulation of cell population proliferation glial cell proliferation regulation of interleukin-4 production positive regulation of interleukin-4 production interleukin-4 production regulation of immune effector process positive regulation of immune effector process regulation of immune system process cytokine production involved in immune response positive regulation of immune system process production of molecular mediator of immune response regulation of cytokine production involved in immune response immune response immune effector process immune system process positive regulation of cytokine production involved in immune response positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response regulation of type II interferon production type II interferon production positive regulation of type II interferon production response to oxygen levels response to abiotic stimulus response to hyperoxia response to increased oxygen levels	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol plasma membrane plasma membrane bounded cell projection cell periphery cell projection actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane basal part of cell basal plasma membrane basolateral plasma membrane vacuolar membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome apical part of cell apical plasma membrane external side of apical plasma membrane side of membrane cell surface external side of plasma membrane amino acid transport complex protein-containing complex plasma membrane protein complex membrane protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily
A	IPR042280	Amino acid transporter heavy chain SLC3A2	Family
A	IPR031984	Solute carrier family 3 member 2, N-terminal domain	Domain
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR006047	Glycosyl hydrolase, family 13, catalytic domain	Domain
B	IPR004760	L-type amino acid transporter	Family
B	IPR002293	Amino acid/polyamine transporter I	Family
B	IPR050598	Cellular Amino Acid Transporter	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08195	breast cancer Lung Neoplasms polycystic ovary syndrome diabetes mellitus malignant ependymoma tuberculosis lung benign neoplasm
B	Pharos: Q01650	allergic contact dermatitis polycystic ovary syndrome Sjogren syndrome breast carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant mesothelioma osteosarcoma psoriasis tuberculosis atopic eczema congestive heart failure Gaucher disease lung adenocarcinoma allergic contact dermatitis polycystic ovary syndrome Sjogren syndrome breast carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant mesothelioma osteosarcoma psoriasis tuberculosis atopic eczema congestive heart failure Gaucher disease lung adenocarcinoma Lung Neoplasms ovarian cancer retinal disease ulcerative colitis breast cancer cystic fibrosis IgA glomerulonephritis lung benign neoplasm malignant colon neoplasm non-small cell lung carcinoma

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.