8QL1 | pdb_00008ql1

Crystal structure of the human MDN1-MIDAS/NLE1-UBL complex

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D, F, H	PF08154	NLE (NUC135) domain (NLE)	NLE (NUC135) domain	This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	NDE1	-	-	-
B, D, F, H	Notchless protein homolog 1	-	cellular process cell cycle mitotic cell cycle cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell communication Notch signaling pathway cellular process cell cycle mitotic cell cycle cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication signal transduction cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal large subunit biogenesis somitogenesis developmental process multicellular organismal process epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization multicellular organism development anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure development anatomical structure formation involved in morphogenesis multicellular organismal-level homeostasis homeostatic process hematopoietic stem cell homeostasis homeostasis of number of cells skeletal system development animal organ development skeletal system morphogenesis animal organ morphogenesis system development cellular developmental process inner cell mass cell differentiation in utero embryonic development blastocyst formation cell differentiation blastocyst development positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of biological process positive regulation of response to stimulus positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of cellular process positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway positive regulation of signaling kidney development renal system development negative regulation of biological process negative regulation of cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process regulation of cell cycle	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D, F, H	IPR019775	WD40 repeat, conserved site	Conserved Site
B, D, F, H	IPR012972	NLE	Domain
B, D, F, H	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B, D, F, H	IPR001632	G-protein, beta subunit	Domain
B, D, F, H	IPR001680	WD40 repeat	Repeat
B, D, F, H	IPR020472	G-protein beta WD-40 repeat	Repeat
B, D, F, H	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D, F, H	Pharos: Q9NVX2	large cell medulloblastoma Malignant neoplasm of breast pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia malignant colon neoplasm pancreatic intraductal papillary-mucinous carcinoma malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.