8QYZ | pdb_00008qyz

Crystal structure of hiNES2 in complex with Xpo1 and RanGTP

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8057452	3002022	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Ras-like P-loop GTPases	8057452	3002022	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ras-like P-loop GTPases	8057452	3002022	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ras-like P-loop GTPases	8057452	3002022	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E, G	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motili ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain
B [auth C], D, F, H	PF08389	Exportin 1-like protein (Xpo1)	Exportin 1-like protein	-	Repeat
B [auth C], D, F, H	PF18784	CRM1 / Exportin repeat 2 (CRM1_repeat_2)	CRM1 / Exportin repeat 2	-	Repeat
B [auth C], D, F, H	PF18777	Chromosome region maintenance or exportin repeat (CRM1_repeat)	Chromosome region maintenance or exportin repeat	-	Repeat
B [auth C], D, F, H	PF18787	CRM1 / Exportin repeat 3 (CRM1_repeat_3)	CRM1 / Exportin repeat 3	-	Repeat
B [auth C], D, F, H	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat
B [auth C], D, F, H	PF08767	CRM1 C terminal (CRM1_C)	CRM1 C terminal	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E, G	GTP-binding nuclear protein GSP1/CNR1	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process regulation of biological process regulation of cell cycle phase transition regulation of cellular process regulation of cell cycle process biological regulation cell cycle phase transition cell cycle regulation of cell cycle cell cycle process establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus protein-containing complex localization cellular component biogenesis ribosome biogenesis organelle localization cellular component organization or biogenesis ribosome localization cellular component organization nucleus organization organelle organization exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA metabolic process rRNA processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA 3'-end processing RNA processing rRNA metabolic process maturation of 5.8S rRNA primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA 3'-end processing regulation of localization regulation of transport regulation of nucleocytoplasmic transport regulation of cellular localization regulation of intracellular transport protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B [auth C], D, F, H	Exportin-1	small GTPase binding protein binding binding enzyme binding GTPase binding RNA binding snRNA binding nucleic acid binding U1 snRNA binding U6 snRNA binding U4 snRNA binding nucleocytoplasmic carrier activity nuclear export signal receptor activity molecular carrier activity small GTPase binding protein binding binding enzyme binding GTPase binding RNA binding snRNA binding nucleic acid binding U1 snRNA binding U6 snRNA binding U4 snRNA binding nucleocytoplasmic carrier activity nuclear export signal receptor activity molecular carrier activity U5 snRNA binding nuclear import signal receptor activity U2 snRNA binding	cellular localization RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport tRNA export from nucleus establishment of localization RNA export from nucleus localization tRNA re-export from nucleus tRNA transport establishment of RNA localization cellular localization RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport tRNA export from nucleus establishment of localization RNA export from nucleus localization tRNA re-export from nucleus tRNA transport establishment of RNA localization establishment of localization in cell macromolecule localization cellular process RNA localization nuclear export nucleobase-containing compound transport establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus protein-containing complex localization cellular component biogenesis ribosome biogenesis ribosomal small subunit export from nucleus organelle localization cellular component organization or biogenesis ribosome localization protein localization establishment of protein localization protein export from nucleus protein transport cellular macromolecule localization intracellular protein transport protein localization to chromosome, centromeric region protein localization to kinetochore protein localization to chromosome protein localization to condensed chromosome protein localization to organelle mRNA transport mRNA export from nucleus gene expression macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process ribosomal large subunit export from nucleus	cellular anatomical structure intracellular anatomical structure cytoplasm intracellular membraneless organelle chromosome chromosomal region kinetochore intracellular organelle organelle membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cellular anatomical structure intracellular anatomical structure cytoplasm intracellular membraneless organelle chromosome chromosomal region kinetochore intracellular organelle organelle membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome microtubule organizing center cytoskeleton spindle pole body microtubule cytoskeleton perinuclear region of cytoplasm membrane-bounded organelle nucleus intracellular membrane-bounded organelle
I, J, K, L	hiNES2	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E, G	IPR005225	Small GTP-binding domain	Domain
A, C [auth B], E, G	IPR001806	Small GTPase	Family
A, C [auth B], E, G	IPR002041	Ran GTPase	Family
A, C [auth B], E, G	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth C], D, F, H	IPR041123	Chromosome region maintenance repeat	Repeat
B [auth C], D, F, H	IPR016024	Armadillo-type fold	Homologous Superfamily
B [auth C], D, F, H	IPR041235	Exportin-1, repeat 2	Repeat
B [auth C], D, F, H	IPR001494	Importin-beta, N-terminal domain	Domain
B [auth C], D, F, H	IPR011989	Armadillo-like helical	Homologous Superfamily
B [auth C], D, F, H	IPR045065	Exportin-1/5	Family
B [auth C], D, F, H	IPR013598	Exportin-1/Importin-beta-like	Domain
B [auth C], D, F, H	IPR014877	Exportin-1, C-terminal	Domain
B [auth C], D, F, H	IPR040485	Exportin-1, repeat 3	Repeat

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.