8RIU | pdb_00008riu

Crystal structure of the F420-reducing carbon monoxide dehydrogenase component from the ethanotroph Candidatus Ethanoperedens thermophilum

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF03063	Prismane/CO dehydrogenase family (Prismane)	Prismane/CO dehydrogenase family	-	Family
B, E	PF04422	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term (FrhB_FdhB_N)	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	Family
B, E	PF04432	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus (FrhB_FdhB_C)	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus	Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits [1], [2]. The N terminus of Methanobacterium formicicum fo ...	Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits [1], [2]. The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family [3]. This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037).	Domain
C, F	PF02552	CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit (CO_dh)	CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Acetyl-CoA decarbonylase/synthase complex subunit alpha	cation binding transition metal ion binding ion binding binding nickel cation binding metal ion binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity iron ion binding anaerobic carbon-monoxide dehydrogenase activity cation binding transition metal ion binding ion binding binding nickel cation binding metal ion binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity iron ion binding anaerobic carbon-monoxide dehydrogenase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors hydroxylamine reductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding	nucleoside phosphate metabolic process primary metabolic process acetyl-CoA metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process sulfur compound metabolic process small molecule metabolic process amide metabolic process nucleoside phosphate metabolic process primary metabolic process acetyl-CoA metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process sulfur compound metabolic process small molecule metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process generation of precursor metabolites and energy response to hydrogen peroxide response to oxidative stress response to stimulus response to stress response to chemical response to oxygen-containing compound response to reactive oxygen species	-
B, E	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity cation binding ion binding iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity cation binding ion binding metal ion binding	-	-
C, F	Acetyl-CoA decarbonylase/synthase complex subunit epsilon	-	cellular respiration oxoacid metabolic process energy derivation by oxidation of organic compounds carboxylic acid metabolic process alkane biosynthetic process acetate metabolic process methane metabolic process organic acid metabolic process generation of precursor metabolites and energy hydrocarbon metabolic process alkane metabolic process biosynthetic process energy derivation by oxidation of reduced inorganic compounds methanogenesis cellular respiration oxoacid metabolic process energy derivation by oxidation of organic compounds carboxylic acid metabolic process alkane biosynthetic process acetate metabolic process methane metabolic process organic acid metabolic process generation of precursor metabolites and energy hydrocarbon metabolic process alkane metabolic process biosynthetic process energy derivation by oxidation of reduced inorganic compounds methanogenesis small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process hydrocarbon biosynthetic process anaerobic respiration methanogenesis, from acetate	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR016099	Prismane-like, alpha/beta-sandwich	Homologous Superfamily
A, D	IPR004137	Hydroxylamine reductase/Ni-containing CO dehydrogenase	Family
A, D	IPR016101	CO dehydrogenase, alpha-bundle	Homologous Superfamily
A, D	IPR004460	Acetyl-CoA decarbonylase/synthase complex subunit alpha	Family
A, D	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
A, D	IPR011254	Prismane-like superfamily	Homologous Superfamily
B, E	IPR045220	Oxidoreductase FRHB/FDHB/HCAR-like	Family
B, E	IPR007516	Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal	Domain
B, E	IPR007525	Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal	Domain
C, F	IPR003704	Acetyl-CoA decarbonylase/synthase complex subunit epsilon	Family
C, F	IPR029035	DHS-like NAD/FAD-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.