8VI1 | pdb_00008vi1

Crystal structure of c-Met-D1228N in complex with KIN-7615

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Hepatocyte growth factor receptor	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity GPI-linked ephrin receptor activity protein-hormone receptor activity insulin receptor activity histone H3Y41 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity placental growth factor receptor activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity brain-derived neurotrophic factor receptor activity neurotrophin receptor activity insulin-like growth factor receptor activity hepatocyte growth factor receptor activity identical protein binding boss receptor activity epidermal growth factor receptor activity macrophage colony-stimulating factor receptor activity platelet-derived growth factor alpha-receptor activity semaphorin receptor activity fibroblast growth factor receptor activity molecular function activator activity molecular function regulator activity vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone H2AX kinase activity	developmental process multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure anatomical structure development epithelial tube morphogenesis developmental process multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure anatomical structure development epithelial tube morphogenesis morphogenesis of a branching epithelium localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport establishment of skin barrier skin development skin epidermis development epidermis development animal organ development regulation of hydrogen peroxide-mediated programmed cell death cellular response to stimulus regulation of cellular process response to stimulus programmed cell death in response to reactive oxygen species cellular response to oxidative stress negative regulation of biological process regulation of programmed cell death cellular response to chemical stress negative regulation of hydrogen peroxide-mediated programmed cell death cellular response to reactive oxygen species hydrogen peroxide-mediated programmed cell death cellular response to stress response to stress negative regulation of cellular process regulation of biological process negative regulation of programmed cell death biological regulation response to oxygen-containing compound cell death cellular response to oxygen-containing compound response to reactive oxygen species response to oxidative stress cellular response to chemical stimulus response to chemical programmed cell death negative regulation of thrombin-activated receptor signaling pathway signaling negative regulation of signaling regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cell communication thrombin-activated receptor signaling pathway signal transduction regulation of G protein-coupled receptor signaling pathway regulation of signaling negative regulation of response to stimulus regulation of thrombin-activated receptor signaling pathway negative regulation of signal transduction regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway positive chemotaxis chemotaxis taxis response to external stimulus locomotion cell migration cell motility nervous system development system development negative regulation of catabolic process catabolic process negative regulation of metabolic process autophagy regulation of catabolic process regulation of autophagy negative regulation of autophagy metabolic process process utilizing autophagic mechanism regulation of metabolic process positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization positive regulation of cellular component organization microtubule cytoskeleton organization positive regulation of biological process cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization positive regulation of protein polymerization protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process protein polymerization positive regulation of microtubule polymerization or depolymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of microtubule-based process microtubule polymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization organelle organization positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of catalytic activity regulation of binding negative regulation of molecular function regulation of GTPase activity positive regulation of binding positive regulation of molecular function regulation of molecular function regulation of hydrolase activity negative regulation of guanyl-nucleotide exchange factor activity regulation of guanyl-nucleotide exchange factor activity hepaticobiliary system development gland development liver development endothelial cell differentiation cellular developmental process endothelium development cell development epithelial cell differentiation cell morphogenesis endothelial cell development epithelial cell development endothelial cell morphogenesis epithelial cell morphogenesis cell differentiation regulation of actin filament-based process regulation of actin filament bundle assembly actin filament bundle organization actin filament-based process stress fiber assembly negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of stress fiber assembly actin cytoskeleton organization actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization actin filament organization negative regulation of actin filament bundle assembly regulation of stress fiber assembly negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization regulation of actin cytoskeleton organization actin filament bundle assembly generation of neurons neurogenesis neuron differentiation regulation of postsynaptic membrane potential system process chemical synaptic transmission, postsynaptic synaptic signaling regulation of biological quality trans-synaptic signaling cell surface receptor signaling pathway nervous system process cell-cell signaling chemical synaptic transmission anterograde trans-synaptic signaling excitatory postsynaptic potential regulation of membrane potential pancreas development positive regulation of locomotion regulation of cell motility regulation of response to external stimulus endothelial cell migration positive regulation of chemotaxis positive regulation of cell migration positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration positive regulation of endothelial cell chemotaxis regulation of endothelial cell migration endothelial cell chemotaxis cell chemotaxis regulation of endothelial cell chemotaxis regulation of chemotaxis regulation of locomotion positive regulation of endothelial cell migration small GTPase-mediated signal transduction negative regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction negative regulation of intracellular signal transduction intracellular signal transduction Rho protein signal transduction regulation of intracellular signal transduction intracellular signaling cassette negative regulation of small GTPase mediated signal transduction regulation of Rho protein signal transduction semaphorin-plexin signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway	cellular anatomical structure membrane protein-containing complex receptor complex postsynapse synapse cell junction cell periphery basal part of cell plasma membrane basal plasma membrane plasma membrane region cell surface extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002909	IPT domain	Domain
A, B	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR016244	Tyrosine-protein kinase, HGF/MSP receptor	Family
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B	IPR031148	Plexin family	Family
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR036352	Sema domain superfamily	Homologous Superfamily
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR016201	PSI domain	Domain
A, B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, B	IPR002165	Plexin repeat	Repeat
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR001627	Sema domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P08581	squamous cell carcinoma hepatocellular carcinoma glioblastoma renal cell carcinoma neuroblastoma osteosarcoma papillary renal cell carcinoma acute myeloid leukemia non-small cell lung carcinoma osteofibrous dysplasia ovarian cancer cancer nonsyndromic genetic deafness esophageal cancer autosomal recessive nonsyndromic deafness 97 squamous cell carcinoma hepatocellular carcinoma glioblastoma renal cell carcinoma neuroblastoma osteosarcoma papillary renal cell carcinoma acute myeloid leukemia non-small cell lung carcinoma osteofibrous dysplasia ovarian cancer cancer nonsyndromic genetic deafness esophageal cancer autosomal recessive nonsyndromic deafness 97 giant cell glioblastoma granular cell carcinoma sarcomatoid renal cell carcinoma Hepatitis, Chronic adenocarcinoma juvenile pilocytic astrocytoma lung cancer fibrillary astrocytoma protoplasmic astrocytoma schizophrenia collecting duct carcinoma astrocytic tumor pilocytic astrocytoma gastric cancer prostate cancer gemistocytic astrocytoma sarcomatoid carcinoma carcinoma sinusitis childhood cerebral astrocytoma chromophobe renal cell carcinoma subependymal giant cell astrocytoma tubular adenocarcinoma anaplastic astrocytoma malignant mesothelioma benign neoplasm of stomach renal carcinoma malignant pancreatic neoplasm breast disease hereditary diffuse gastric adenocarcinoma interstitial lung disease adrenal medulla cancer cribriform carcinoma of breast pancreatic intraductal papillary-mucinous neoplasm esophageal adenocarcinoma attention deficit hyperactivity disorder, inattentive type primitive neuroectodermal tumor gastric neoplasm benign neoplasm of adrenal gland breast cancer head and neck squamous cell carcinoma medullary thyroid gland carcinoma hepatoblastoma cerebral astrocytoma cholangiocarcinoma stomach carcinoma in situ tuberculosis hereditary papillary renal cell carcinoma ulcerative colitis large cell medulloblastoma ovarian neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia lung carcinoma atypical teratoid rhabdoid tumor malignant colon neoplasm psoriasis breast carcinoma hepatitis medulloblastoma neoplasm of esophagus clear cell renal carcinoma intellectual disability non-alcoholic fatty liver disease colorectal adenocarcinoma undifferentiated carcinoma invasive ductal breast carcinoma oligodendroglioma cribriform carcinoma liver cancer pancreatic intraductal papillary-mucinous carcinoma diffuse astrocytoma lung benign neoplasm astrocytoma (excluding glioblastoma) lung disease autism pituitary cancer gastric carcinoma Barrett esophagus

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.