Annotations: 8W49

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Isocitrate/Isopropylmalate dehydrogenase-like	8067340	3001375	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Isocitrate/Isopropylmalate dehydrogenase-like	8067340	3001375	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Isocitrate/Isopropylmalate dehydrogenase-like	8067340	3001375	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Isocitrate/Isopropylmalate dehydrogenase-like	8067340	3001375	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00180	Isocitrate/isopropylmalate dehydrogenase (Iso_dh)	Isocitrate/isopropylmalate dehydrogenase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Isocitrate dehydrogenase [NADP] cytoplasmic	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding identical protein binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding identical protein binding protein binding protein homodimerization activity protein dimerization activity isocitrate dehydrogenase [NAD(P)+] activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor isocitrate dehydrogenase (NADP+) activity oxidoreductase activity, acting on CH-OH group of donors catalytic activity NAD binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy carbohydrate metabolic process glyoxylate metabolic process glyoxylate cycle oxoacid metabolic process carboxylic acid metabolic process organic acid metabolic process aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds metabolic process cellular process primary metabolic process generation of precursor metabolites and energy carbohydrate metabolic process glyoxylate metabolic process glyoxylate cycle oxoacid metabolic process carboxylic acid metabolic process organic acid metabolic process aldehyde metabolic process small molecule metabolic process monocarboxylic acid metabolic process isocitrate metabolic process tricarboxylic acid metabolic process organic hydroxy compound metabolic process alcohol metabolic process secondary alcohol metabolic process response to lipid response to stimulus response to hormone response to steroid hormone response to chemical response to endogenous stimulus response to organic cyclic compound regulation of cellular process regulation of lipid metabolic process lipid biosynthetic process regulation of primary metabolic process phospholipid metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process regulation of biosynthetic process regulation of biological process biological regulation regulation of phospholipid metabolic process phospholipid biosynthetic process regulation of phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process regulation of phosphorus metabolic process regulation of lipid biosynthetic process regulation of metabolic process lipid metabolic process response to oxidative stress response to stress 2-oxoglutarate metabolic process dicarboxylic acid metabolic process catabolic process phospholipid catabolic process organophosphate catabolic process regulation of phospholipid catabolic process lipid catabolic process regulation of catabolic process regulation of lipid catabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process nucleotide metabolic process purine-containing compound metabolic process NADP metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process pyridine-containing compound metabolic process pyridine nucleotide metabolic process glutathione metabolic process modified amino acid metabolic process sulfur compound metabolic process amide metabolic process developmental process multicellular organismal process gonad development reproductive system development reproductive process female gonad development sex differentiation animal organ development female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction multicellular organism development development of primary sexual characteristics anatomical structure development reproductive structure development system development	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle peroxisome microbody cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR004790	Isocitrate dehydrogenase NADP-dependent	Family
A, B, C, D	IPR024084	Isopropylmalate dehydrogenase-like domain	Domain
A, B, C, D	IPR019818	Isocitrate/isopropylmalate dehydrogenase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.