Annotations: 8XUM

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	MB52	-	-	-
B [auth A]	Leucine-rich repeat-containing G-protein coupled receptor 4	molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity peptide receptor activity G protein-coupled peptide receptor activity protein-hormone receptor activity	multicellular organismal process tissue remodeling bone remodeling developmental process epithelium development cell population proliferation tube development morphogenesis of an epithelium tissue development renal system development epithelial cell proliferation involved in renal tubule morphogenesis tissue morphogenesis anatomical structure morphogenesis multicellular organism development multicellular organismal process tissue remodeling bone remodeling developmental process epithelium development cell population proliferation tube development morphogenesis of an epithelium tissue development renal system development epithelial cell proliferation involved in renal tubule morphogenesis tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure development renal tubule development cellular process epithelial tube morphogenesis epithelial cell proliferation renal tubule morphogenesis system development cellular developmental process ossification cell differentiation osteoblast differentiation cellular response to stimulus positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway response to stimulus toll-like receptor signaling pathway negative regulation of biological process regulation of signal transduction response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process immune response response to other organism regulation of innate immune response response to external stimulus regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response regulation of toll-like receptor signaling pathway activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus signaling negative regulation of signaling positive regulation of biological process negative regulation of cell communication positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response negative regulation of cellular process response to external biotic stimulus regulation of signaling positive regulation of innate immune response defense response negative regulation of response to stimulus biological regulation defense response to symbiont negative regulation of signal transduction negative regulation of toll-like receptor signaling pathway negative regulation of immune system process immune system process regulation of cell communication spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation bone mineralization animal organ development biomineral tissue development mesonephric epithelium development kidney epithelium development branching morphogenesis of an epithelial tube nephron tubule morphogenesis regulation of kidney development regulation of branching involved in ureteric bud morphogenesis positive regulation of developmental process animal organ morphogenesis nephron development regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis positive regulation of multicellular organismal process mesonephric tubule development regulation of developmental process nephron morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis positive regulation of morphogenesis of an epithelium branching involved in ureteric bud morphogenesis regulation of morphogenesis of an epithelium regulation of multicellular organismal process regulation of anatomical structure morphogenesis nephron epithelium development ureteric bud development mesonephros development kidney morphogenesis morphogenesis of a branching structure positive regulation of branching involved in ureteric bud morphogenesis mesonephric tubule morphogenesis kidney development morphogenesis of a branching epithelium digestive system development digestive tract development epidermis development molting cycle process hair cycle skin development skin epidermis development hair follicle development molting cycle hair cycle process genitalia development reproductive system development sex differentiation male sex differentiation male genitalia development reproductive structure development multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells intestinal stem cell homeostasis regulation of biosynthetic process rhythmic process circadian regulation of gene expression circadian rhythm regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cytokine production regulation of cytokine production negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process metanephric tubule morphogenesis metanephric epithelium development metanephros development metanephros morphogenesis metanephric nephron tubule morphogenesis metanephric nephron development metanephric nephron epithelium development metanephric nephron tubule development metanephric nephron morphogenesis metanephric tubule development cell surface receptor signaling pathway Wnt signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway positive regulation of cellular process positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway positive regulation of signaling negative regulation of cold-induced thermogenesis adaptive thermogenesis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis metanephric glomerulus development glomerulus development	cell periphery cellular anatomical structure plasma membrane membrane
C [auth B]	R-spondin-2	protein binding binding signaling receptor binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	developmental process multicellular organismal process regulation of biological process regulation of animal organ morphogenesis regulation of developmental process regulation of odontogenesis of dentin-containing tooth negative regulation of developmental process regulation of odontogenesis odontogenesis of dentin-containing tooth odontogenesis animal organ development biological regulation negative regulation of biological process negative regulation of odontogenesis anatomical structure morphogenesis developmental process multicellular organismal process regulation of biological process regulation of animal organ morphogenesis regulation of developmental process regulation of odontogenesis of dentin-containing tooth negative regulation of developmental process regulation of odontogenesis odontogenesis of dentin-containing tooth odontogenesis animal organ development biological regulation negative regulation of biological process negative regulation of odontogenesis anatomical structure morphogenesis negative regulation of odontogenesis of dentin-containing tooth anatomical structure development animal organ morphogenesis negative regulation of animal organ morphogenesis regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of anatomical structure morphogenesis cellular developmental process ossification cell differentiation cellular process osteoblast differentiation lung growth developmental growth tube development growth respiratory tube development organ growth multicellular organism development lung development respiratory system development system development trachea cartilage morphogenesis connective tissue development trachea cartilage development trachea morphogenesis tissue development tissue morphogenesis skeletal system development trachea development cartilage morphogenesis cartilage development limb development appendage development cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling embryonic forelimb morphogenesis embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development forelimb morphogenesis appendage morphogenesis limb morphogenesis bone mineralization biomineral tissue development canonical Wnt signaling pathway branching morphogenesis of an epithelial tube tube morphogenesis lung morphogenesis epithelial tube morphogenesis epithelium development morphogenesis of an epithelium morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway dopaminergic neuron differentiation nervous system development generation of neurons neurogenesis neuron differentiation embryonic hindlimb morphogenesis hindlimb morphogenesis	cellular anatomical structure extracellular region cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth A]	IPR000372	Leucine-rich repeat N-terminal domain	Domain
B [auth A]	IPR003591	Leucine-rich repeat, typical subtype	Repeat
B [auth A]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
B [auth A]	IPR002131	Glycoprotein hormone receptor family	Family
B [auth A]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
B [auth A]	IPR001611	Leucine-rich repeat	Repeat
B [auth A]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
C [auth B]	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
C [auth B]	IPR043601	R-spondin, Fu-CRD domain	Domain
C [auth B]	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
C [auth B]	IPR051514	R-spondin domain-containing protein	Family
C [auth B]	IPR006212	Furin-like repeat	Repeat
C [auth B]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth A]	Pharos: Q9BXB1	BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 17 adenoma glioblastoma lung adenocarcinoma malignant glioma obesity disorder psoriasis adrenal cortex carcinoma breast cancer interstitial cystitis lung cancer malignant mesothelioma osteoporosis spina bifida atypical teratoid rhabdoid tumor BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 17 adenoma glioblastoma lung adenocarcinoma malignant glioma obesity disorder psoriasis adrenal cortex carcinoma breast cancer interstitial cystitis lung cancer malignant mesothelioma osteoporosis spina bifida atypical teratoid rhabdoid tumor breast carcinoma large cell medulloblastoma lung carcinoma non-small cell lung carcinoma osteosarcoma
C [auth B]	Pharos: Q6UXX9	androgenetic alopecia humerofemoral hypoplasia with radiotibial ray deficiency malignant ependymoma oligodendroglioma pilocytic astrocytoma astrocytic tumor large cell medulloblastoma malignant glioma ossification of the posterior longitudinal ligament of the spine primitive neuroectodermal tumor glioblastoma lung adenocarcinoma medulloblastoma Pick disease tetraamelia syndrome 2

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.