Annotations: 8Y8N

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00230	Major intrinsic protein (MIP)	Major intrinsic protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Aquaporin-3	glycerol channel activity passive transmembrane transporter activity channel activity glycerol transmembrane transporter activity transporter activity polyol transmembrane transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity water transmembrane transporter activity inorganic molecular entity transmembrane transporter activity water channel activity identical protein binding protein binding binding	regulation of biological process immune system process biological regulation positive regulation of biological process regulation of immune system process positive regulation of immune system process transmembrane transport glycerol transmembrane transport localization transport polyol transmembrane transport carbohydrate transport cellular process organic hydroxy compound transport regulation of biological process immune system process biological regulation positive regulation of biological process regulation of immune system process positive regulation of immune system process transmembrane transport glycerol transmembrane transport localization transport polyol transmembrane transport carbohydrate transport cellular process organic hydroxy compound transport establishment of localization carbohydrate transmembrane transport developmental process anatomical structure morphogenesis odontogenesis anatomical structure development animal organ development animal organ morphogenesis multicellular organismal process regulation of body fluid levels renal system process system process homeostatic process fluid transport water transport renal water transport multicellular organismal-level homeostasis chemical homeostasis renal absorption multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis renal water absorption renal water homeostasis regulation of biological quality response to stimulus response to stress response to ischemia response to decreased oxygen levels cellular response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus response to retinoic acid response to lipid response to oxygen-containing compound cellular localization establishment of localization in cell one-carbon compound transport nitrogen compound transport amide transport urea transport	cell-cell junction cellular anatomical structure anchoring junction cell junction cell periphery plasma membrane membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022357	Major intrinsic protein, conserved site	Conserved Site
A	IPR023275	Aquaporin 3	Family
A	IPR050363	Major Intrinsic Protein/Aquaporin	Family
A	IPR023271	Aquaporin-like	Homologous Superfamily
A	IPR000425	Major intrinsic protein	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.