8YPY | pdb_00008ypy

Crystal strcuture of human phosphoribosyl pyrophosphate synthetase2 (PRPS2) in complex with ligands

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF14572	Phosphoribosyl synthetase-associated domain (Pribosyl_synth)	Phosphoribosyl synthetase-associated domain	This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.	Domain
A, B, C, D, E A, B, C, D, E, F	PF13793	N-terminal domain of ribose phosphate pyrophosphokinase (Pribosyltran_N)	N-terminal domain of ribose phosphate pyrophosphokinase	This family is frequently found N-terminal to the Pribosyltran, Pfam:PF00156.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Isoform 2 of Ribose-phosphate pyrophosphokinase 2	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein homodimerization activity protein dimerization activity ribose phosphate diphosphokinase activity diphosphotransferase activity	nucleobase-containing compound metabolic process primary metabolic process metabolic process cellular process nucleoside phosphate metabolic process nucleotide biosynthetic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process purine nucleotide metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process nucleobase-containing compound metabolic process primary metabolic process metabolic process cellular process nucleoside phosphate metabolic process nucleotide biosynthetic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process purine nucleotide metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process purine-containing compound biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process small molecule metabolic process phosphorus metabolic process purine nucleotide biosynthetic process nucleoside monophosphate biosynthetic process ribonucleoside monophosphate metabolic process ribonucleoside monophosphate biosynthetic process nucleoside monophosphate metabolic process 5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate metabolic process carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process 5-phosphoribose 1-diphosphate metabolic process ribose phosphate biosynthetic process nicotinamide nucleotide metabolic process generation of precursor metabolites and energy glucose 6-phosphate metabolic process NADP metabolic process NADPH regeneration pentose-phosphate shunt pyridine-containing compound metabolic process pyridine nucleotide metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR000842	Phosphoribosyl pyrophosphate synthetase, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR000836	Phosphoribosyltransferase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR037515	Ribose-phosphate pyrophosphokinase, bacterial-type	Family
A, B, C, D, E A, B, C, D, E, F	IPR029057	Phosphoribosyltransferase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR029099	Ribose-phosphate pyrophosphokinase, N-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR005946	Ribose-phosphate pyrophosphokinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P11908	adrenal cortex adenoma atypical teratoid rhabdoid tumor lymphoplasmacytic lymphoma oligodendroglioma plasma cell myeloma tuberculosis adrenal cortex carcinoma glioblastoma malignant ependymoma osteosarcoma polycystic ovary syndrome astrocytic tumor large cell medulloblastoma medulloblastoma ovarian cancer adrenal cortex adenoma atypical teratoid rhabdoid tumor lymphoplasmacytic lymphoma oligodendroglioma plasma cell myeloma tuberculosis adrenal cortex carcinoma glioblastoma malignant ependymoma osteosarcoma polycystic ovary syndrome astrocytic tumor large cell medulloblastoma medulloblastoma ovarian cancer primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.