8YPZ | pdb_00008ypz

Crystal strcture of human phosphoribosyl pyrophosphate synthetase 1 (PRPS1) in complex with GDP

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF13793	N-terminal domain of ribose phosphate pyrophosphokinase (Pribosyltran_N)	N-terminal domain of ribose phosphate pyrophosphokinase	This family is frequently found N-terminal to the Pribosyltran, Pfam:PF00156.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Ribose-phosphate pyrophosphokinase 1	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein homodimerization activity protein dimerization activity ribose phosphate diphosphokinase activity diphosphotransferase activity	nucleoside phosphate metabolic process nucleotide biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process purine-containing compound biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process nucleoside phosphate metabolic process nucleotide biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process purine-containing compound biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process purine nucleotide biosynthetic process pyrimidine-containing compound metabolic process pyrimidine nucleotide metabolic process pyrimidine-containing compound biosynthetic process pyrimidine nucleotide biosynthetic process nucleoside monophosphate biosynthetic process ribonucleoside monophosphate metabolic process ribonucleoside monophosphate biosynthetic process nucleoside monophosphate metabolic process 5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate metabolic process carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process 5-phosphoribose 1-diphosphate metabolic process ribose phosphate biosynthetic process developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development purine nucleobase metabolic process nucleobase metabolic process urate biosynthetic process small molecule biosynthetic process urate metabolic process nucleobase biosynthetic process purine nucleobase biosynthetic process hypoxanthine biosynthetic process hypoxanthine metabolic process	ribose phosphate diphosphokinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR000842	Phosphoribosyl pyrophosphate synthetase, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR000836	Phosphoribosyltransferase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR037515	Ribose-phosphate pyrophosphokinase, bacterial-type	Family
A, B, C, D, E A, B, C, D, E, F	IPR029057	Phosphoribosyltransferase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR029099	Ribose-phosphate pyrophosphokinase, N-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR005946	Ribose-phosphate pyrophosphokinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P60891	Arts syndrome phosphoribosylpyrophosphate synthetase superactivity Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease X-linked recessive 5 deafness, X-linked 1 nonsyndromic genetic deafness intellectual disability peripheral neuropathy Weight Gain retinitis pigmentosa pancreatic ductal adenocarcinoma peripheral nervous system disease psoriasis ulcerative colitis Alzheimer disease Arts syndrome phosphoribosylpyrophosphate synthetase superactivity Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease X-linked recessive 5 deafness, X-linked 1 nonsyndromic genetic deafness intellectual disability peripheral neuropathy Weight Gain retinitis pigmentosa pancreatic ductal adenocarcinoma peripheral nervous system disease psoriasis ulcerative colitis Alzheimer disease cystic fibrosis malignant mesothelioma neurodegenerative disease osteosarcoma pancreatic intraductal papillary-mucinous carcinoma retinal degeneration colorectal cancer malignant colon neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia X-linked syndromic intellectual disability cone-rod dystrophy gout malignant ependymoma motor peripheral neuropathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.