8ZDD

Cryo-EM structure of the human ubiquitylated pre-40S ribosome with RIOK3 (without NOB1)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
K [auth L]	SCOP2B Superfamily	Nucleic acid-binding proteins	8052717	3000135	SCOP2B (2022-06-29)
K [auth L]	SCOP2B Superfamily	Ribosomal S17 N-terminal domain-like	8052715	3002138	SCOP2B (2022-06-29)
L [auth N]	SCOP2B Superfamily	S15/NS1 RNA-binding domain	8052959	3001284	SCOP2B (2022-06-29)
L [auth N]	SCOP2B Superfamily	Homeodomain-like	8052958	3000001	SCOP2B (2022-06-29)
M [auth O]	SCOP2B Superfamily	Translational machinery components	8098844	3000571	SCOP2B (2022-06-29)
N [auth V]	SCOP2B Superfamily	Glucocorticoid receptor-like (DNA-binding domain)	8053139	3000068	SCOP2B (2022-06-29)
O [auth W]	SCOP2B Superfamily	Ribosomal protein S8	8095469	3000709	SCOP2B (2022-06-29)
V [auth d]	SCOP2B Superfamily	Glucocorticoid receptor-like (DNA-binding domain)	8052572	3000068	SCOP2B (2022-06-29)
W [auth D]	SCOP2B Superfamily	Prokaryotic type KH domain (KH-domain type II)	8043545	3001043	SCOP2B (2022-06-29)
X [auth F]	SCOP2B Superfamily	Ribosomal protein S7	8066003	3000799	SCOP2B (2022-06-29)
Y [auth K]	SCOP2B Superfamily	Winged helix DNA-binding domain	8055714	3000034	SCOP2B (2022-06-29)
Z [auth M]	SCOP2B Superfamily	L30e-like	8063978	3001739	SCOP2B (2022-06-29)
BA [auth Q]	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8082685	3000100	SCOP2B (2022-06-29)
CA [auth S]	SCOP2B Superfamily	S13-like H2TH domain	8101555	3000053	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8052791	3001397	SCOP2B (2022-06-29)
DA [auth T]	SCOP2B Superfamily	Winged helix DNA-binding domain	8089318	3000034	SCOP2B (2022-06-29)
EA [auth U]	SCOP2B Superfamily	Ribosomal protein S10	8098806	3001336	SCOP2B (2022-06-29)
FA [auth Z]	SCOP2B Superfamily	Winged helix DNA-binding domain	8090992	3000034	SCOP2B (2022-06-29)
GA [auth c]	SCOP2B Superfamily	Nucleic acid-binding proteins	8063426	3000135	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Ribosomal S3Ae-like	8053212	3002166	SCOP2B (2022-06-29)
F [auth E]	SCOP2B Superfamily	Nucleic acid-binding proteins	8052756	3000135	SCOP2B (2022-06-29)
F [auth E]	SCOP2B Superfamily	Translation proteins SH3-like KOW motif containing domain	8052757	3000334	SCOP2B (2022-06-29)
F [auth E]	SCOP2B Superfamily	Alpha-L RNA-binding motif	8052755	3001473	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GS N-terminal domain-like	8053171	3000408	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	50S Ribosomal protein L14-like	8053077	3000433	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
J	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
J	PF00163	Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)	Ribosomal protein S4/S9 N-terminal domain	-	Family
J	PF01479	S4 domain (S4)	S4 domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.	Domain
K [auth L]	PF16205	Ribosomal_S17 N-terminal (Ribosomal_S17_N)	Ribosomal_S17 N-terminal	-	Family
K [auth L]	PF00366	Ribosomal protein S17 (Ribosomal_S17)	Ribosomal protein S17		Domain
L [auth N]	PF00312	Ribosomal protein S15 (Ribosomal_S15)	Ribosomal protein S15		Domain
M [auth O]	PF00411	Ribosomal protein S11 (Ribosomal_S11)	Ribosomal protein S11	-	Family
N [auth V]	PF01249	Ribosomal protein S21e (Ribosomal_S21e)	Ribosomal protein S21e	-	Family
O [auth W]	PF00410	Ribosomal protein S8 (Ribosomal_S8)	Ribosomal protein S8		Domain
P [auth X]	PF00164	Ribosomal protein S12/S23 (Ribosom_S12_S23)	Ribosomal protein S12/S23	This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.	Domain
Q [auth Y]	PF01282	Ribosomal protein S24e (Ribosomal_S24e)	Ribosomal protein S24e	-	Family
W [auth D]	PF07650	KH domain (KH_2)	KH domain		Domain
W [auth D]	PF00253	Ribosomal protein S14p/S29e (Ribosomal_S14)	Ribosomal protein S14p/S29e	-	Family
W [auth D]	PF00189	Ribosomal protein S3, C-terminal domain (Ribosomal_S3_C)	Ribosomal protein S3, C-terminal domain	This family contains a central domain Pfam:PF00013, hence the amino and carboxyl terminal domains are stored separately. This is a minimal carboxyl-terminal domain. Some are much longer.	Domain
X [auth F]	PF00177	Ribosomal protein S7p/S5e (Ribosomal_S7)	Ribosomal protein S7p/S5e	This family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.	Domain
Y [auth K]	PF03501	Plectin/S10 domain (S10_plectin)	Plectin/S10 domain	This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.	Domain
Z [auth M]	PF01248	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	Domain
AA [auth P]	PF00203	Ribosomal protein S19 (Ribosomal_S19)	Ribosomal protein S19		Domain
BA [auth Q]	PF00380	Ribosomal protein S9/S16 (Ribosomal_S9)	Ribosomal protein S9/S16	-	Family
CA [auth S]	PF00416	Ribosomal protein S13/S18 (Ribosomal_S13)	Ribosomal protein S13/S18	-	Family
C [auth A]	PF00318	Ribosomal protein S2 (Ribosomal_S2)	Ribosomal protein S2	-	Family
C [auth A]	PF16122	40S ribosomal protein SA C-terminus (40S_SA_C)	40S ribosomal protein SA C-terminus	-	Family
DA [auth T]	PF01090	Ribosomal protein S19e (Ribosomal_S19e)	Ribosomal protein S19e	-	Family
EA [auth U]	PF00338	Ribosomal protein S10p/S20e (Ribosomal_S10)	Ribosomal protein S10p/S20e	This family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.	Domain
EA [auth U]	PF22298	Tsr1, G-like domain (Tsr1_G-like)	Tsr1, G-like domain	This entry represents the G-like (guanine nucleotide-binding domain) domain, found in Tsr1, a protein required for normal export of the pre-40S particles from the nucleus to the cytoplasm during 40S ribosomal subunit synthesis [1-5]. This domain adop ...	This entry represents the G-like (guanine nucleotide-binding domain) domain, found in Tsr1, a protein required for normal export of the pre-40S particles from the nucleus to the cytoplasm during 40S ribosomal subunit synthesis [1-5]. This domain adopts a GTPase-like fold, but lacks a P-loop and is not predicted to bind GTP.	Domain
D [auth B]	PF01667	Ribosomal protein S27 (Ribosomal_S27e)	Ribosomal protein S27	-	Family
E [auth C]	PF03719	Ribosomal protein S5, C-terminal domain (Ribosomal_S5_C)	Ribosomal protein S5, C-terminal domain		Domain
E [auth C]	PF00333	Ribosomal protein S5, N-terminal domain (Ribosomal_S5)	Ribosomal protein S5, N-terminal domain		Domain
F [auth E]	PF00900	Ribosomal family S4e (Ribosomal_S4e)	Ribosomal family S4e	-	Family
F [auth E]	PF16121	40S ribosomal protein S4 C-terminus (40S_S4_C)	40S ribosomal protein S4 C-terminus	-	Family
F [auth E]	PF08071	RS4NT (NUC023) domain (RS4NT)	RS4NT (NUC023) domain	This is the N-terminal domain of Ribosomal S4 / S4e proteins. This domain is associated with S4 and KOW domains [1].	Domain
F [auth E]	PF00467	KOW motif (KOW)	KOW motif	-	Family
G	PF01092	Ribosomal protein S6e (Ribosomal_S6e)	Ribosomal protein S6e	-	Family
G	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
I	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
I	PF01201	Ribosomal protein S8e (Ribosomal_S8e)	Ribosomal protein S8e	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 2]	18S rRNA	-	-	-
J	Small ribosomal subunit protein uS4	translation regulator activity RNA binding binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process biosynthetic process cytoplasmic translation metabolic process primary metabolic process protein metabolic process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process biosynthetic process cytoplasmic translation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytosolic ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
K [auth L]	Small ribosomal subunit protein uS17	RNA binding binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
L [auth N]	Small ribosomal subunit protein uS15	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome mRNA binding small ribosomal subunit rRNA binding rRNA binding mRNA 5'-UTR binding	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process RNA splicing negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of RNA splicing nucleic acid metabolic process negative regulation of RNA splicing regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytosolic ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
M [auth O]	Small ribosomal subunit protein uS11	translation regulator activity RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome mRNA 5'-UTR binding mRNA binding	ribonucleoprotein complex biogenesis RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process cellular component biogenesis nucleobase-containing compound metabolic process RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process biosynthetic process ribonucleoprotein complex biogenesis RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process cellular component biogenesis nucleobase-containing compound metabolic process RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process biosynthetic process maturation of SSU-rRNA cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process RNA processing rRNA metabolic process cytoplasmic translation protein metabolic process translation developmental process multicellular organismal process cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis organelle assembly protein-containing complex organization membraneless organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly regulation of cellular process negative regulation of biological process regulation of primary metabolic process negative regulation of RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription regulation of biological process negative regulation of transcription by RNA polymerase II negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm cytosolic ribosome ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
N [auth V]	Small ribosomal subunit protein eS21	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis nucleobase-containing compound metabolic process RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process maturation of SSU-rRNA RNA 3'-end processing cellular component organization or biogenesis RNA processing rRNA metabolic process endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleobase-containing compound biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA 3'-end processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	protein-containing complex intracellular anatomical structure small ribosomal subunit intracellular membraneless organelle ribosomal subunit intracellular organelle cellular anatomical structure ribonucleoprotein complex organelle membraneless organelle ribosome cytosolic ribosome cytoplasm cytosol protein-containing complex intracellular anatomical structure small ribosomal subunit intracellular membraneless organelle ribosomal subunit intracellular organelle cellular anatomical structure ribonucleoprotein complex organelle membraneless organelle ribosome cytosolic ribosome cytoplasm cytosol synapse cell junction cytosolic small ribosomal subunit membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen rough endoplasmic reticulum endoplasmic reticulum endomembrane system
O [auth W]	Small ribosomal subunit protein uS8	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	regulation of biological process regulation of cellular process biological regulation positive regulation of biological process cellular process cell cycle regulation of cell cycle positive regulation of cell cycle positive regulation of cellular process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation biosynthetic process cytoplasmic translation regulation of biological process regulation of cellular process biological regulation positive regulation of biological process cellular process cell cycle regulation of cell cycle positive regulation of cell cycle positive regulation of cellular process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation biosynthetic process cytoplasmic translation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
P [auth X]	Small ribosomal subunit protein uS12	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis cellular component organization organelle organization cellular component assembly stress granule assembly organelle assembly membraneless organelle assembly maintenance of translational fidelity	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cell junction cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm rough endoplasmic reticulum endoplasmic reticulum endomembrane system
Q [auth Y]	Small ribosomal subunit protein eS24	protein binding binding translation initiation factor binding RNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA processing rRNA metabolic process multicellular organismal process multicellular organismal-level homeostasis homeostatic process immune system process homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome membrane cytosolic ribosome cytoplasm cytosol preribosome small-subunit processome cytosolic small ribosomal subunit nucleoplasm endoplasmic reticulum endomembrane system
R [auth b]	Small ribosomal subunit protein eS27	DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding RNA binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis translation at synapse translation at presynapse RNA metabolic process rRNA processing nucleobase-containing compound biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA processing rRNA metabolic process organelle assembly protein-containing complex organization membraneless organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly translation at postsynapse	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit presynapse nucleoplasm
S [auth x]	RNA-binding protein PNO1	RNA binding binding nucleic acid binding	cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular process cellular component organization or biogenesis ribosomal small subunit biogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen preribosome protein-containing complex ribonucleoprotein complex small-subunit processome nucleoplasm
B [auth R]	Small ribosomal subunit protein eS17	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cytoplasmic translation cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cytoplasmic translation cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA processing rRNA metabolic process multicellular organismal process multicellular organismal-level homeostasis homeostatic process immune system process homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
T [auth u]	Pre-rRNA-processing protein TSR1 homolog	RNA binding binding U3 snoRNA binding snoRNA binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding RNA binding binding U3 snoRNA binding snoRNA binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribonucleoprotein complex biogenesis RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process biosynthetic process endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribonucleoprotein complex biogenesis RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process cellular component organization or biogenesis RNA processing rRNA metabolic process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA ribosomal small subunit biogenesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen cytoplasm cytosol nucleoplasm
U [auth t]	Protein LTV1 homolog	-	establishment of organelle localization cellular localization ribonucleoprotein complex biogenesis nucleocytoplasmic transport transport nuclear transport ribosomal subunit export from nucleus intracellular transport establishment of localization protein-containing complex localization cellular component biogenesis localization ribosome biogenesis ribosomal small subunit export from nucleus organelle localization establishment of organelle localization cellular localization ribonucleoprotein complex biogenesis nucleocytoplasmic transport transport nuclear transport ribosomal subunit export from nucleus intracellular transport establishment of localization protein-containing complex localization cellular component biogenesis localization ribosome biogenesis ribosomal small subunit export from nucleus organelle localization establishment of localization in cell cellular process cellular component organization or biogenesis nuclear export ribosome localization ribosomal small subunit biogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen preribosome protein-containing complex ribonucleoprotein complex preribosome, small subunit precursor
V [auth d]	Small ribosomal subunit protein uS14	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction protein-containing complex intracellular anatomical structure small ribosomal subunit intracellular membraneless organelle ribosomal subunit intracellular organelle ribonucleoprotein complex organelle membraneless organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction protein-containing complex intracellular anatomical structure small ribosomal subunit intracellular membraneless organelle ribosomal subunit intracellular organelle ribonucleoprotein complex organelle membraneless organelle ribosome extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle organelle subcompartment cytoplasmic side of membrane membrane intracellular membrane-bounded organelle endomembrane system side of membrane cytoplasmic side of rough endoplasmic reticulum membrane rough endoplasmic reticulum endoplasmic reticulum subcompartment bounding membrane of organelle rough endoplasmic reticulum membrane nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane cytosol cytosolic small ribosomal subunit cytosolic ribosome nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
W [auth D]	Small ribosomal subunit protein uS3	DNA binding oxidized DNA binding oxidized pyrimidine DNA binding binding damaged DNA binding nucleic acid binding structural molecule activity structural constituent of ribosome ubiquitin-like protein conjugating enzyme binding protein binding enzyme binding cytoskeletal protein binding microtubule binding tubulin binding DNA binding oxidized DNA binding oxidized pyrimidine DNA binding binding damaged DNA binding nucleic acid binding structural molecule activity structural constituent of ribosome ubiquitin-like protein conjugating enzyme binding protein binding enzyme binding cytoskeletal protein binding microtubule binding tubulin binding RNA binding mRNA binding double-stranded DNA binding supercoiled DNA binding protein-containing complex binding DNA-(apurinic or apyrimidinic site) endonuclease activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid class I DNA-(apurinic or apyrimidinic site) endonuclease activity lyase activity catalytic activity carbon-oxygen lyase activity oxidized purine DNA binding small ribosomal subunit rRNA binding rRNA binding protein kinase A binding iron-sulfur cluster binding metal cluster binding small molecule binding Hsp90 protein binding heat shock protein binding DNA endonuclease activity endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity DNA nuclease activity Hsp70 protein binding protein-folding chaperone binding kinase binding protein kinase binding transcription factor binding DNA-binding transcription factor binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process biosynthetic process translational initiation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process biosynthetic process translational initiation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of cellular response to stress regulation of signal transduction regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stress intrinsic apoptotic signaling pathway in response to DNA damage signal transduction intrinsic apoptotic signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of programmed cell death regulation of apoptotic process biological regulation positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of base-excision repair positive regulation of metabolic process positive regulation of DNA repair base-excision repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process DNA repair positive regulation of nucleobase-containing compound metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair positive regulation of DNA metabolic process positive regulation of base-excision repair regulation of metabolic process regulation of DNA metabolic process cell division negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination protein ubiquitination negative regulation of protein modification process negative regulation of cellular process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process cell cycle chromosome segregation cell cycle process positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component organization cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis response to chemical response to TNF agonist immune response-regulating cell surface receptor signaling pathway positive regulation of T cell receptor signaling pathway regulation of antigen receptor-mediated signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response regulation of T cell receptor signaling pathway T cell receptor signaling pathway immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response positive regulation of antigen receptor-mediated signaling pathway positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization microtubule cytoskeleton organization microtubule polymerization or depolymerization positive regulation of protein polymerization protein polymerization positive regulation of microtubule polymerization or depolymerization positive regulation of cytoskeleton organization regulation of microtubule-based process microtubule polymerization positive regulation of supramolecular fiber organization regulation of organelle organization organelle organization positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process intracellular signaling cassette phosphorus metabolic process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of MAPK cascade positive regulation of JUN kinase activity regulation of MAPK cascade positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of JUN kinase activity MAPK cascade regulation of phosphorylation post-transcriptional regulation of gene expression negative regulation of translation negative regulation of gene expression negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process negative regulation of DNA repair negative regulation of nucleobase-containing compound metabolic process negative regulation of response to stimulus negative regulation of DNA metabolic process organelle assembly membraneless organelle assembly spindle assembly spindle organization regulation of endodeoxyribonuclease activity positive regulation of endodeoxyribonuclease activity positive regulation of deoxyribonuclease activity positive regulation of nuclease activity positive regulation of hydrolase activity regulation of hydrolase activity cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to chemical stimulus response to peptide cellular response to tumor necrosis factor response to cytokine cellular response to cytokine stimulus response to tumor necrosis factor multicellular organismal process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation cytoplasmic translation regulation of cytokine production cytokine production regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production positive regulation of cytokine production regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle protein-containing complex NF-kappaB complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane mitochondrion mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane anchoring junction cell junction focal adhesion cell-substrate junction membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen ruffle cell leading edge plasma membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane mitotic spindle cytoskeleton spindle microtubule cytoskeleton nucleoplasm ribosome cytosolic ribosome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit ribonucleoprotein complex mitochondrial matrix endoplasmic reticulum endomembrane system
X [auth F]	Small ribosomal subunit protein uS7	RNA binding binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome mRNA binding	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process biological regulation regulation of biological quality regulation of translational fidelity cytoplasmic translation biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process biological regulation regulation of biological quality regulation of translational fidelity cytoplasmic translation cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis organelle assembly protein-containing complex organization membraneless organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytosolic ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
Y [auth K]	Small ribosomal subunit protein eS10	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane cytosolic ribosome ribosome cytoplasm cytosol cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex nucleoplasm
Z [auth M]	Small ribosomal subunit protein eS12	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process positive regulation of canonical Wnt signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway biological regulation regulation of response to stimulus regulation of cell communication positive regulation of signaling maintenance of translational fidelity	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane cytosolic ribosome ribosome cytoplasm cytosol Golgi apparatus endomembrane system preribosome protein-containing complex ribonucleoprotein complex small-subunit processome cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
AA [auth P]	Small ribosomal subunit protein uS19	protein binding binding MDM2/MDM4 family protein binding RNA binding nucleic acid binding structural molecule activity structural constituent of ribosome DNA binding enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity molecular function regulator activity protein binding binding MDM2/MDM4 family protein binding RNA binding nucleic acid binding structural molecule activity structural constituent of ribosome DNA binding enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity molecular function regulator activity enzyme inhibitor activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction signal transduction by p53 class mediator regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling developmental process multicellular organismal process cellular developmental process ossification cell differentiation osteoblast differentiation establishment of organelle localization cellular localization ribonucleoprotein complex biogenesis nucleocytoplasmic transport transport nuclear transport ribosomal subunit export from nucleus intracellular transport establishment of localization protein-containing complex localization cellular component biogenesis localization ribosome biogenesis ribosomal small subunit export from nucleus organelle localization establishment of localization in cell cellular component organization or biogenesis nuclear export ribosome localization RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process metabolic process macromolecule metabolic process RNA processing rRNA metabolic process cytoplasmic translation protein metabolic process translation ribosomal small subunit biogenesis organelle assembly protein-containing complex organization membraneless organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytosolic ribosome membraneless organelle intracellular membraneless organelle ribosome cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex
BA [auth Q]	Small ribosomal subunit protein uS9	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis nucleobase-containing compound metabolic process RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process maturation of SSU-rRNA cellular component organization or biogenesis RNA processing rRNA metabolic process nucleobase-containing compound biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process response to peptide response to stimulus response to chemical response to cytokine response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome membrane cytosolic ribosome cytoplasm cytosol preribosome small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cytosolic small ribosomal subunit nucleoplasm
CA [auth S]	Small ribosomal subunit protein uS13	RNA binding binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction protein-containing complex intracellular anatomical structure small ribosomal subunit intracellular membraneless organelle ribosomal subunit intracellular organelle ribonucleoprotein complex organelle membraneless organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction protein-containing complex intracellular anatomical structure small ribosomal subunit intracellular membraneless organelle ribosomal subunit intracellular organelle ribonucleoprotein complex organelle membraneless organelle ribosome membrane cytosolic ribosome cytoplasm cytosol extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C [auth A]	Small ribosomal subunit protein uS2	protein binding binding virus receptor activity exogenous protein binding RNA binding nucleic acid binding structural molecule activity structural constituent of ribosome extracellular matrix binding laminin binding cell adhesion molecule binding laminin receptor activity cell adhesion mediator activity DNA binding protein binding binding virus receptor activity exogenous protein binding RNA binding nucleic acid binding structural molecule activity structural constituent of ribosome extracellular matrix binding laminin binding cell adhesion molecule binding laminin receptor activity cell adhesion mediator activity DNA binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus immune system process defense response to other organism response to stress innate immune response antiviral innate immune response response to external biotic stimulus response to virus ribonucleoprotein complex biogenesis organelle assembly protein-containing complex organization membraneless organelle assembly ribosomal small subunit assembly protein-RNA complex assembly ribosomal small subunit biogenesis cellular component organization cellular component biogenesis ribosome biogenesis organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis ribosome assembly	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytosolic ribosome membraneless organelle intracellular membraneless organelle ribosome cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex
DA [auth T]	Small ribosomal subunit protein eS19	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome fibroblast growth factor binding protein binding growth factor binding kinase binding enzyme binding protein kinase binding identical protein binding	regulation of immune effector process multicellular organismal process positive regulation of response to biotic stimulus regulation of cellular process positive regulation of respiratory burst response to stimulus response to biotic stimulus positive regulation of metabolic process regulation of respiratory burst involved in inflammatory response positive regulation of immune response positive regulation of inflammatory response regulation of immune system process positive regulation of immune system process regulation of biological process regulation of immune effector process multicellular organismal process positive regulation of response to biotic stimulus regulation of cellular process positive regulation of respiratory burst response to stimulus response to biotic stimulus positive regulation of metabolic process regulation of respiratory burst involved in inflammatory response positive regulation of immune response positive regulation of inflammatory response regulation of immune system process positive regulation of immune system process regulation of biological process respiratory burst involved in defense response immune response response to other organism regulation of innate immune response response to external stimulus regulation of inflammatory response immune effector process regulation of response to stimulus defense response to other organism respiratory burst involved in inflammatory response positive regulation of defense response regulation of immune response positive regulation of multicellular organismal process metabolic process inflammatory response regulation of metabolic process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response regulation of multicellular organismal process positive regulation of immune effector process response to external biotic stimulus regulation of respiratory burst positive regulation of cellular process production of molecular mediator involved in inflammatory response positive regulation of innate immune response positive regulation of respiratory burst involved in inflammatory response defense response biological regulation defense response to symbiont respiratory burst immune system process cellular process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis nucleobase-containing compound metabolic process RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process maturation of SSU-rRNA cellular component organization or biogenesis RNA processing rRNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process biosynthetic process macromolecule metabolic process cellular component organization nucleus organization organelle organization nucleolus organization cytoplasmic translation protein metabolic process translation cell chemotaxis cellular response to stimulus chemotaxis monocyte chemotaxis leukocyte migration cellular response to chemical stimulus taxis response to chemical mononuclear cell migration myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion humoral immune response antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide developmental process cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation cell differentiation anatomical structure development homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing negative regulation of biological process regulation of cell differentiation regulation of cell development negative regulation of immune response negative regulation of metabolic process negative regulation of immune effector process negative regulation of response to external stimulus negative regulation of defense response negative regulation of respiratory burst involved in inflammatory response negative regulation of multicellular organismal process regulation of developmental process negative regulation of response to biotic stimulus negative regulation of inflammatory response negative regulation of respiratory burst negative regulation of cellular process negative regulation of response to stimulus negative regulation of immune system process negative regulation of innate immune response defense response to Gram-negative bacterium defense response to bacterium response to bacterium organelle assembly protein-containing complex organization membraneless organelle assembly ribosomal small subunit assembly protein-RNA complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytosolic ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
EA [auth U]	Small ribosomal subunit protein uS10	enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity molecular function regulator activity enzyme inhibitor activity protein binding binding MDM2/MDM4 family protein binding RNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction signal transduction by p53 class mediator regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling biosynthetic process cytoplasmic translation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process	cellular anatomical structure membrane intracellular organelle intracellular anatomical structure cytosolic ribosome organelle membraneless organelle intracellular membraneless organelle ribosome cytoplasm cytosol extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure membrane intracellular organelle intracellular anatomical structure cytosolic ribosome organelle membraneless organelle intracellular membraneless organelle ribosome cytoplasm cytosol extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
FA [auth Z]	Small ribosomal subunit protein eS25	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA processing rRNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome cytosolic ribosome cytoplasm cytosol extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse cytosolic small ribosomal subunit nucleoplasm
GA [auth c]	Small ribosomal subunit protein eS28	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA processing rRNA metabolic process organelle assembly protein-containing complex organization membraneless organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly maturation of SSU-rRNA	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome preribosome small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction organelle subcompartment cytoplasmic side of membrane membrane endomembrane system side of membrane cytoplasmic side of rough endoplasmic reticulum membrane rough endoplasmic reticulum endoplasmic reticulum subcompartment bounding membrane of organelle rough endoplasmic reticulum membrane nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane cytosol cytosolic small ribosomal subunit cytosolic ribosome nucleoplasm
HA [auth g]	Small ribosomal subunit protein RACK1	molecular function inhibitor activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity transporter regulator activity channel inhibitor activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding death domain binding molecular function inhibitor activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity transporter regulator activity channel inhibitor activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding death domain binding BH3 domain binding BH domain binding protein domain specific binding cell adhesion molecule binding cadherin binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase regulator activity involved in apoptotic process peptidase activator activity peptidase activator activity involved in apoptotic process molecular adaptor activity protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding protein kinase binding identical protein binding translation regulator activity protein-macromolecule adaptor activity signaling adaptor activity SH2 domain binding cyclin binding RNA binding nucleic acid binding protein homodimerization activity protein dimerization activity protein kinase inhibitor activity protein tyrosine kinase inhibitor activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity ribonucleoprotein complex binding protein-containing complex binding ribosome binding protein kinase C binding	protein localization positive regulation of protein localization to plasma membrane regulation of localization Golgi to plasma membrane transport establishment of protein localization nitrogen compound transport regulation of cellular process establishment of protein localization to plasma membrane positive regulation of establishment of protein localization Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization positive regulation of protein localization to cell periphery protein localization positive regulation of protein localization to plasma membrane regulation of localization Golgi to plasma membrane transport establishment of protein localization nitrogen compound transport regulation of cellular process establishment of protein localization to plasma membrane positive regulation of establishment of protein localization Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization positive regulation of protein localization to cell periphery positive regulation of Golgi to plasma membrane protein transport regulation of biological process protein localization to cell periphery establishment of protein localization to membrane positive regulation of protein localization to membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane establishment of localization regulation of Golgi to plasma membrane protein transport positive regulation of protein localization Golgi vesicle transport cellular localization post-Golgi vesicle-mediated transport regulation of protein localization transport positive regulation of biological process positive regulation of protein transport regulation of protein localization to membrane positive regulation of cellular process regulation of transport protein localization to plasma membrane biological regulation regulation of establishment of protein localization regulation of protein transport regulation of vesicle-mediated transport vesicle-mediated transport to the plasma membrane positive regulation of transport protein transport regulation of cellular localization macromolecule localization cellular process regulation of protein localization to plasma membrane regulation of protein binding regulation of molecular function negative regulation of protein binding regulation of binding negative regulation of binding negative regulation of molecular function cellular component disassembly ribosome disassembly rescue of stalled ribosome primary metabolic process translation gene expression macromolecule biosynthetic process cellular component organization organelle organization organelle disassembly biosynthetic process translational elongation metabolic process cellular component organization or biogenesis macromolecule metabolic process protein metabolic process developmental process multicellular organismal process regulation of embryonic development regulation of multicellular organismal development regulation of gastrulation regulation of developmental process embryonic morphogenesis positive regulation of gastrulation embryo development gastrulation positive regulation of developmental process multicellular organism development anatomical structure morphogenesis anatomical structure development positive regulation of embryonic development positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of anatomical structure morphogenesis positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death regulation of growth negative regulation of biological process growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth negative regulation of cellular process regulation of mitochondrial depolarization positive regulation of membrane depolarization positive regulation of mitochondrial depolarization mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization regulation of biological quality regulation of membrane potential positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular response to stimulus regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus intrinsic apoptotic signaling pathway positive regulation of intracellular signal transduction apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling cell division regulation of cell division pigmentation regulation of cellular response to stress endoplasmic reticulum unfolded protein response regulation of response to endoplasmic reticulum stress regulation of endoplasmic reticulum unfolded protein response cellular response to stress response to stress regulation of response to stress negative regulation of endoplasmic reticulum unfolded protein response response to endoplasmic reticulum stress negative regulation of response to endoplasmic reticulum stress cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein response to topologically incorrect protein negative regulation of Wnt signaling pathway Wnt signaling pathway cell surface receptor signaling pathway regulation of Wnt signaling pathway post-transcriptional regulation of gene expression negative regulation of translation negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process homeostatic process response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose response to chemical glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of peptidyl-serine phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process peptidyl-amino acid modification phosphorus metabolic process negative regulation of peptidyl-serine phosphorylation protein phosphorylation phosphorylation negative regulation of protein phosphorylation negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of translational frameshifting regulation of translational elongation negative regulation of translational frameshifting translational frameshifting negative regulation of translational elongation regulation of hydrogen peroxide-mediated programmed cell death programmed cell death in response to reactive oxygen species negative regulation of apoptotic signaling pathway negative regulation of programmed cell death negative regulation of apoptotic process intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway cellular response to oxidative stress cellular response to chemical stress negative regulation of hydrogen peroxide-mediated programmed cell death cellular response to reactive oxygen species hydrogen peroxide-mediated programmed cell death negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to hydrogen peroxide response to reactive oxygen species negative regulation of intrinsic apoptotic signaling pathway response to oxidative stress negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of smoothened signaling pathway regulation of smoothened signaling pathway smoothened signaling pathway cytoplasmic translation rhythmic process cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus response to growth factor positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion import into cell negative regulation of transport negative regulation of endocytosis negative regulation of phagocytosis phagocytosis regulation of endocytosis negative regulation of cellular component organization regulation of phagocytosis endocytosis positive regulation of phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process cell cycle regulation of cell cycle regulation of establishment of cell polarity regulation of establishment or maintenance of cell polarity establishment of cell polarity establishment or maintenance of cell polarity	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex small ribosomal subunit intracellular membraneless organelle ribosomal subunit intracellular organelle ribonucleoprotein complex membraneless organelle ribosome IRE1-RACK1-PP2A complex perinuclear region of cytoplasm phagocytic cup cell periphery plasma membrane membrane mitochondrion intracellular membrane-bounded organelle midbody nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytosolic small ribosomal subunit cytosolic ribosome
IA [auth p]	Serine/threonine-protein kinase RIO3	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity histone H3S57 kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H3 kinase activity histone modifying activity catalytic activity histone kinase activity histone H2AS121 kinase activity histone H2A kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity histone H3S57 kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H3 kinase activity histone modifying activity catalytic activity histone kinase activity histone H2AS121 kinase activity histone H2A kinase activity Rho-dependent protein serine/threonine kinase activity AMP-activated protein kinase activity histone H2AT120 kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein serine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding enzyme binding protease binding caspase binding histone H3T11 kinase activity histone H3S28 kinase activity histone H3T6 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2B kinase activity histone H2BS36 kinase activity histone H3T3 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity cation binding metal ion binding histone H2BS14 kinase activity	cellular response to nitrogen compound cellular response to stimulus cellular response to chemical stimulus cellular response to dsRNA response to stimulus response to chemical response to dsRNA response to nitrogen compound cellular process cell cycle chromosome segregation cell cycle process regulation of cellular process signaling cellular response to nitrogen compound cellular response to stimulus cellular response to chemical stimulus cellular response to dsRNA response to stimulus response to chemical response to dsRNA response to nitrogen compound cellular process cell cycle chromosome segregation cell cycle process regulation of cellular process signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation negative regulation of signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus regulation of cellular component organization negative regulation of cellular component organization protein-containing complex organization regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis ribonucleoprotein complex biogenesis RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process biosynthetic process maturation of SSU-rRNA metabolic process macromolecule metabolic process RNA processing rRNA metabolic process multicellular organismal process positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of interferon-beta production interferon-beta production positive regulation of cellular process regulation of biosynthetic process positive regulation of type I interferon production type I interferon production regulation of macromolecule metabolic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of interferon-beta production positive regulation of cytokine production regulation of metabolic process regulation of type I interferon production positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway MDA-5 signaling pathway immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway regulation of innate immune response regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus intracellular receptor signaling pathway negative regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress regulation of MDA-5 signaling pathway negative regulation of MDA-5 signaling pathway positive regulation of innate immune response negative regulation of immune system process response to dsDNA cellular response to dsDNA defense response to virus response to virus cellular response to virus	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex preribosome, small subunit precursor
JA [auth i], KA [auth j]	Ubiquitin	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome protein tag activity molecular tag activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding cation binding ion binding metal ion binding RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome protein tag activity molecular tag activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding cation binding ion binding metal ion binding small molecule binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process cellular process macromolecule metabolic process protein metabolic process protein ubiquitination macromolecule modification catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process cellular process macromolecule metabolic process protein metabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal biosynthetic process cytoplasmic translation translation gene expression macromolecule biosynthetic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytoplasm cytosol cell periphery plasma membrane nucleoplasm organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane endocytic vesicle cytosolic ribosome ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cell junction endosome membrane endosome mitochondrial membrane mitochondrion organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
D [auth B]	Small ribosomal subunit protein eS1	RNA binding mRNA 5'-UTR binding binding nucleic acid binding mRNA binding structural molecule activity structural constituent of ribosome	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process cellular developmental process cell differentiation cytoplasmic translation biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process developmental process cellular developmental process cell differentiation cytoplasmic translation regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm endoplasmic reticulum endomembrane system
E [auth C]	Small ribosomal subunit protein uS5	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome fibroblast growth factor binding protein binding growth factor binding mRNA binding cell adhesion molecule binding cadherin binding enzyme binding	regulation of cellular process regulation of protein modification process regulation of catalytic activity positive regulation of protein metabolic process positive regulation of biological process regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process protein ubiquitination positive regulation of macromolecule metabolic process regulation of cellular process regulation of protein modification process regulation of catalytic activity positive regulation of protein metabolic process positive regulation of biological process regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process protein ubiquitination positive regulation of macromolecule metabolic process regulation of ubiquitin-protein transferase activity protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of cellular process positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of biological process positive regulation of transferase activity regulation of post-translational protein modification regulation of protein metabolic process biological regulation positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process positive regulation of ubiquitin-protein transferase activity regulation of molecular function macromolecule modification metabolic process cellular process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal biosynthetic process cytoplasmic translation translation gene expression macromolecule biosynthetic process	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytosolic ribosome membraneless organelle intracellular membraneless organelle ribosome cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex
F [auth E]	Small ribosomal subunit protein eS4, X isoform	RNA binding binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process positive regulation of protein metabolic process positive regulation of translation positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process positive regulation of protein metabolic process positive regulation of translation positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process regulation of biosynthetic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cytoplasmic translation cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex cytosolic ribosome preribosome small-subunit processome synapse cytosolic small ribosomal subunit
G	Small ribosomal subunit protein eS6	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome protein binding kinase binding enzyme binding protein kinase binding	developmental process multicellular organismal process erythrocyte development cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid cell development developmental process multicellular organismal process erythrocyte development cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid cell development homeostasis of number of cells cellular process myeloid cell homeostasis erythrocyte homeostasis placenta development animal organ development regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death multicellular organism development anatomical structure morphogenesis embryonic morphogenesis embryo development gastrulation sexual reproduction reproductive process multicellular organismal reproductive process oogenesis cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation gamete generation germ cell development mammalian oogenesis stage positive regulation of programmed cell death positive regulation of biological process positive regulation of apoptotic process positive regulation of cellular process ribonucleoprotein complex biogenesis RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process biosynthetic process metabolic process macromolecule metabolic process cellular component organization or biogenesis RNA processing rRNA metabolic process leukocyte apoptotic process lymphocyte apoptotic process leukocyte homeostasis T cell homeostasis activation-induced cell death of T cells T cell apoptotic process lymphocyte homeostasis cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation cytoplasmic translation protein metabolic process translation mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process ribosomal small subunit biogenesis cellular response to stimulus TOR signaling response to stimulus signaling intracellular signal transduction cell communication signal transduction immune response cell activation involved in immune response leukocyte proliferation immune effector process T cell proliferation involved in immune response T cell activation involved in immune response mononuclear cell proliferation lymphocyte proliferation leukocyte activation involved in immune response lymphocyte activation involved in immune response T cell proliferation chemical homeostasis glucose homeostasis carbohydrate homeostasis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection nucleoplasm cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome cytosolic ribosome preribosome small-subunit processome perinuclear region of cytoplasm cell body cytosolic small ribosomal subunit endoplasmic reticulum endomembrane system
H	Small ribosomal subunit protein eS7	mRNA 3'-UTR binding RNA binding binding nucleic acid binding mRNA binding structural molecule activity structural constituent of ribosome protein binding kinase binding enzyme binding protein kinase binding enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity mRNA 3'-UTR binding RNA binding binding nucleic acid binding mRNA binding structural molecule activity structural constituent of ribosome protein binding kinase binding enzyme binding protein kinase binding enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity molecular function regulator activity enzyme inhibitor activity mRNA 5'-UTR binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process neural crest cell differentiation cellular developmental process animal organ development mesenchyme development tissue development stem cell differentiation cell differentiation anatomical structure development cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process neural crest cell differentiation cellular developmental process animal organ development mesenchyme development tissue development stem cell differentiation cell differentiation anatomical structure development cellular process mesenchymal cell differentiation regulation of biosynthetic process regulation of biological process regulation of cellular process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process negative regulation of biological process regulation of ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of catabolic process protein catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing nucleobase-containing compound biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction intrinsic apoptotic signaling pathway regulation of signaling positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction signal transduction by p53 class mediator cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of intrinsic apoptotic signaling pathway apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling multicellular organismal process embryonic epithelial tube formation chordate embryonic development tube formation embryo development multicellular organism development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis system development morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure cytoplasmic translation translation ribosomal small subunit biogenesis negative regulation of post-translational protein modification negative regulation of ubiquitin protein ligase activity regulation of protein modification process regulation of catalytic activity regulation of protein ubiquitination negative regulation of catalytic activity regulation of transferase activity regulation of ubiquitin protein ligase activity negative regulation of ubiquitin-protein transferase activity protein ubiquitination negative regulation of transferase activity negative regulation of protein modification process regulation of ubiquitin-protein transferase activity negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification negative regulation of molecular function regulation of molecular function macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton cytoplasm cytosol nucleoplasm ribosome protein-containing complex cytosolic ribosome preribosome ribonucleoprotein complex small-subunit processome synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit endoplasmic reticulum endomembrane system
I	Small ribosomal subunit protein eS8	RNA binding binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis nucleobase-containing compound metabolic process RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process maturation of SSU-rRNA cellular component organization or biogenesis RNA processing rRNA metabolic process nucleobase-containing compound biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
J	IPR002942	RNA-binding S4 domain	Domain
J	IPR022801	Small ribosomal subunit protein uS4	Family
J	IPR018079	Small ribosomal subunit protein uS4, conserved site	Conserved Site
J	IPR001912	Small ribosomal subunit protein uS4, N-terminal	Domain
J	IPR005710	Small ribosomal subunit protein uS4, eukaryotic/archaeal	Family
J	IPR036986	RNA-binding S4 domain superfamily	Homologous Superfamily
K [auth L]	IPR019979	Small ribosomal subunit protein uS17, conserved site	Conserved Site
K [auth L]	IPR032440	Small ribosomal subunit protein uS17, N-terminal	Domain
K [auth L]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
K [auth L]	IPR000266	Small ribosomal subunit protein uS17	Family
K [auth L]	IPR028333	Small ribosomal subunit protein uS17, archaeal/eukaryotic	Family
L [auth N]	IPR009068	uS15/NS1, RNA-binding domain superfamily	Homologous Superfamily
L [auth N]	IPR000589	Small ribosomal subunit protein uS15	Family
L [auth N]	IPR023029	Small ribosomal subunit protein uS15, archaea/eukaryotes	Family
L [auth N]	IPR012606	Small ribosomal subunit protein uS15, N-terminal	Domain
M [auth O]	IPR036967	Small ribosomal subunit protein uS11 superfamily	Homologous Superfamily
M [auth O]	IPR018102	Small ribosomal subunit protein uS11, conserved site	Conserved Site
M [auth O]	IPR001971	Small ribosomal subunit protein uS11	Family
N [auth V]	IPR038579	Small ribosomal subunit protein eS21 superfamily	Homologous Superfamily
N [auth V]	IPR018279	Small ribosomal subunit protein eS21, conserved site	Conserved Site
N [auth V]	IPR001931	Small ribosomal subunit protein eS21	Family
O [auth W]	IPR047863	Small ribosomal subunit protein uS8, conserved site	Conserved Site
O [auth W]	IPR000630	Small ribosomal subunit protein uS8	Family
O [auth W]	IPR035987	Small ribosomal subunit protein uS8 superfamily	Homologous Superfamily
P [auth X]	IPR006032	Small ribosomal subunit protein uS12	Family
P [auth X]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
P [auth X]	IPR005680	Small ribosomal subunit protein uS12, eukaryotic/archaeal	Family
Q [auth Y]	IPR053709	Eukaryotic Ribosomal Protein eS24	Homologous Superfamily
Q [auth Y]	IPR001976	Small ribosomal subunit protein eS24	Family
Q [auth Y]	IPR012678	Ribosomal protein uL23/eL15/eS24 core domain superfamily	Homologous Superfamily
Q [auth Y]	IPR018098	Small ribosomal subunit protein eS24 conserved site	Conserved Site
R [auth b]	IPR023407	Small ribosomal subunit protein eS27, zinc-binding domain superfamily	Homologous Superfamily
R [auth b]	IPR000592	Small ribosomal subunit protein eS27	Family
R [auth b]	IPR011332	Zinc-binding ribosomal protein	Homologous Superfamily
S [auth x]	IPR004087	K Homology domain	Domain
S [auth x]	IPR055211	PNO1, second type I KH domain	Domain
S [auth x]	IPR036612	K Homology domain, type 1 superfamily	Homologous Superfamily
S [auth x]	IPR055212	PNO1, first type I KH domain	Domain
B [auth R]	IPR001210	Small ribosomal subunit protein eS17	Family
B [auth R]	IPR036401	Small ribosomal subunit protein eS17 superfamily	Homologous Superfamily
B [auth R]	IPR018273	Small ribosomal subunit protein eS17, conserved site	Conserved Site
T [auth u]	IPR007034	Ribosome biogenesis protein BMS1/TSR1, C-terminal	Domain
T [auth u]	IPR030387	Bms1/Tsr1-type G domain	Domain
T [auth u]	IPR039761	Ribosome biogenesis protein Bms1/Tsr1	Family
T [auth u]	IPR012948	AARP2CN	Domain
U [auth t]	IPR007307	Low temperature viability protein Ltv1	Family
V [auth d]	IPR018271	Small ribosomal subunit protein uS14, conserved site	Conserved Site
V [auth d]	IPR043140	Small ribosomal subunit protein uS14 superfamily	Homologous Superfamily
V [auth d]	IPR001209	Small ribosomal subunit protein uS14	Family
V [auth d]	IPR039744	Small ribosomal subunit protein uS14, eukaryotes/archaea	Family
W [auth D]	IPR009019	K homology domain superfamily, prokaryotic type	Homologous Superfamily
W [auth D]	IPR015946	K homology domain-like, alpha/beta	Homologous Superfamily
W [auth D]	IPR036419	Ribosomal protein S3, C-terminal domain superfamily	Homologous Superfamily
W [auth D]	IPR004044	K Homology domain, type 2	Domain
W [auth D]	IPR001351	Small ribosomal subunit protein uS3, C-terminal	Domain
W [auth D]	IPR005703	Small ribosomal subunit protein uS3, eukaryotic/archaeal	Family
W [auth D]	IPR018280	Small ribosomal subunit protein uS3, conserved site	Conserved Site
X [auth F]	IPR023798	Small ribosomal subunit protein uS7 domain	Domain
X [auth F]	IPR020606	Small ribosomal subunit protein uS7, conserved site	Conserved Site
X [auth F]	IPR036823	Small ribosomal subunit protein uS7 domain superfamily	Homologous Superfamily
X [auth F]	IPR000235	Small ribosomal subunit protein uS7	Family
X [auth F]	IPR005716	Ribosomal protein uS7, eukaryotic/archaeal	Family
Y [auth K]	IPR037447	Small ribosomal subunit protein eS10	Family
Y [auth K]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
Y [auth K]	IPR005326	Plectin/eS10, N-terminal	Domain
Z [auth M]	IPR000530	Small ribosomal subunit protein eS12	Family
Z [auth M]	IPR004038	Ribosomal protein eL8/eL30/eS12/Gadd45	Domain
Z [auth M]	IPR047860	Small ribosomal subunit protein eS12, conserved site	Conserved Site
Z [auth M]	IPR029064	Ribosomal protein eL30-like superfamily	Homologous Superfamily
AA [auth P]	IPR023575	Small ribosomal subunit protein uS19, superfamily	Homologous Superfamily
AA [auth P]	IPR020934	Small ribosomal subunit protein uS19, conserved site	Conserved Site
AA [auth P]	IPR005713	Small ribosomal subunit protein uS19, eukaryotic/archaeal	Family
AA [auth P]	IPR002222	Small ribosomal subunit protein uS19	Family
BA [auth Q]	IPR020574	Small ribosomal subunit protein uS9, conserved site	Conserved Site
BA [auth Q]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
BA [auth Q]	IPR000754	Small ribosomal subunit protein uS9	Family
BA [auth Q]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
CA [auth S]	IPR018269	Small ribosomal subunit protein uS13, conserved site	Conserved Site
CA [auth S]	IPR027437	Small ribosomal subunit protein uS13, C-terminal	Homologous Superfamily
CA [auth S]	IPR001892	Small ribosomal subunit protein uS13	Family
CA [auth S]	IPR010979	Small ribosomal subunit protein uS13-like, H2TH	Homologous Superfamily
C [auth A]	IPR023591	Small ribosomal subunit protein uS2, flavodoxin-like domain superfamily	Homologous Superfamily
C [auth A]	IPR001865	Small ribosomal subunit protein uS2	Family
C [auth A]	IPR032281	Small ribosomal subunit protein uS2, C-terminal domain	Domain
C [auth A]	IPR027504	Small ribosomal subunit protein uS2, vertebrates	Family
C [auth A]	IPR005707	Small ribosomal subunit protein uS2, eukaryotic/archaeal	Family
C [auth A]	IPR018130	Small ribosomal subunit protein uS2, conserved site	Conserved Site
C [auth A]	IPR027498	Small ribosomal subunit protein uS2, eukaryotic	Family
DA [auth T]	IPR018277	Small ribosomal subunit protein eS19, conserved site	Conserved Site
DA [auth T]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
DA [auth T]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
DA [auth T]	IPR001266	Small ribosomal subunit protein eS19	Family
EA [auth U]	IPR027486	Small ribosomal subunit protein uS10 domain	Domain
EA [auth U]	IPR036838	Small ribosomal subunit protein uS10 domain superfamily	Homologous Superfamily
EA [auth U]	IPR005729	Small ribosomal subunit protein uS10, eukaryotic/archaeal	Family
EA [auth U]	IPR018268	Small ribosomal subunit protein uS10, conserved site	Conserved Site
EA [auth U]	IPR001848	Small ribosomal subunit protein uS10	Family
FA [auth Z]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
FA [auth Z]	IPR004977	Small ribosomal subunit protein eS25	Family
GA [auth c]	IPR028626	Ribosomal protein eS28 conserved site	Conserved Site
GA [auth c]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
GA [auth c]	IPR000289	Small ribosomal subunit protein eS28	Family
HA [auth g]	IPR019775	WD40 repeat, conserved site	Conserved Site
HA [auth g]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
HA [auth g]	IPR045223	Small ribosomal subunit protein RACK1-like	Family
HA [auth g]	IPR020472	G-protein beta WD-40 repeat	Repeat
HA [auth g]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
HA [auth g]	IPR001680	WD40 repeat	Repeat
IA [auth p]	IPR018935	RIO kinase, conserved site	Conserved Site
IA [auth p]	IPR000687	RIO kinase	Domain
IA [auth p]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
IA [auth p]	IPR051272	RIO-type Ser/Thr kinase	Family
IA [auth p]	IPR017406	Serine/threonine-protein kinase Rio3	Family
JA [auth i], KA [auth j]	IPR019954	Ubiquitin conserved site	Conserved Site
JA [auth i], KA [auth j]	IPR050158	Ubiquitin and ubiquitin-like	Family
JA [auth i], KA [auth j]	IPR011332	Zinc-binding ribosomal protein	Homologous Superfamily
JA [auth i], KA [auth j]	IPR000626	Ubiquitin-like domain	Domain
JA [auth i], KA [auth j]	IPR038582	Small ribosomal subunit protein eS31 eukaryotic-type superfamily	Homologous Superfamily
JA [auth i], KA [auth j]	IPR002906	Small ribosomal subunit protein eS31	Domain
JA [auth i], KA [auth j]	IPR019956	Ubiquitin domain	Domain
JA [auth i], KA [auth j]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
D [auth B]	IPR001593	Small ribosomal subunit protein eS1	Family
D [auth B]	IPR018281	Small ribosomal subunit protein eS1, conserved site	Conserved Site
D [auth B]	IPR027500	Small ribosomal subunit protein eS1, eukaryotes	Family
E [auth C]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
E [auth C]	IPR018192	Small ribosomal subunit protein uS5, N-terminal, conserved site	Conserved Site
E [auth C]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
E [auth C]	IPR000851	Small ribosomal subunit protein uS5	Family
E [auth C]	IPR005711	Small ribosomal subunit protein uS5, eukaryotic/archaeal	Family
E [auth C]	IPR005324	Small ribosomal subunit protein uS5, C-terminal	Domain
E [auth C]	IPR013810	Small ribosomal subunit protein uS5, N-terminal	Domain
F [auth E]	IPR013843	Small ribosomal subunit protein eS4, N-terminal	Domain
F [auth E]	IPR032277	Small ribosomal subunit protein eS4, C-terminal domain	Domain
F [auth E]	IPR013845	Small ribosomal subunit protein eS4, central region	Domain
F [auth E]	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
F [auth E]	IPR041982	Small ribosomal subunit protein eS4, KOW domain	Domain
F [auth E]	IPR018199	Small ribosomal subunit protein eS4, N-terminal, conserved site	Conserved Site
F [auth E]	IPR002942	RNA-binding S4 domain	Domain
F [auth E]	IPR000876	Small ribosomal subunit protein eS4	Family
F [auth E]	IPR038237	Small ribosomal subunit protein eS4, central domain superfamily	Homologous Superfamily
F [auth E]	IPR036986	RNA-binding S4 domain superfamily	Homologous Superfamily
F [auth E]	IPR005824	KOW	Domain
G	IPR018282	Small ribosomal subunit protein eS6, conserved site	Conserved Site
G	IPR001377	Small ribosomal subunit protein eS6	Family
G	IPR014401	Small ribosomal subunit protein eS6-like	Family
H	IPR000554	Small ribosomal subunit protein eS7	Family
H	IPR047861	Small ribosomal subunit protein eS7, conserved site	Conserved Site
I	IPR042563	Small ribosomal subunit protein eS8 subdomain, eukaryotes	Homologous Superfamily
I	IPR022309	Ribosomal protein eS8/ribosomal biogenesis NSA2	Family
I	IPR018283	Small ribosomal subunit protein eS8, conserved site	Conserved Site
I	IPR001047	Small ribosomal subunit protein eS8	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
J	Pharos: P46781	alcoholic liver cirrhosis prostate carcinoma lung cancer Takayasu arteritis Malignant neoplasm of breast
K [auth L]	Pharos: P62280	diabetes mellitus medulloblastoma Hodgkins lymphoma plasma cell myeloma lung cancer
L [auth N]	Pharos: P62277	diabetes mellitus primary angle-closure glaucoma
M [auth O]	Pharos: P62263	chromosome 5q deletion syndrome carcinoma Hypoxia sarcomatoid carcinoma neutropenia undifferentiated carcinoma congenital anemia ovarian cancer breast cancer mammary neoplasms, animal
N [auth V]	Pharos: P63220	retinal disease astrocytic tumor colorectal adenoma Disease Exacerbation gastric neoplasm large cell medulloblastoma medulloblastoma plasma cell myeloma atypical teratoid rhabdoid tumor colorectal cancer glioblastoma lung cancer oligodendroglioma prostate carcinoma benign prostatic hyperplasia retinal disease astrocytic tumor colorectal adenoma Disease Exacerbation gastric neoplasm large cell medulloblastoma medulloblastoma plasma cell myeloma atypical teratoid rhabdoid tumor colorectal cancer glioblastoma lung cancer oligodendroglioma prostate carcinoma benign prostatic hyperplasia diabetes mellitus gastric cancer hereditary diffuse gastric adenocarcinoma osteosarcoma
O [auth W]	Pharos: P62244	breast cancer glioblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm cystic fibrosis lung adenocarcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Diamond-Blackfan anemia malignant glioma ovarian cancer subependymal giant cell astrocytoma
P [auth X]	Pharos: P62266	brachycephaly, trichomegaly, and developmental delay intellectual disability osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast carcinoma large cell medulloblastoma pancreatic intraductal papillary-mucinous carcinoma polycystic ovary syndrome cystic fibrosis medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
Q [auth Y]	Pharos: P62847	Diamond-Blackfan anemia Diamond-Blackfan anemia 3 Aase Smith syndrome 2 lung cancer non-alcoholic fatty liver disease aplastic anemia diabetes mellitus hematopoietic and lymphoid system neoplasm lymphoplasmacytic lymphoma ovarian cancer congenital anemia inherited aplastic anemia MALT lymphoma plasma cell myeloma
R [auth b]	Pharos: P42677	Diamond-Blackfan anemia Diamond-Blackfan anemia 17 Aase Smith syndrome 2 hematopoietic and lymphoid system neoplasm aplastic anemia inherited aplastic anemia congenital anemia prostate carcinoma
S [auth x]	Pharos: Q9NRX1	glioblastoma large cell medulloblastoma osteosarcoma hypertensive disorder lung cancer psoriasis invasive ductal breast carcinoma malignant mesothelioma tuberculosis
B [auth R]	Pharos: P08708	Diamond-Blackfan anemia Diamond-Blackfan anemia 4 Aase Smith syndrome 2 hematopoietic and lymphoid system neoplasm lung cancer aplastic anemia inherited aplastic anemia ovarian cancer congenital anemia large cell medulloblastoma
T [auth u]	Pharos: Q2NL82	astrocytic tumor breast cancer large cell medulloblastoma medulloblastoma osteosarcoma plasma cell myeloma attention deficit hyperactivity disorder, inattentive type carcinoma of esophagus lung cancer non-small cell lung carcinoma ovarian cancer squamous cell carcinoma autism spectrum disorder heart disease malignant ependymoma astrocytic tumor breast cancer large cell medulloblastoma medulloblastoma osteosarcoma plasma cell myeloma attention deficit hyperactivity disorder, inattentive type carcinoma of esophagus lung cancer non-small cell lung carcinoma ovarian cancer squamous cell carcinoma autism spectrum disorder heart disease malignant ependymoma oligodendroglioma pancreatic ductal adenocarcinoma
U [auth t]	Pharos: Q96GA3	diabetes mellitus ovarian cancer
V [auth d]	Pharos: P62273	Diamond-Blackfan anemia Diamond-Blackfan anemia 13 Aase Smith syndrome 2 glioblastoma lung cancer aplastic anemia hematopoietic and lymphoid system neoplasm malignant glioma congenital anemia inherited aplastic anemia ovarian cancer
W [auth D]	Pharos: P23396	melanoma Chromosomal Instability atypical teratoid rhabdoid tumor diabetes mellitus lymphoplasmacytic lymphoma Pick disease large cell medulloblastoma medulloblastoma plasma cell myeloma cutaneous melanoma lung cancer
X [auth F]	Pharos: P46782	acute myeloid leukemia diabetes mellitus MALT lymphoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer lung cancer ovarian cancer
Y [auth K]	Pharos: P46783	Diamond-Blackfan anemia Diamond-Blackfan anemia 9 Aase Smith syndrome 2 hematopoietic and lymphoid system neoplasm aplastic anemia inherited aplastic anemia congenital anemia
Z [auth M]	Pharos: P25398	diabetes mellitus
AA [auth P]	Pharos: P62841	B-cell chronic lymphocytic leukemia Diamond-Blackfan anemia gastric cancer hereditary diffuse gastric adenocarcinoma B-CELL MALIGNANCY, LOW-GRADE gastric neoplasm diabetes mellitus hematopoietic and lymphoid system neoplasm
BA [auth Q]	Pharos: P62249	atypical teratoid rhabdoid tumor lung cancer osteosarcoma plasma cell myeloma glioblastoma lymphoplasmacytic lymphoma ovarian cancer primitive neuroectodermal tumor large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
CA [auth S]	Pharos: P62269	cervical cancer triple-negative breast carcinoma
C [auth A]	Pharos: P08865	familial isolated congenital asplenia Neoplasm Invasiveness amyotrophic lateral sclerosis lung adenocarcinoma
DA [auth T]	Pharos: P39019	Diamond-Blackfan anemia Diamond-Blackfan anemia 1 prostate cancer large cell medulloblastoma medulloblastoma Aase Smith syndrome 2 astrocytic tumor congenital anemia glioblastoma inherited aplastic anemia lung cancer plasma cell myeloma anemia atypical teratoid rhabdoid tumor gastric cancer Diamond-Blackfan anemia Diamond-Blackfan anemia 1 prostate cancer large cell medulloblastoma medulloblastoma Aase Smith syndrome 2 astrocytic tumor congenital anemia glioblastoma inherited aplastic anemia lung cancer plasma cell myeloma anemia atypical teratoid rhabdoid tumor gastric cancer hematopoietic and lymphoid system neoplasm intellectual disability primitive neuroectodermal tumor aplastic anemia breast fibroadenoma diabetes mellitus gastric neoplasm hereditary diffuse gastric adenocarcinoma
EA [auth U]	Pharos: P60866	adenoma cutaneous lupus erythematosus glioblastoma Hereditary Nonpolyposis Colorectal Neoplasms malignant mesothelioma psoriasis atypical teratoid rhabdoid tumor cystic fibrosis lung cancer ovarian cancer systemic lupus erythematosus breast cancer familial colorectal cancer type X Lynch syndrome prostate carcinoma
FA [auth Z]	Pharos: P62851	acute myeloid leukemia heart disease
GA [auth c]	Pharos: P62857	Diamond-Blackfan anemia Diamond-Blackfan anemia 15 with mandibulofacial dysostosis Weight Gain cutaneous lupus erythematosus inherited aplastic anemia metabolic syndrome X psoriasis aplastic anemia heart disease lung cancer osteosarcoma congenital anemia hematopoietic and lymphoid system neoplasm medulloblastoma ovarian cancer
HA [auth g]	Pharos: P63244	squamous cell carcinoma plasma cell myeloma Alcoholic Intoxication, Chronic bipolar disorder glioblastoma lymphoplasmacytic lymphoma medulloblastoma oral cavity neoplasm pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor astrocytic tumor cystic fibrosis large cell medulloblastoma malignant glioma osteosarcoma squamous cell carcinoma plasma cell myeloma Alcoholic Intoxication, Chronic bipolar disorder glioblastoma lymphoplasmacytic lymphoma medulloblastoma oral cavity neoplasm pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor astrocytic tumor cystic fibrosis large cell medulloblastoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor diabetes mellitus lung cancer oligodendroglioma ovarian cancer
IA [auth p]	Pharos: O14730	adenoma heart disease malignant colon neoplasm metabolic syndrome X pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia dermatomyositis hereditary spastic paraplegia malignant ependymoma ovarian cancer spina bifida Gaucher disease large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma
JA [auth i], KA [auth j]	Pharos: P62979	acute myeloid leukemia large cell medulloblastoma Diamond-Blackfan anemia lung carcinoma hematopoietic and lymphoid system neoplasm ulcerative colitis
E [auth C]	Pharos: P15880	Hypoxia atrial fibrillation
F [auth E]	Pharos: P62701	breast carcinoma breast cancer Malignant neoplasm of breast ovarian cancer lung cancer
G	Pharos: P62753	breast carcinoma breast cancer Disease Progression hepatocellular carcinoma lung cancer gastric cancer hereditary diffuse gastric adenocarcinoma gastric neoplasm pancreatic intraductal papillary-mucinous neoplasm
H	Pharos: P62081	Diamond-Blackfan anemia Diamond-Blackfan anemia 8 breast carcinoma Aase Smith syndrome 2 diabetes mellitus hematopoietic and lymphoid system neoplasm MALT lymphoma aplastic anemia congenital anemia inherited aplastic anemia breast cancer
I	Pharos: P62241	Weight Gain breast carcinoma Parkinson disease breast cancer