8FXZ

Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (heptameric ring)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth H]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054503	3000071	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054503	3000071	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054503	3000071	SCOP2B (2022-06-29)
F [auth E]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054503	3000071	SCOP2B (2022-06-29)
H [auth G]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054503	3000071	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054503	3000071	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054503	3000071	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth D], G [auth F], I, A, C [auth B], E [auth D], G [auth F], I, K, M	PF04887	Poxvirus M2 protein (Pox_M2)	Poxvirus M2 protein	-	Family
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth D], G [auth F], I, A, C [auth B], E [auth D], G [auth F], I, K, M	CPXV040 protein	-	symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host NF-kappaB cascade symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host signal transduction pathway symbiont-mediated suppression of host NF-kappaB cascade modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction	cellular anatomical structure extracellular region host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	T-lymphocyte activation antigen CD80	protein binding binding virus receptor activity exogenous protein binding molecular transducer activity coreceptor activity signaling receptor activity molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	response to stimulus immune response immune system process cellular response to stimulus biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus response to stimulus immune response immune system process cellular response to stimulus biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid cellular process response to external biotic stimulus response to molecule of bacterial origin negative regulation of lymphocyte proliferation multicellular organismal process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation regulation of biological process cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion biological regulation cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of alpha-beta T cell activation positive regulation of T cell differentiation alpha-beta T cell differentiation involved in immune response regulation of cell development multicellular organism development positive regulation of immune response cell differentiation regulation of T-helper cell differentiation alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation T-helper cell differentiation positive regulation of cell development T-helper 1 type immune response regulation of T-helper 1 type immune response immune effector process regulation of response to stimulus regulation of T-helper 1 cell differentiation positive regulation of alpha-beta T cell differentiation regulation of developmental process cell development positive regulation of leukocyte cell-cell adhesion CD4-positive, alpha-beta T cell differentiation positive regulation of T-helper cell differentiation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation alpha-beta T cell differentiation T cell activation involved in immune response positive regulation of cell differentiation leukocyte activation involved in immune response positive regulation of immune effector process positive regulation of cellular process hemopoiesis regulation of CD4-positive, alpha-beta T cell activation regulation of immune effector process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation involved in immune response positive regulation of T-helper 1 cell differentiation positive regulation of developmental process positive regulation of cell activation anatomical structure development positive regulation of leukocyte activation T cell differentiation positive regulation of immune system process developmental process positive regulation of T cell activation regulation of adaptive immune response positive regulation of alpha-beta T cell activation regulation of immune response positive regulation of multicellular organismal process leukocyte differentiation cellular developmental process positive regulation of biological process regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation positive regulation of response to stimulus positive regulation of CD4-positive, alpha-beta T cell activation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains alpha-beta T cell activation involved in immune response positive regulation of hemopoiesis CD4-positive, alpha-beta T cell activation lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development positive regulation of cell adhesion T cell differentiation involved in immune response adaptive immune response T-helper 1 cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation cell surface receptor signaling pathway signaling signal transduction cell communication positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-2 production interleukin-2 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of interleukin-2 production regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process granulocyte macrophage colony-stimulating factor production positive regulation of protein metabolic process positive regulation of granulocyte macrophage colony-stimulating factor production regulation of primary metabolic process protein metabolic process regulation of granulocyte macrophage colony-stimulating factor production regulation of protein metabolic process primary metabolic process positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription lymphocyte costimulation T cell costimulation intracellular signal transduction positive regulation of cell communication regulation of signaling positive regulation of signal transduction regulation of signal transduction regulation of cell communication positive regulation of signaling positive regulation of cell population proliferation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of leukocyte proliferation positive regulation of mononuclear cell proliferation regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation lymphocyte mediated immunity T cell mediated immunity negative regulation of lymphocyte mediated immunity leukocyte mediated immunity regulation of T cell mediated immunity negative regulation of response to stimulus negative regulation of immune response negative regulation of immune effector process negative regulation of adaptive immune response negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth D], G [auth F], I, A, C [auth B], E [auth D], G [auth F], I, K, M	IPR006971	Poxvirus M2	Family
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR037676	CD80, IgC-like domain	Domain
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR013106	Immunoglobulin V-set domain	Domain
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR003599	Immunoglobulin domain subtype	Domain
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR051713	T-cell Activation and Immune Regulation Protein	Family
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR042711	CD80, immunoglobulin variable domain	Domain
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR013162	CD80-like, immunoglobulin C2-set	Domain
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth H], D [auth C], F [auth E], H [auth G], J, B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	Pharos: P33681	primary biliary cholangitis vitiligo celiac disease psoriasis skin disease arthritic joint disease Biliary Cirrhosis, Secondary cutaneous lupus erythematosus hematologic disease invasive ductal breast carcinoma lung disease ovarian cancer systemic lupus erythematosus autoimmune disease cancer primary biliary cholangitis vitiligo celiac disease psoriasis skin disease arthritic joint disease Biliary Cirrhosis, Secondary cutaneous lupus erythematosus hematologic disease invasive ductal breast carcinoma lung disease ovarian cancer systemic lupus erythematosus autoimmune disease cancer IgA glomerulonephritis juvenile idiopathic arthritis lymphatic system disease rheumatoid arthritis tuberculosis Hashimoto thyroiditis interstitial cystitis lung carcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.