8FXZ

Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (heptameric ring)

PDB DOI: https://doi.org/10.2210/pdb8FXZ/pdb
EM Map EMD-29549: EMDB EMDataResource

Classification: VIRAL PROTEIN
Organism(s): Cowpox virus (Brighton Red), Homo sapiens
Expression System: Homo sapiens
Mutation(s): No

Deposited: 2023-01-25 Released: 2025-02-05
Deposition Author(s): Elliott, J.I., Adams, L.J., Nelson, C.A., Fremont, D.H.
Funding Organization(s): National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

Experimental Data Snapshot

Method: ELECTRON MICROSCOPY
Resolution: 2.86 Å
Aggregation State: PARTICLE
Reconstruction Method: SINGLE PARTICLE

wwPDB Validation 3D Report Full Report

This is version 1.0 of the entry. See complete history.

Literature

Structure basis of poxvirus mediated sabotage of T-cell costimulation

Elliott, J.I., Adams, L.J., Jethva, P.N., Gross, M.L., Nelson, C.A., Fremont, D.H.

To be published.

Macromolecule Content

Total Structure Weight: 331.38 kDa
Atom Count: 17,675
Modelled Residue Count: 2,163
Deposited Residue Count: 2,849
Unique protein chains: 2

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
CPXV040 protein	A C [auth B] E [auth D] G [auth F] I A, C [auth B], E [auth D], G [auth F], I, K, M	206	Cowpox virus (Brighton Red)	Mutation(s): 0 Gene Names: CPXV040 CDS
UniProt
Find proteins for Q8QN22 (Cowpox virus (strain Brighton Red)) Explore Q8QN22 Go to UniProtKB: Q8QN22
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q8QN22
Sequence Annotations Expand
Reference Sequence

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 2
Molecule	Chains	Sequence Length	Organism	Details	Image
T-lymphocyte activation antigen CD80	B [auth H] D [auth C] F [auth E] H [auth G] J B [auth H], D [auth C], F [auth E], H [auth G], J, L, N	201	Homo sapiens	Mutation(s): 0 Gene Names: CD80, CD28LG, CD28LG1, LAB7
UniProt & NIH Common Fund Data Resources
Find proteins for P33681 (Homo sapiens) Explore P33681 Go to UniProtKB: P33681
PHAROS: P33681 GTEx: ENSG00000121594
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P33681
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 1 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
NAG Query on NAG Download Ideal Coordinates CCD File SDF format, chain AA [auth I] SDF format, chain BA [auth I] SDF format, chain CA [auth I] SDF format, chain DA [auth K] SDF format, chain EA [auth K] SDF format, chain FA [auth K] SDF format, chain GA [auth M] SDF format, chain HA [auth M] SDF format, chain IA [auth M] SDF format, chain O [auth A] SDF format, chain P [auth A] SDF format, chain Q [auth A] SDF format, chain R [auth B] SDF format, chain S [auth B] SDF format, chain T [auth B] SDF format, chain U [auth D] SDF format, chain V [auth D] SDF format, chain W [auth D] SDF format, chain X [auth F] SDF format, chain Y [auth F] SDF format, chain Z [auth F] MOL2 format, chain AA [auth I] MOL2 format, chain BA [auth I] MOL2 format, chain CA [auth I] MOL2 format, chain DA [auth K] MOL2 format, chain EA [auth K] MOL2 format, chain FA [auth K] MOL2 format, chain GA [auth M] MOL2 format, chain HA [auth M] MOL2 format, chain IA [auth M] MOL2 format, chain O [auth A] MOL2 format, chain P [auth A] MOL2 format, chain Q [auth A] MOL2 format, chain R [auth B] MOL2 format, chain S [auth B] MOL2 format, chain T [auth B] MOL2 format, chain U [auth D] MOL2 format, chain V [auth D] MOL2 format, chain W [auth D] MOL2 format, chain X [auth F] MOL2 format, chain Y [auth F] MOL2 format, chain Z [auth F] mmCIF format, chain AA [auth I] mmCIF format, chain BA [auth I] mmCIF format, chain CA [auth I] mmCIF format, chain DA [auth K] mmCIF format, chain EA [auth K] mmCIF format, chain FA [auth K] mmCIF format, chain GA [auth M] mmCIF format, chain HA [auth M] mmCIF format, chain IA [auth M] mmCIF format, chain O [auth A] mmCIF format, chain P [auth A] mmCIF format, chain Q [auth A] mmCIF format, chain R [auth B] mmCIF format, chain S [auth B] mmCIF format, chain T [auth B] mmCIF format, chain U [auth D] mmCIF format, chain V [auth D] mmCIF format, chain W [auth D] mmCIF format, chain X [auth F] mmCIF format, chain Y [auth F] mmCIF format, chain Z [auth F]	AA [auth I] BA [auth I] CA [auth I] DA [auth K] EA [auth K] AA [auth I], BA [auth I], CA [auth I], DA [auth K], EA [auth K], FA [auth K], GA [auth M], HA [auth M], IA [auth M], O [auth A], P [auth A], Q [auth A], R [auth B], S [auth B], T [auth B], U [auth D], V [auth D], W [auth D], X [auth F], Y [auth F], Z [auth F]	2-acetamido-2-deoxy-beta-D-glucopyranose C₈ H₁₅ N O₆ OVRNDRQMDRJTHS-FMDGEEDCSA-N		Interactions Focus chain AA [auth I] Focus chain BA [auth I] Focus chain CA [auth I] Focus chain DA [auth K] Focus chain EA [auth K] Focus chain FA [auth K] Focus chain GA [auth M] Focus chain HA [auth M] Focus chain IA [auth M] Focus chain O [auth A] Focus chain P [auth A] Focus chain Q [auth A] Focus chain R [auth B] Focus chain S [auth B] Focus chain T [auth B] Focus chain U [auth D] Focus chain V [auth D] Focus chain W [auth D] Focus chain X [auth F] Focus chain Y [auth F] Focus chain Z [auth F] Interactions & Density Focus chain AA [auth I] Focus chain BA [auth I] Focus chain CA [auth I] Focus chain DA [auth K] Focus chain EA [auth K] Focus chain FA [auth K] Focus chain GA [auth M] Focus chain HA [auth M] Focus chain IA [auth M] Focus chain O [auth A] Focus chain P [auth A] Focus chain Q [auth A] Focus chain R [auth B] Focus chain S [auth B] Focus chain T [auth B] Focus chain U [auth D] Focus chain V [auth D] Focus chain W [auth D] Focus chain X [auth F] Focus chain Y [auth F] Focus chain Z [auth F]