9BFP

Cryo-EM structure of Sevenless extracellular domain (monomer)

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein sevenless	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity boss receptor activity GPI-linked ephrin receptor activity epidermal growth factor receptor activity protein-hormone receptor activity insulin receptor activity macrophage colony-stimulating factor receptor activity histone H3Y41 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity platelet-derived growth factor receptor activity platelet-derived growth factor alpha-receptor activity placental growth factor receptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity stem cell factor receptor activity brain-derived neurotrophic factor receptor activity neurotrophin receptor activity fibroblast growth factor receptor activity histone H2AXY142 kinase activity histone H2AX kinase activity insulin-like growth factor receptor activity hepatocyte growth factor receptor activity	multicellular organismal process multicellular organismal-level homeostasis homeostatic process germ-line stem-cell niche homeostasis anatomical structure homeostasis cellular response to stimulus compound eye photoreceptor fate commitment regulation of cellular process cellular developmental process response to stimulus sensory organ development photoreceptor cell differentiation signaling visual system development multicellular organismal process multicellular organismal-level homeostasis homeostatic process germ-line stem-cell niche homeostasis anatomical structure homeostasis cellular response to stimulus compound eye photoreceptor fate commitment regulation of cellular process cellular developmental process response to stimulus sensory organ development photoreceptor cell differentiation signaling visual system development cell surface receptor protein tyrosine kinase signaling pathway cell communication eye morphogenesis multicellular organism development neurogenesis R7 cell fate commitment compound eye morphogenesis neuron differentiation cell differentiation eye photoreceptor cell differentiation photoreceptor cell fate commitment anatomical structure development animal organ morphogenesis signal transduction sensory system development enzyme-linked receptor protein signaling pathway system development developmental process sevenless signaling pathway regulation of biological process eye photoreceptor cell fate commitment cell surface receptor signaling pathway eye development neuron fate commitment animal organ development biological regulation nervous system development generation of neurons anatomical structure morphogenesis compound eye development sensory organ morphogenesis compound eye photoreceptor cell differentiation R7 cell differentiation cellular process cell fate commitment sensory perception of light stimulus system process sensory perception nervous system process visual perception	cell periphery cellular anatomical structure plasma membrane membrane protein-containing complex receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR008266	Tyrosine-protein kinase, active site	Active Site
A	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A	IPR000719	Protein kinase domain	Domain
A	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
A	IPR003961	Fibronectin type III	Domain
A	IPR000033	LDLR class B repeat	Repeat
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR050122	Receptor Tyrosine Kinase	Family
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.