9BFR

Cryo-EM structure of Bride of Sevenless extracellular domain (dimer, Sevenless-bound form)

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein bride of sevenless	glutamate receptor activity G protein-coupled glutamate receptor activity molecular transducer activity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity sevenless binding protein binding binding signaling receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity glutamate receptor activity G protein-coupled glutamate receptor activity molecular transducer activity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity sevenless binding protein binding binding signaling receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	multicellular organismal process compound eye photoreceptor fate commitment cellular developmental process sensory organ development photoreceptor cell differentiation visual system development eye morphogenesis multicellular organism development neurogenesis R7 cell fate commitment compound eye morphogenesis neuron differentiation cell differentiation eye photoreceptor cell differentiation photoreceptor cell fate commitment multicellular organismal process compound eye photoreceptor fate commitment cellular developmental process sensory organ development photoreceptor cell differentiation visual system development eye morphogenesis multicellular organism development neurogenesis R7 cell fate commitment compound eye morphogenesis neuron differentiation cell differentiation eye photoreceptor cell differentiation photoreceptor cell fate commitment anatomical structure development animal organ morphogenesis sensory system development system development developmental process eye photoreceptor cell fate commitment eye development neuron fate commitment animal organ development nervous system development generation of neurons anatomical structure morphogenesis compound eye development sensory organ morphogenesis compound eye photoreceptor cell differentiation R7 cell differentiation cellular process cell fate commitment multicellular organismal-level homeostasis homeostatic process germ-line stem-cell niche homeostasis anatomical structure homeostasis sensory perception of light stimulus system process sensory perception nervous system process visual perception chemical homeostasis lipid homeostasis cell development pattern specification process photoreceptor cell development eye photoreceptor cell development R8 cell-mediated photoreceptor organization compound eye photoreceptor development regionalization neuron development cellular response to stimulus regulation of cellular process response to stimulus signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway sevenless signaling pathway regulation of biological process cell surface receptor signaling pathway biological regulation response to hexose response to monosaccharide response to carbohydrate response to glucose response to chemical response to oxygen-containing compound glucose homeostasis carbohydrate homeostasis	cell periphery cellular anatomical structure plasma membrane membrane rhabdomere membrane rhabdomere microvillus plasma membrane bounded cell projection rhabdomere microvillus membrane cell projection rhabdomere actin-based cell projection plasma membrane region microvillus microvillus membrane cell periphery cellular anatomical structure plasma membrane membrane rhabdomere membrane rhabdomere microvillus plasma membrane bounded cell projection rhabdomere microvillus membrane cell projection rhabdomere actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017978	GPCR family 3, C-terminal	Domain
A, B	IPR002956	Bride of sevenless protein	Family
A, B	IPR050726	Metabotropic Glutamate Receptor	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.