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Data API
9CW3
|
pdb_00009cw3
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain bound with 6-(5-((4,4-difluoropiperidin-1-yl)methyl)-2,3-difluorophenyl)-4-methylpyridin-2-amine dihydrochloride
External Resource: Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Gene Ontology: Gene Product Annotation
Gene Ontology Database Homepage
Chains
Polymer
Molecular Function
Biological Process
Cellular Component
A
,
B
,
C
,
D
Nitric oxide synthase, brain
FMN binding
binding
nucleoside phosphate binding
ion binding
anion binding
nucleotide binding
heterocyclic compound binding
carbohydrate derivative binding
ribonucleotide binding
small molecule binding
flavin adenine dinucleotide binding
cation binding
organic acid binding
amino acid binding
FMN binding
binding
nucleoside phosphate binding
ion binding
anion binding
nucleotide binding
heterocyclic compound binding
carbohydrate derivative binding
ribonucleotide binding
small molecule binding
flavin adenine dinucleotide binding
cation binding
organic acid binding
amino acid binding
carboxylic acid binding
arginine binding
calcium channel activity
monoatomic cation transmembrane transporter activity
channel regulator activity
monoatomic ion channel activity
ion channel regulator activity
calcium channel regulator activity
monoatomic cation channel activity
passive transmembrane transporter activity
calcium ion transmembrane transporter activity
inorganic molecular entity transmembrane transporter activity
channel activity
inorganic cation transmembrane transporter activity
molecular function regulator activity
monoatomic ion transmembrane transporter activity
transporter activity
metal ion transmembrane transporter activity
transporter regulator activity
transmembrane transporter activity
transition metal ion binding
cadmium ion binding
metal ion binding
oxidoreductase activity
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
nitric-oxide synthase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
catalytic activity
protein binding
calmodulin binding
tetrahydrobiopterin binding
scaffold protein binding
transmembrane transporter binding
purine nucleotide binding
adenyl nucleotide binding
NADP binding
transferase activity, transferring nitrogenous groups
catalytic activity, acting on a protein
peptidyl-cysteine S-nitrosylase activity
transferase activity
sodium channel activity
sodium ion transmembrane transporter activity
sodium channel regulator activity
tetrapyrrole binding
heme binding
calcium-dependent protein binding
Less
multicellular organismal process
system process
muscle contraction
muscle system process
striated muscle contraction
heart process
regulation of biological process
regulation of heart contraction
regulation of system process
biological regulation
circulatory system process
regulation of blood circulation
positive regulation of the force of heart contraction
regulation of multicellular organismal process
multicellular organismal process
system process
muscle contraction
muscle system process
striated muscle contraction
heart process
regulation of biological process
regulation of heart contraction
regulation of system process
biological regulation
circulatory system process
regulation of blood circulation
positive regulation of the force of heart contraction
regulation of multicellular organismal process
regulation of biological quality
heart contraction
regulation of the force of heart contraction
blood circulation
cardiac muscle cell membrane repolarization
cardiac muscle cell action potential involved in contraction
regulation of membrane repolarization during action potential
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
ventricular cardiac muscle cell membrane repolarization
positive regulation of biological process
positive regulation of membrane repolarization during cardiac muscle cell action potential
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential
cardiac muscle contraction
regulation of membrane repolarization during ventricular cardiac muscle cell action potential
regulation of membrane repolarization during cardiac muscle cell action potential
actin filament-based process
regulation of action potential
cardiac muscle cell contraction
regulation of cardiac muscle cell membrane repolarization
ventricular cardiac muscle cell action potential
action potential
actin filament-based movement
membrane repolarization during action potential
regulation of membrane repolarization
cellular process
membrane repolarization during ventricular cardiac muscle cell action potential
cardiac muscle cell action potential
actin-mediated cell contraction
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of membrane potential
neuron apoptotic process
positive regulation of programmed cell death
regulation of cellular process
regulation of apoptotic process
regulation of programmed cell death
cell death
positive regulation of apoptotic process
apoptotic process
positive regulation of neuron apoptotic process
programmed cell death
positive regulation of cellular process
regulation of neuron apoptotic process
catabolic process
oxoacid metabolic process
glutamine family amino acid catabolic process
amino acid metabolic process
arginine catabolic process
organic acid metabolic process
organic acid catabolic process
alpha-amino acid metabolic process
glutamine family amino acid metabolic process
arginine metabolic process
carboxylic acid catabolic process
small molecule metabolic process
amino acid catabolic process
carboxylic acid metabolic process
L-amino acid catabolic process
primary metabolic process
L-amino acid metabolic process
proteinogenic amino acid metabolic process
alpha-amino acid catabolic process
proteinogenic amino acid catabolic process
metabolic process
small molecule catabolic process
response to stimulus
response to stress
multicellular organismal response to stress
cellular response to stimulus
positive regulation of cell communication
positive regulation of signal transduction
signaling
regulation of signal transduction
cell communication
positive regulation of response to stimulus
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
signal transduction
regulation of G protein-coupled receptor signaling pathway
regulation of signaling
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of G protein-coupled receptor signaling pathway
regulation of response to stimulus
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of cell communication
G protein-coupled receptor signaling pathway
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of signaling
regulation of localization
regulation of calcium ion transport
transport
regulation of transport
negative regulation of monoatomic ion transport
regulation of monoatomic ion transport
negative regulation of biological process
negative regulation of transport
establishment of localization
calcium ion transport
metal ion transport
negative regulation of calcium ion transport
localization
monoatomic ion transport
monoatomic cation transport
regulation of metal ion transport
cellular response to xenobiotic stimulus
xenobiotic catabolic process
xenobiotic metabolic process
response to xenobiotic stimulus
cellular response to chemical stimulus
response to chemical
cell redox homeostasis
cellular homeostasis
homeostatic process
developmental process
cellular developmental process
myoblast fusion
cell-cell fusion
muscle cell differentiation
myotube differentiation
muscle structure development
syncytium formation by plasma membrane fusion
anatomical structure morphogenesis
cell differentiation
anatomical structure formation involved in morphogenesis
anatomical structure development
syncytium formation
striated muscle cell differentiation
response to decreased oxygen levels
response to hypoxia
response to oxygen levels
response to abiotic stimulus
monoatomic ion transmembrane transport
regulation of monoatomic ion transmembrane transport
regulation of calcium ion transmembrane transport
monoatomic cation transmembrane transport
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
calcium ion transmembrane transport via high voltage-gated calcium channel
inorganic ion transmembrane transport
inorganic cation transmembrane transport
transmembrane transport
regulation of transmembrane transport
regulation of monoatomic cation transmembrane transport
calcium ion transmembrane transport
response to heat
response to temperature stimulus
cellular localization
regulation of calcium ion transport into cytosol
negative regulation of transmembrane transport
negative regulation of monoatomic ion transmembrane transport
negative regulation of cellular process
negative regulation of cation transmembrane transport
negative regulation of calcium ion transport into cytosol
calcium ion transmembrane import into cytosol
positive regulation of cytosolic calcium ion concentration
regulation of cellular localization
negative regulation of calcium ion transmembrane transport
negative regulation of cytosolic calcium ion concentration
calcium ion transport into cytosol
positive regulation of DNA-templated transcription
RNA metabolic process
positive regulation of macromolecule biosynthetic process
regulation of primary metabolic process
nucleobase-containing compound metabolic process
RNA biosynthetic process
nucleic acid biosynthetic process
positive regulation of metabolic process
DNA-templated transcription
regulation of RNA metabolic process
transcription by RNA polymerase II
positive regulation of biosynthetic process
positive regulation of macromolecule metabolic process
regulation of nucleobase-containing compound metabolic process
regulation of RNA biosynthetic process
regulation of biosynthetic process
regulation of transcription by RNA polymerase II
positive regulation of nucleobase-containing compound metabolic process
regulation of macromolecule metabolic process
positive regulation of transcription by RNA polymerase II
nucleobase-containing compound biosynthetic process
gene expression
macromolecule biosynthetic process
nucleic acid metabolic process
positive regulation of RNA metabolic process
regulation of gene expression
biosynthetic process
positive regulation of RNA biosynthetic process
regulation of macromolecule biosynthetic process
macromolecule metabolic process
regulation of DNA-templated transcription
regulation of metabolic process
response to hormone
response to endogenous stimulus
intracellular signal transduction
intracellular signaling cassette
regulation of cardiac muscle contraction by calcium ion signaling
regulation of cardiac muscle contraction
regulation of muscle system process
regulation of striated muscle contraction
calcium-mediated signaling
regulation of muscle contraction
negative regulation of potassium ion transport
regulation of potassium ion transport
potassium ion transport
nitric oxide mediated signal transduction
positive regulation of cation transmembrane transport
sodium ion transmembrane transport
regulation of sodium ion transport
regulation of sodium ion transmembrane transport
positive regulation of sodium ion transport
positive regulation of monoatomic ion transport
positive regulation of sodium ion transmembrane transport
positive regulation of transmembrane transport
positive regulation of monoatomic ion transmembrane transport
positive regulation of transport
sodium ion transport
regulation of tube diameter
regulation of tube size
vascular process in circulatory system
blood vessel diameter maintenance
vasodilation
regulation of anatomical structure size
cellular response to endogenous stimulus
cellular response to growth factor stimulus
response to growth factor
monoamine transport
import into cell
nitrogen compound transport
serotonin uptake
organic hydroxy compound transport
negative regulation of neurotransmitter transport
establishment of localization in cell
neurotransmitter reuptake
regulation of neurotransmitter uptake
regulation of neurotransmitter transport
regulation of serotonin uptake
serotonin transport
neurotransmitter transport
negative regulation of neurotransmitter uptake
negative regulation of serotonin uptake
neurotransmitter uptake
biological process involved in interspecies interaction between organisms
response to lipid
response to other organism
response to oxygen-containing compound
response to external stimulus
response to lipopolysaccharide
response to biotic stimulus
response to bacterium
response to external biotic stimulus
response to molecule of bacterial origin
regulation of blood pressure
negative regulation of blood pressure
nitric oxide metabolic process
nitric oxide biosynthetic process
reactive nitrogen species metabolic process
Less
cellular anatomical structure
photoreceptor inner segment
intracellular anatomical structure
cytoplasm
cytosol
cell periphery
sarcolemma
plasma membrane
membrane
intracellular organelle
cytoskeleton
organelle
membraneless organelle
intracellular membraneless organelle
cellular anatomical structure
photoreceptor inner segment
intracellular anatomical structure
cytoplasm
cytosol
cell periphery
sarcolemma
plasma membrane
membrane
intracellular organelle
cytoskeleton
organelle
membraneless organelle
intracellular membraneless organelle
neuron spine
synapse
neuron projection
dendritic spine
plasma membrane bounded cell projection
somatodendritic compartment
cell projection
postsynapse
cell junction
dendrite
dendritic tree
perinuclear region of cytoplasm
membrane-bounded organelle
intracellular membrane-bounded organelle
endomembrane system
sarcoplasm
endoplasmic reticulum
sarcoplasmic reticulum
mitochondrion
membrane microdomain
membrane raft
nucleus
membrane-enclosed lumen
intracellular organelle lumen
nucleoplasm
organelle lumen
nuclear lumen
protein-containing complex
postsynaptic density
neuron to neuron synapse
postsynaptic specialization
asymmetric synapse
Less
InterPro: Protein Family Classification
InterPro Database Homepage
Chains
Accession
Name
Type
A
,
B
,
C
,
D
IPR001709
Flavoprotein pyridine nucleotide cytochrome reductase
Domain
A
,
B
,
C
,
D
IPR001433
Oxidoreductase FAD/NAD(P)-binding
Domain
A
,
B
,
C
,
D
IPR001094
Flavodoxin-like
Domain
A
,
B
,
C
,
D
IPR004030
Nitric oxide synthase, N-terminal
Domain
A
,
B
,
C
,
D
IPR023173
NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Homologous Superfamily
A
,
B
,
C
,
D
IPR008254
Flavodoxin/nitric oxide synthase
Domain
A
,
B
,
C
,
D
IPR039261
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Homologous Superfamily
A
,
B
,
C
,
D
IPR017927
FAD-binding domain, ferredoxin reductase-type
Domain
A
,
B
,
C
,
D
IPR036119
Nitric oxide synthase, N-terminal domain superfamily
Homologous Superfamily
A
,
B
,
C
,
D
IPR044944
Nitric oxide synthase, domain 3 superfamily
Homologous Superfamily
A
,
B
,
C
,
D
IPR044943
Nitric oxide synthase, domain 1 superfamily
Homologous Superfamily
A
,
B
,
C
,
D
IPR003097
Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Domain
A
,
B
,
C
,
D
IPR017938
Riboflavin synthase-like beta-barrel
Homologous Superfamily
A
,
B
,
C
,
D
IPR044940
Nitric oxide synthase, domain 2 superfamily
Homologous Superfamily
A
,
B
,
C
,
D
IPR036034
PDZ superfamily
Homologous Superfamily
A
,
B
,
C
,
D
IPR029039
Flavoprotein-like superfamily
Homologous Superfamily
A
,
B
,
C
,
D
IPR050607
Nitric Oxide Synthase (NOS)
Family
A
,
B
,
C
,
D
IPR012144
Nitric-oxide synthase, eukaryote
Family
A
,
B
,
C
,
D
IPR001478
PDZ domain
Domain
Pharos: Disease Associations
Pharos Homepage Annotation
Chains
Drug Target  
Associated Disease
A
,
B
,
C
,
D
Pharos
: 
P29475
hepatic encephalopathy
intestinal perforation
endogenous depression
status epilepticus
Radiation Injuries, Experimental
alcohol-related birth defect
fetal alcohol syndrome
nervous system disorder
visual epilepsy
Parkinson disease
schizophrenia
melancholia
achalasia
cerebellar disease
morphine dependence
hepatic encephalopathy
intestinal perforation
endogenous depression
status epilepticus
Radiation Injuries, Experimental
alcohol-related birth defect
fetal alcohol syndrome
nervous system disorder
visual epilepsy
Parkinson disease
schizophrenia
melancholia
achalasia
cerebellar disease
morphine dependence
amphetamine abuse
fetal alcohol spectrum disorder
hepatic coma
ovarian cancer
idiopathic achalasia
periodontitis
large cell medulloblastoma
primitive neuroectodermal tumor
malignant ependymoma
medulloblastoma
neurotic disorder
atypical teratoid rhabdoid tumor
oligodendroglioma
colorectal cancer
psoriasis
malignant glioma
erectile dysfunction
myopathy
nervous system injury
astrocytic tumor
type 1 diabetes mellitus
osteosarcoma
partial fetal alcohol syndrome
pituitary cancer
depressive disorder
lung carcinoma
psychiatric disorder
Duchenne muscular dystrophy
glioblastoma
chronic liver failure
Less
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