9D4Z | pdb_00009d4z

CryoEM structure of PAR1 with endogenous tethered ligand

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein binding binding enzyme binding GTPase binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity signaling receptor complex adaptor activity protein-macromolecule adaptor activity protein binding binding enzyme binding GTPase binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity signaling receptor complex adaptor activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste developmental process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste developmental process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development system development cell population proliferation cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication response to ketone response to prostaglandin response to lipid response to endogenous stimulus response to alcohol cellular response to prostaglandin stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to prostaglandin E stimulus cellular response to chemical stimulus cellular response to alcohol response to hormone response to chemical cellular response to lipid response to prostaglandin E cellular response to ketone cellular response to hormone stimulus small GTPase-mediated signal transduction Ras protein signal transduction intracellular signal transduction intracellular signaling cassette phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular response to nitrogen compound response to dopamine cellular response to dopamine response to monoamine response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus G protein-coupled dopamine receptor signaling pathway response to nitrogen compound adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to monoamine stimulus adenylate cyclase-modulating G protein-coupled receptor signaling pathway synaptic signaling cellular response to acetylcholine cell-cell signaling acetylcholine receptor signaling pathway postsynaptic signal transduction G protein-coupled acetylcholine receptor signaling pathway response to acetylcholine	cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium neuron projection photoreceptor disc membrane photoreceptor outer segment plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle membrane intracellular anatomical structure cytoplasm cytosol vacuolar membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle lysosomal membrane lysosome synapse cell junction
B [auth G]	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein binding binding G-protein beta-subunit binding	fibroblast proliferation cell population proliferation cellular process cellular response to nitrogen compound cellular response to stimulus response to dopamine regulation of cellular process response to stimulus signaling cellular response to dopamine response to monoamine cell communication response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway fibroblast proliferation cell population proliferation cellular process cellular response to nitrogen compound cellular response to stimulus response to dopamine regulation of cellular process response to stimulus signaling cellular response to dopamine response to monoamine cell communication response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus signal transduction regulation of biological process G protein-coupled dopamine receptor signaling pathway biological regulation response to oxygen-containing compound response to nitrogen compound adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to monoamine stimulus response to chemical adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway response to ketone response to prostaglandin response to lipid response to endogenous stimulus response to alcohol cellular response to prostaglandin stimulus cellular response to endogenous stimulus cellular response to prostaglandin E stimulus cellular response to alcohol response to hormone cellular response to lipid response to prostaglandin E cellular response to ketone cellular response to hormone stimulus	cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction
C [auth R]	Proteinase-activated receptor 1	protein binding binding G-protein alpha-subunit binding signaling receptor binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity peptide receptor activity thrombin-activated receptor activity proteinase-activated receptor activity G protein-coupled peptide receptor activity G-protein beta-subunit binding	negative regulation of protein transport protein localization regulation of systemic arterial blood pressure by renin-angiotensin regulation of localization multicellular organismal process regulation of systemic arterial blood pressure by hormone establishment of protein localization system process nitrogen compound transport regulation of cellular process regulation of renal system process regulation of system process negative regulation of biological process negative regulation of transport cell communication negative regulation of protein transport protein localization regulation of systemic arterial blood pressure by renin-angiotensin regulation of localization multicellular organismal process regulation of systemic arterial blood pressure by hormone establishment of protein localization system process nitrogen compound transport regulation of cellular process regulation of renal system process regulation of system process negative regulation of biological process negative regulation of transport cell communication localization negative regulation of secretion circulatory system process renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure cellular macromolecule localization negative regulation of secretion by cell regulation of biological quality regulation of biological process establishment of protein localization to extracellular region negative regulation of establishment of protein localization regulation of systemic arterial blood pressure by circulatory renin-angiotensin protein secretion establishment of localization regulation of protein secretion regulation of secretion negative regulation of protein secretion regulation of endocrine process renin secretion into blood stream cellular localization regulation of systemic arterial blood pressure mediated by a chemical signal regulation of protein localization transport signaling negative regulation of renin secretion into blood stream protein localization to extracellular region regulation of secretion by cell secretion by cell regulation of renin secretion into blood stream signal release negative regulation of cellular process regulation of multicellular organismal process renal system process involved in regulation of systemic arterial blood pressure blood circulation negative regulation of protein localization renal system process regulation of transport secretion regulation of blood pressure biological regulation regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport endocrine process regulation of systemic arterial blood pressure protein transport regulation of cellular localization macromolecule localization cellular process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells regulation of tube diameter regulation of tube size positive regulation of biological process positive regulation of vasoconstriction regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size cellular response to stimulus response to stimulus thrombin-activated receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process leukocyte homeostasis immune system process dendritic cell homeostasis regulation of body fluid levels wound healing cell activation hemostasis blood coagulation response to stress coagulation response to wounding platelet activation positive regulation of interleukin-8 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process regulation of biosynthetic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of interleukin-8 production phospholipase C-activating G protein-coupled receptor signaling pathway regulation of calcium ion transport positive regulation of calcium ion transport regulation of monoatomic ion transport calcium ion transport metal ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport positive regulation of coagulation regulation of response to external stimulus positive regulation of blood coagulation regulation of response to wounding regulation of coagulation positive regulation of response to stimulus regulation of response to stress positive regulation of hemostasis regulation of hemostasis positive regulation of response to wounding regulation of blood coagulation response to external stimulus positive regulation of wound healing regulation of response to stimulus regulation of wound healing vesicle organization cellular component organization platelet dense granule organization organelle organization secretory granule organization cellular component organization or biogenesis endomembrane system organization regulation of interleukin-1 production interleukin-1 production regulation of interleukin-1 beta production interleukin-1 beta production collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process cell junction organization neuromuscular junction development establishment of synaptic specificity at neuromuscular junction synapse organization positive regulation of cytosolic calcium ion concentration positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity nervous system process sensory perception of pain regulation of nervous system process sensory perception regulation of sensory perception regulation of sensory perception of pain connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response defense response inflammatory response to wounding tissue remodeling connective tissue replacement inflammatory response small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction Rho protein signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction positive regulation of small GTPase mediated signal transduction trans-synaptic signaling trans-synaptic signaling, modulating synaptic transmission modulation of chemical synaptic transmission trans-synaptic signaling by endocannabinoid chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling trans-synaptic signaling by lipid, modulating synaptic transmission anterograde trans-synaptic signaling trans-synaptic signaling by lipid trans-synaptic signaling by endocannabinoid, modulating synaptic transmission regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction developmental process anatomical structure morphogenesis anatomical structure development neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death negative regulation of apoptotic process regulation of neuron apoptotic process negative regulation of glomerular filtration regulation of glomerular filtration renal system process involved in regulation of blood volume negative regulation of multicellular organismal process glomerular filtration renal filtration cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion inorganic ion homeostasis intracellular calcium ion homeostasis monoatomic ion transmembrane transport calcium ion homeostasis negative regulation of sequestering of calcium ion maintenance of location in cell monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport cell surface receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via JAK-STAT cell surface receptor signaling pathway regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT regulation of synaptic plasticity positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription positive regulation of smooth muscle contraction muscle contraction muscle system process regulation of muscle system process smooth muscle contraction regulation of muscle contraction regulation of smooth muscle contraction positive regulation of muscle contraction cell junction maintenance cellular component maintenance cell-cell junction maintenance cell-cell junction organization positive regulation of cation transmembrane transport positive regulation of monoatomic ion transmembrane transport regulation of release of sequestered calcium ion into cytosol regulation of transmembrane transport regulation of monoatomic ion transmembrane transport regulation of calcium ion transmembrane transport positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of release of sequestered calcium ion into cytosol regulation of monoatomic cation transmembrane transport biological process involved in interspecies interaction between organisms response to lipid response to other organism response to oxygen-containing compound response to lipopolysaccharide response to biotic stimulus response to bacterium response to chemical response to external biotic stimulus response to molecule of bacterial origin	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane neuromuscular junction membrane-bounded organelle intracellular organelle intracellular anatomical structure cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane neuromuscular junction membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cell surface membrane microdomain membrane raft plasma membrane raft caveola early endosome endosome intracellular vesicle cytoplasmic vesicle vesicle extracellular region platelet dense tubular network late endosome
D [auth E]	scFv16	-	-	-
E [auth A]	Guanine nucleotide-binding protein G(q) subunit alpha chimera	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR019775	WD40 repeat, conserved site	Conserved Site
A [auth B]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A [auth B]	IPR016346	Guanine nucleotide-binding protein, beta subunit	Family
A [auth B]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A [auth B]	IPR001632	G-protein, beta subunit	Domain
A [auth B]	IPR001680	WD40 repeat	Repeat
A [auth B]	IPR020472	G-protein beta WD-40 repeat	Repeat
B [auth G]	IPR015898	G-protein gamma-like domain	Domain
B [auth G]	IPR001770	G-protein, gamma subunit	Family
B [auth G]	IPR036284	G-protein gamma-like domain superfamily	Homologous Superfamily
C [auth R]	IPR000935	Thrombin receptor	Family
C [auth R]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
C [auth R]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
C [auth R]	IPR003912	Protease-activated receptor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: P62873	intellectual disability, autosomal dominant 42 melancholia intellectual disability endogenous depression medulloblastoma myopathy ovarian cancer Precursor Cell Lymphoblastic Leukemia Lymphoma anxiety disorder Sjogren syndrome chronic kidney disease juvenile dermatomyositis lung adenocarcinoma neurotic disorder pancreatic ductal adenocarcinoma intellectual disability, autosomal dominant 42 melancholia intellectual disability endogenous depression medulloblastoma myopathy ovarian cancer Precursor Cell Lymphoblastic Leukemia Lymphoma anxiety disorder Sjogren syndrome chronic kidney disease juvenile dermatomyositis lung adenocarcinoma neurotic disorder pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma breast cancer Duchenne muscular dystrophy leukemia, acute lymphocytic, susceptibility to, 1 malignant pancreatic neoplasm myelodysplastic syndrome osteosarcoma plasma cell myeloma rheumatoid arthritis swine influenza childhood acute lymphoblastic leukemia depressive disorder
B [auth G]	Pharos: P59768	pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma sarcoidosis ulcerative colitis adrenal cortex carcinoma breast carcinoma Duchenne muscular dystrophy glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer Sjogren syndrome X-linked mixed deafness with perilymphatic gusher pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma sarcoidosis ulcerative colitis adrenal cortex carcinoma breast carcinoma Duchenne muscular dystrophy glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer Sjogren syndrome X-linked mixed deafness with perilymphatic gusher astrocytic tumor Crohn disease ductal breast carcinoma in situ interstitial cystitis lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma Pick disease primitive neuroectodermal tumor thoracic aortic aneurysm atypical teratoid rhabdoid tumor cystic fibrosis Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma malignant ependymoma osteosarcoma
C [auth R]	Pharos: P25116	Neoplasms, Experimental gastric cancer cirrhosis of liver hepatitis malignant ependymoma medulloblastoma ovarian cancer primitive neuroectodermal tumor acute myeloid leukemia thrombotic disease glioblastoma hereditary diffuse gastric adenocarcinoma large cell medulloblastoma malignant glioma oligodendroglioma Neoplasms, Experimental gastric cancer cirrhosis of liver hepatitis malignant ependymoma medulloblastoma ovarian cancer primitive neuroectodermal tumor acute myeloid leukemia thrombotic disease glioblastoma hereditary diffuse gastric adenocarcinoma large cell medulloblastoma malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma Sjogren syndrome astrocytic tumor ulcerative colitis fatty liver disease gastric carcinoma head and neck cancer nasopharyngeal carcinoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor esophageal adenocarcinoma gastric neoplasm interstitial cystitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.