9DNX | pdb_00009dnx

Human ClC-3:TMEM9, TMEM9 Protomer A and B: Complete

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth C]	PF00571	CBS domain (CBS)	CBS domain	CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands ...	CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [5]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet [4]. CBS domain pairs from AMPK bind AMP or ATP [5]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [5].	Domain
A, D [auth C]	PF00654	Voltage gated chloride channel (Voltage_CLC)	Voltage gated chloride channel	-	Family
B [auth D], C [auth B]	PF05434	TMEM9 (Tmemb_9)	TMEM9	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth C]	H(+)/Cl(-) exchange transporter 3	volume-sensitive chloride channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic ion channel activity volume-sensitive anion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity volume-sensitive chloride channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic ion channel activity volume-sensitive anion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity antiporter activity active transmembrane transporter activity secondary active transmembrane transporter activity protein binding binding PDZ domain binding protein domain specific binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding voltage-gated chloride channel activity gated channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic anion channel activity	membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport chloride transport transmembrane transport chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport chemical homeostasis homeostatic process regulation of pH biological regulation monoatomic ion homeostasis monoatomic cation homeostasis intracellular pH reduction regulation of intracellular pH vesicle organization organelle organization cellular homeostasis intracellular monoatomic cation homeostasis endosome organization intracellular chemical homeostasis regulation of biological quality endosomal lumen acidification endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis regulation of cellular component size cell volume homeostasis negative regulation of cell volume regulation of cell size regulation of anatomical structure size multicellular organismal-level homeostasis anatomical structure homeostasis tissue homeostasis retina homeostasis photoreceptor cell maintenance synaptic vesicle maturation cellular localization synaptic vesicle cycle vesicle-mediated transport in synapse monoatomic cation transmembrane transport establishment of localization in cell synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport developmental maturation inorganic cation transmembrane transport neuron cellular homeostasis reactive oxygen species biosynthetic process regulation of biosynthetic process regulation of biological process regulation of cellular process positive regulation of reactive oxygen species biosynthetic process reactive oxygen species metabolic process positive regulation of biological process regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species metabolic process positive regulation of metabolic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of metabolic process positive regulation of cellular process regulation of reactive oxygen species metabolic process trans-synaptic signaling synaptic transmission, GABAergic signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling synaptic transmission, glutamatergic	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane ruffle cell leading edge leading edge membrane plasma membrane bounded cell projection cell projection ruffle membrane plasma membrane region cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane ruffle cell leading edge leading edge membrane plasma membrane bounded cell projection cell projection ruffle membrane plasma membrane region cell projection membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endocytic vesicle endomembrane system secretory granule secretory vesicle endosome membrane endosome late endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane late endosome organelle membrane GABA-ergic synapse synapse cell junction glutamatergic synapse early endosome vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus Golgi membrane early endosome membrane recycling endosome transport vesicle membrane presynapse synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane exocytic vesicle specific granule axon neuron projection axon terminus distal axon neuron projection terminus
B [auth D], C [auth B]	Proton-transporting V-type ATPase complex assembly regulator TMEM9	-	homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality monoatomic cation homeostasis homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality monoatomic cation homeostasis regulation of lysosomal lumen pH regulation of cellular pH intracellular monoatomic ion homeostasis vacuole organization lytic vacuole organization biological regulation organelle organization cellular homeostasis chemical homeostasis cellular process regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process positive regulation of canonical Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling vesicle organization endosome organization endosomal lumen acidification endomembrane system organization proton-transporting V-type ATPase complex assembly cellular component biogenesis cellular component assembly protein-containing complex organization proton-transporting two-sector ATPase complex assembly protein-containing complex assembly	intercellular bridge cellular anatomical structure vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane intercellular bridge cellular anatomical structure vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane cytoplasm organelle membrane lysosome endosome membrane endosome multivesicular body membrane intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane late endosome vesicle multivesicular body mitotic spindle cytoskeleton spindle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth C]	IPR046342	CBS domain superfamily	Homologous Superfamily
A, D [auth C]	IPR002245	H(+)/Cl(-) exchange transporter 3	Family
A, D [auth C]	IPR001807	Chloride channel	Family
A, D [auth C]	IPR014743	Chloride channel, core	Homologous Superfamily
A, D [auth C]	IPR000644	CBS domain	Domain
B [auth D], C [auth B]	IPR008853	TMEM9/TMEM9B	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D [auth C]	Pharos: P51790	mixed glioma nasopharyngeal carcinoma malignant glioma gastric cancer malignant mesothelioma ovarian cancer plasma cell myeloma acute myeloid leukemia spina bifida autism spectrum disorder epilepsy gastric carcinoma hepatocellular carcinoma interstitial cystitis lung carcinoma mixed glioma nasopharyngeal carcinoma malignant glioma gastric cancer malignant mesothelioma ovarian cancer plasma cell myeloma acute myeloid leukemia spina bifida autism spectrum disorder epilepsy gastric carcinoma hepatocellular carcinoma interstitial cystitis lung carcinoma Malignant neoplasm of stomach pancreatic intraductal papillary-mucinous carcinoma psoriasis adenoma tuberculosis exocrine pancreatic carcinoma gastric neoplasm hereditary diffuse gastric adenocarcinoma lung adenocarcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia rheumatoid arthritis astrocytic tumor glioma hereditary spastic paraplegia lung cancer
B [auth D], C [auth B]	Pharos: Q9P0T7	osteosarcoma tooth agenesis ovarian cancer primary biliary cholangitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.