Annotations: 9EIH

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth E], D [auth F]	PF01459	Eukaryotic porin (Porin_3)	Eukaryotic porin	-	Family
E [auth G], F [auth H], G [auth I], H [auth J]	PF01459	Eukaryotic porin (Porin_3)	Eukaryotic porin	-	Family
I [auth K], J [auth L], W [auth Y], X [auth Z]	PF10642	Mitochondrial import receptor subunit or translocase (Tom5)	Mitochondrial import receptor subunit or translocase	-	Family
K [auth M], L [auth N], U [auth W], V [auth X]	PF08038	TOM7 family (Tom7)	TOM7 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D]	Mitochondrial import receptor subunit TOM20 homolog	signal sequence binding binding peptide binding mitochondrion targeting sequence binding unfolded protein binding protein binding macromolecule transmembrane transporter activity active transmembrane transporter activity protein transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity protein transmembrane transporter activity protein-transporting ATPase activity transporter activity signal sequence binding binding peptide binding mitochondrion targeting sequence binding unfolded protein binding protein binding macromolecule transmembrane transporter activity active transmembrane transporter activity protein transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity protein transmembrane transporter activity protein-transporting ATPase activity transporter activity transmembrane transporter activity ATP-dependent activity	response to stimulus response to activity response to muscle activity protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion response to stimulus response to activity response to muscle activity protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion response to 3,3',5-triiodo-L-thyronine response to acid chemical response to chemical response to oxygen-containing compound response to nitrogen compound response to amino acid nitrogen compound transport transport establishment of protein localization to mitochondrial membrane mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization establishment of localization in cell cellular component organization or biogenesis mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane intracellular transport localization within membrane protein localization to membrane organelle organization protein transport intracellular protein transport protein transmembrane import into intracellular organelle protein import into mitochondrial matrix protein transmembrane transport mitochondrial transmembrane transport transmembrane transport import into the mitochondrion RNA transport nucleic acid transport tRNA transport RNA import into mitochondrion establishment of RNA localization tRNA import into mitochondrion RNA localization nucleobase-containing compound transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle membrane contact site mitochondria-associated endoplasmic reticulum membrane contact site mitochondrial protein-containing complex protein-containing complex mitochondrial membrane outer mitochondrial membrane protein complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle membrane contact site mitochondria-associated endoplasmic reticulum membrane contact site mitochondrial protein-containing complex protein-containing complex mitochondrial membrane outer mitochondrial membrane protein complex membrane membrane protein complex organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane mitochondrial outer membrane translocase complex outer membrane organelle membrane cell periphery cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection TOM complex migrasome
C [auth E], D [auth F]	Non-selective voltage-gated ion channel VDAC2	sterol binding binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding amide binding ceramide binding sphingolipid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding sterol binding binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding amide binding ceramide binding sphingolipid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity oxysterol binding lipid transporter activity intramembrane lipid transporter activity phospholipid scramblase activity phospholipid transporter activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity monoatomic ion transmembrane transporter activity cation binding phosphatidylcholine binding phospholipid binding quaternary ammonium group binding monoatomic anion transmembrane transporter activity voltage-gated monoatomic anion channel activity monoatomic anion channel activity	protein polymerization regulation of biological process regulation of cellular process regulation of cellular component organization negative regulation of cellular component organization protein-containing complex organization biological regulation negative regulation of biological process regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly regulation of protein polymerization protein polymerization regulation of biological process regulation of cellular process regulation of cellular component organization negative regulation of cellular component organization protein-containing complex organization biological regulation negative regulation of biological process regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly regulation of protein polymerization protein-containing complex assembly negative regulation of cellular process negative regulation of protein polymerization cellular process cellular component organization or biogenesis localization transport monoatomic anion transport monoatomic ion transport establishment of localization cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway signal transduction intrinsic apoptotic signaling pathway regulation of signaling negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction negative regulation of intrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway transmembrane transport mitochondrial transmembrane transport mitochondrial transport apoptotic mitochondrial changes mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability regulation of biological quality regulation of mitochondrial membrane permeability mitochondrion organization membrane organization organelle organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process mitochondrial outer membrane permeabilization sperm-egg recognition sexual reproduction cell-cell recognition reproductive process fertilization binding of sperm to zona pellucida cell recognition single fertilization phospholipid translocation lipid localization phospholipid transport lipid transport lipid translocation regulation of membrane lipid distribution macromolecule localization organophosphate ester transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane mitochondrial membrane organelle envelope mitochondrial envelope organelle membrane membrane microdomain membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane mitochondrial membrane organelle envelope mitochondrial envelope organelle membrane membrane microdomain membrane raft cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection organelle outer membrane bounding membrane of organelle mitochondrial outer membrane outer membrane membrane-enclosed lumen intracellular membraneless organelle nucleoid mitochondrial matrix intracellular organelle lumen organelle lumen membraneless organelle mitochondrial nucleoid protein-containing complex pore complex membrane protein complex nucleus acrosomal vesicle intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle
E [auth G], F [auth H], G [auth I], H [auth J]	Mitochondrial import receptor subunit TOM40 homolog	wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity	protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion transport monoatomic ion transport nitrogen compound transport establishment of protein localization to mitochondrial membrane mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization establishment of localization in cell cellular component organization or biogenesis mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane intracellular transport localization within membrane protein localization to membrane organelle organization protein transport intracellular protein transport protein transmembrane import into intracellular organelle protein import into mitochondrial matrix protein transmembrane transport mitochondrial transmembrane transport transmembrane transport import into the mitochondrion	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle membrane contact site mitochondria-associated endoplasmic reticulum membrane contact site mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle membrane contact site mitochondria-associated endoplasmic reticulum membrane contact site mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial protein-containing complex protein-containing complex outer mitochondrial membrane protein complex membrane protein complex organelle outer membrane bounding membrane of organelle mitochondrial outer membrane mitochondrial outer membrane translocase complex outer membrane cytosol pore complex TOM complex
I [auth K], J [auth L], W [auth Y], X [auth Z]	Mitochondrial import receptor subunit TOM5 homolog	-	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane intracellular transport localization within membrane protein localization to membrane establishment of localization organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion intracellular protein transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane mitochondrial protein-containing complex protein-containing complex outer mitochondrial membrane protein complex membrane protein complex mitochondrial outer membrane translocase complex TOM complex
K [auth M], L [auth N], U [auth W], V [auth X]	Mitochondrial import receptor subunit TOM7 homolog	macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane intracellular transport localization within membrane protein localization to membrane establishment of localization organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion intracellular protein transport regulation of protein stability biological regulation regulation of biological quality catabolic process regulation of cellular process regulation of type 2 mitophagy macroautophagy positive regulation of type 2 mitophagy autophagy positive regulation of biological process regulation of autophagy positive regulation of autophagy of mitochondrion positive regulation of metabolic process mitophagy regulation of autophagy of mitochondrion positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of cellular process positive regulation of autophagy regulation of biological process positive regulation of mitophagy regulation of mitophagy regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy type 2 mitophagy metabolic process regulation of metabolic process autophagy of mitochondrion protein transmembrane import into intracellular organelle protein import into mitochondrial matrix protein transmembrane transport mitochondrial transmembrane transport transmembrane transport import into the mitochondrion regulation of localization regulation of protein localization regulation of protein targeting to mitochondrion positive regulation of establishment of protein localization positive regulation of protein targeting to mitochondrion regulation of establishment of protein localization regulation of establishment of protein localization to mitochondrion regulation of protein targeting regulation of cellular localization positive regulation of protein localization positive regulation of establishment of protein localization to mitochondrion	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane mitochondrial protein-containing complex protein-containing complex outer mitochondrial membrane protein complex membrane protein complex mitochondrial outer membrane translocase complex TOM complex
M [auth O], N [auth P], S [auth U], T [auth V]	Mitochondrial import receptor subunit TOM6 homolog	-	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane intracellular transport localization within membrane protein localization to membrane establishment of localization organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion intracellular protein transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane protein-containing complex membrane protein complex mitochondrial protein-containing complex TOM complex outer mitochondrial membrane protein complex mitochondrial outer membrane translocase complex
O [auth Q], P [auth R], Q [auth S], R [auth T]	Mitochondrial import receptor subunit TOM22 homolog	signal sequence binding binding peptide binding mitochondrion targeting sequence binding macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane intracellular transport localization within membrane protein localization to membrane establishment of localization organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion intracellular protein transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane mitochondrial protein-containing complex protein-containing complex outer mitochondrial membrane protein complex membrane protein complex mitochondrial outer membrane translocase complex TOM complex
Y [auth A], Z [auth B]	Serine/threonine-protein kinase PINK1, mitochondrial	protein binding binding protein kinase B binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor protein binding binding protein kinase B binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding enzyme regulator activity peptidase activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity hydrolase activity peptidase activator activity protein-containing complex binding histone H3T6 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding histone H3S57 kinase activity protease binding histone H4S1 kinase activity histone H4 kinase activity cation binding magnesium ion binding metal ion binding histone H3T11 kinase activity histone H3S28 kinase activity histone H2B kinase activity histone H2BS36 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity histone H2AS121 kinase activity histone H2A kinase activity C3HC4-type RING finger domain binding protein domain specific binding AMP-activated protein kinase activity histone H3T45 kinase activity eukaryotic translation initiation factor 2alpha kinase activity histone H3T3 kinase activity histone H2BS14 kinase activity Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity protein serine kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2AS1 kinase activity	catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion biological regulation regulation of mitophagy regulation of catabolic process negative regulation of mitophagy negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy cellular process metabolic process regulation of metabolic process autophagy of mitochondrion regulation of protein stability regulation of biological quality protein stabilization response to stimulus response to stress response to ischemia positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation macromolecule metabolic process developmental process cellular developmental process hemopoiesis cell differentiation anatomical structure development cell development cellular response to stimulus response to oxidative stress cellular response to chemical stimulus cellular response to stress response to chemical cellular response to oxidative stress cellular response to chemical stress protein localization regulation of localization establishment of protein localization cellular localization regulation of protein localization protein targeting regulation of protein targeting to mitochondrion localization cellular macromolecule localization regulation of establishment of protein localization establishment of localization regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle regulation of protein targeting regulation of cellular localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration regulation of aerobic respiration regulation of oxidative phosphorylation reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process cellular response to toxic substance response to toxic substance regulation of cellular component organization positive regulation of cellular component organization homeostatic process cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly positive regulation of protein polymerization protein-containing complex assembly cellular component organization or biogenesis protein polymerization protein-containing complex organization positive regulation of cellular component biogenesis free ubiquitin chain polymerization regulation of free ubiquitin chain polymerization regulation of cellular component biogenesis cellular homeostasis positive regulation of free ubiquitin chain polymerization regulation of protein polymerization ubiquitin recycling regulation of hydrogen peroxide-mediated programmed cell death negative regulation of neuron apoptotic process programmed cell death in response to reactive oxygen species regulation of signal transduction regulation of programmed cell death intracellular signal transduction cell communication negative regulation of apoptotic signaling pathway signal transduction intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of programmed cell death regulation of apoptotic process cell death cellular response to oxygen-containing compound negative regulation of apoptotic process regulation of response to stimulus regulation of neuron apoptotic process regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide regulation of oxidative stress-induced intrinsic apoptotic signaling pathway signaling negative regulation of signaling negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of hydrogen peroxide-mediated programmed cell death cellular response to reactive oxygen species hydrogen peroxide-mediated programmed cell death regulation of intracellular signal transduction regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway regulation of signaling negative regulation of response to stimulus response to oxygen-containing compound negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of signal transduction response to reactive oxygen species neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of cell communication apoptotic process programmed cell death regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction positive regulation of response to stimulus intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of signaling aerobic electron transport chain ATP synthesis coupled electron transport electron transport chain positive regulation of cellular respiration respiratory electron transport chain mitochondrial electron transport, NADH to ubiquinone regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of mitochondrial electron transport, NADH to ubiquinone mitochondrial ATP synthesis coupled electron transport regulation of mitochondrial membrane potential regulation of membrane potential regulation of catalytic activity regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification positive regulation of molecular function protein ubiquitination regulation of ubiquitin-protein transferase activity regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination positive regulation of transferase activity regulation of post-translational protein modification positive regulation of catalytic activity positive regulation of ubiquitin-protein transferase activity regulation of molecular function post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of cellular response to stress regulation of cellular response to oxidative stress regulation of response to stress regulation of response to oxidative stress regulation of hydrogen peroxide metabolic process hydrogen peroxide metabolic process positive regulation of establishment of protein localization positive regulation of protein targeting to mitochondrion positive regulation of protein localization positive regulation of establishment of protein localization to mitochondrion positive regulation of autophagy positive regulation of catabolic process positive regulation of macroautophagy positive regulation of organelle organization regulation of developmental process positive regulation of developmental process regulation of anatomical structure morphogenesis mitochondrion organization organelle fission mitochondrial fission regulation of organelle organization anatomical structure morphogenesis organelle organization regulation of mitochondrial fission regulation of mitochondrion organization positive regulation of mitochondrial fission positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion negative regulation of organelle assembly autophagosome organization negative regulation of autophagosome assembly autophagosome assembly organelle assembly vacuole organization negative regulation of cellular component organization regulation of autophagosome assembly regulation of vacuole organization negative regulation of organelle organization regulation of organelle assembly regulation of biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process maintenance of protein location maintenance of protein location in mitochondrion maintenance of location maintenance of location in cell maintenance of protein location in cell maintenance of protein localization in organelle monoamine transport nitrogen compound transport transport secretion export from cell cell-cell signaling organic hydroxy compound transport dopamine secretion dopamine transport catecholamine secretion secretion by cell catecholamine transport signal release cellular response to hydrogen sulfide response to hydrogen sulfide negative regulation of developmental process negative regulation of mitochondrial fission apoptotic mitochondrial changes regulation of release of cytochrome c from mitochondria positive regulation of release of cytochrome c from mitochondria release of cytochrome c from mitochondria intracellular transport mitochondrion to lysosome vesicle-mediated transport lysosomal transport vesicle-mediated transport mitochondrion-derived vesicle mediated transport establishment of localization in cell vacuolar transport mitochondrial transport response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus regulation of type 2 mitophagy positive regulation of type 2 mitophagy positive regulation of autophagy of mitochondrion positive regulation of mitophagy type 2 mitophagy vesicle localization establishment of organelle localization regulation of transport establishment of vesicle localization regulation of synaptic vesicle transport organelle localization synaptic vesicle localization synaptic vesicle transport TOR signaling TORC2 signaling regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteasomal protein catabolic process regulation of proteasomal protein catabolic process regulation of protein catabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process positive regulation of nucleotide biosynthetic process regulation of nucleotide biosynthetic process regulation of ATP metabolic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside triphosphate biosynthetic process regulation of small molecule metabolic process positive regulation of purine nucleotide biosynthetic process regulation of nucleotide metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process positive regulation of nucleobase-containing compound metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process ribonucleoside triphosphate biosynthetic process positive regulation of ATP metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process positive regulation of biosynthetic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine-containing compound biosynthetic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process carbohydrate derivative biosynthetic process regulation of purine nucleotide biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of ATP biosynthetic process regulation of ATP biosynthetic process organophosphate metabolic process positive regulation of small molecule metabolic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription intrinsic apoptotic signaling pathway in response to hypoxia regulation of cellular response to hypoxia regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of cellular response to hypoxia negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway membrane organization cristae formation inner mitochondrial membrane organization regulation of cristae formation mitochondrial membrane organization positive regulation of cristae formation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of catecholamine secretion positive regulation of secretion by cell positive regulation of amine transport regulation of secretion by cell positive regulation of secretion positive regulation of catecholamine secretion positive regulation of dopamine secretion regulation of secretion amine transport positive regulation of transport regulation of amine transport regulation of dopamine secretion negative regulation of JNK cascade JNK cascade regulation of JNK cascade regulation of MAPK cascade MAPK cascade negative regulation of MAPK cascade positive regulation of translation post-transcriptional regulation of gene expression translation positive regulation of gene expression regulation of translation modulation of chemical synaptic transmission synaptic signaling trans-synaptic signaling positive regulation of synaptic transmission regulation of synaptic transmission, dopaminergic chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling positive regulation of synaptic transmission, dopaminergic synaptic transmission, dopaminergic protein autophosphorylation peptidyl-serine autophosphorylation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell body membrane-bounded organelle mitochondrial intermembrane space mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell body membrane-bounded organelle mitochondrial intermembrane space mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen organelle mitochondrial envelope mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle membrane glial cell projection cell projection plasma membrane bounded cell projection astrocyte projection inclusion body Lewy body membraneless organelle intracellular membraneless organelle chromatin chromosome cytoskeleton perinuclear region of cytoplasm organelle outer membrane bounding membrane of organelle mitochondrial outer membrane outer membrane axon neuron projection growth cone distal axon site of polarized growth nucleus endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth D]	IPR023392	Mitochondrial outer membrane translocase complex, Tom20 domain superfamily	Homologous Superfamily
A [auth C], B [auth D]	IPR022422	Protein import receptor MAS20, metazoan	Family
A [auth C], B [auth D]	IPR002056	Protein import receptor MAS20	Family
C [auth E], D [auth F]	IPR023614	Porin domain superfamily	Homologous Superfamily
C [auth E], D [auth F]	IPR001925	Porin, eukaryotic type	Family
C [auth E], D [auth F]	IPR027246	Eukaryotic porin/Tom40	Family
E [auth G], F [auth H], G [auth I], H [auth J]	IPR023614	Porin domain superfamily	Homologous Superfamily
E [auth G], F [auth H], G [auth I], H [auth J]	IPR037930	Tom40	Family
E [auth G], F [auth H], G [auth I], H [auth J]	IPR027246	Eukaryotic porin/Tom40	Family
I [auth K], J [auth L], W [auth Y], X [auth Z]	IPR019603	Mitochondrial outer membrane translocase complex, subunit Tom5	Family
I [auth K], J [auth L], W [auth Y], X [auth Z]	IPR029179	Mitochondrial import receptor subunit TOM5, metazoa	Family
K [auth M], L [auth N], U [auth W], V [auth X]	IPR012621	Mitochondrial import receptor subunit TOM7	Family
M [auth O], N [auth P], S [auth U], T [auth V]	IPR029182	Mitochondrial import receptor subunit TOM6 homologue	Family
O [auth Q], P [auth R], Q [auth S], R [auth T]	IPR005683	Mitochondrial import receptor subunit Tom22	Family
Y [auth A], Z [auth B]	IPR000719	Protein kinase domain	Domain
Y [auth A], Z [auth B]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
Y [auth A], Z [auth B]	IPR040110	PINK1, protein kinase domain	Domain
Y [auth A], Z [auth B]	IPR051511	Mitochondrial Quality Control and Scaffold Kinases	Family
Y [auth A], Z [auth B]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], B [auth D]	Pharos: Q15388	atypical teratoid rhabdoid tumor malignant ependymoma psoriasis glioblastoma ovarian cancer lung cancer plasma cell myeloma
C [auth E], D [auth F]	Pharos: P45880	squamous cell carcinoma epilepsy Aura oral cavity neoplasm osteoarthritis diabetic kidney disease osteoarthritis susceptibility 1
E [auth G], F [auth H], G [auth I], H [auth J]	Pharos: O96008	Alzheimer disease metabolic syndrome X wet macular degeneration abdominal aortic aneurysm Familial Alzheimer Disease (FAD) lung adenocarcinoma malignant mesothelioma non-alcoholic fatty liver disease cerebrovascular disorder heart disease lung cancer vascular dementia age-related macular degeneration Lewy body dementia major depressive disorder Alzheimer disease metabolic syndrome X wet macular degeneration abdominal aortic aneurysm Familial Alzheimer Disease (FAD) lung adenocarcinoma malignant mesothelioma non-alcoholic fatty liver disease cerebrovascular disorder heart disease lung cancer vascular dementia age-related macular degeneration Lewy body dementia major depressive disorder myocardial infarction
K [auth M], L [auth N], U [auth W], V [auth X]	Pharos: Q9P0U1	aortic stenosis ovarian cancer Takayasu arteritis juvenile idiopathic arthritis peripheral arterial disease lung cancer plasma cell myeloma
M [auth O], N [auth P], S [auth U], T [auth V]	Pharos: Q96B49	colorectal cancer
O [auth Q], P [auth R], Q [auth S], R [auth T]	Pharos: Q9NS69	atypical teratoid rhabdoid tumor medulloblastoma prostate carcinoma breast cancer osteosarcoma Sjogren syndrome diabetes mellitus pituitary cancer
Y [auth A], Z [auth B]	Pharos: Q9BXM7	Parkinson disease neuroblastoma glioblastoma autosomal recessive early-onset Parkinson disease 6 Nerve Degeneration parkinsonian disorder peripheral neuropathy Alzheimer disease schizophrenia major depressive disorder medulloblastoma neurodegenerative disease primitive neuroectodermal tumor atypical teratoid rhabdoid tumor spina bifida Parkinson disease neuroblastoma glioblastoma autosomal recessive early-onset Parkinson disease 6 Nerve Degeneration parkinsonian disorder peripheral neuropathy Alzheimer disease schizophrenia major depressive disorder medulloblastoma neurodegenerative disease primitive neuroectodermal tumor atypical teratoid rhabdoid tumor spina bifida esophageal adenocarcinoma intellectual disability malignant colon neoplasm osteosarcoma peripheral nervous system disease autosomal recessive juvenile Parkinson disease 2 large cell medulloblastoma malignant glioma

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth C], B [auth D], C [auth E], D [auth F], E [auth G] A [auth C], B [auth D], C [auth E], D [auth F], E [auth G], F [auth H], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N], M [auth O], N [auth P], O [auth Q], P [auth R], Q [auth S], R [auth T], S [auth U], T [auth V], U [auth W], V [auth X], W [auth Y], X [auth Z], Y [auth A], Z [auth B]	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.