Annotations: 9G71

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF04906	Tweety (Tweety)	Tweety	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein tweety homolog 2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding volume-sensitive chloride channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic ion channel activity volume-sensitive anion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding volume-sensitive chloride channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic ion channel activity volume-sensitive anion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity gated channel activity intracellularly calcium-gated channel activity intracellularly calcium-gated chloride channel activity ligand-gated monoatomic anion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity	organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport amino acid transmembrane transport L-amino acid transport establishment of localization L-glutamate import organic acid transport transmembrane transport amino acid transport localization acidic amino acid transport organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport amino acid transmembrane transport L-amino acid transport establishment of localization L-glutamate import organic acid transport transmembrane transport amino acid transport localization acidic amino acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport cellular process L-glutamate transmembrane transport	protein-containing complex cellular anatomical structure transmembrane transporter complex membrane chloride channel complex membrane protein complex transporter complex monoatomic ion channel complex cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006990	Tweety	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9BSA4	astrocytic tumor oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous carcinoma Pick disease subependymal giant cell astrocytoma lung carcinoma pancreatic intraductal papillary-mucinous neoplasm progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.