9GLR | pdb_00009glr

Crystal Structure of Human UBC9 C93E

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA]	SUMO-conjugating enzyme UBC9	protein binding binding small protein activating enzyme binding enzyme binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity SUMO conjugating enzyme activity SUMO transferase activity ubiquitin-like protein conjugating enzyme activity transferase activity catalytic activity RING-like zinc finger domain binding protein binding binding small protein activating enzyme binding enzyme binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity SUMO conjugating enzyme activity SUMO transferase activity ubiquitin-like protein conjugating enzyme activity transferase activity catalytic activity RING-like zinc finger domain binding protein domain specific binding RNA binding nucleic acid binding transcription factor binding transcription coregulator binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process positive regulation of molecular function regulation of molecular function positive regulation of transferase activity regulation of catalytic activity positive regulation of catalytic activity regulation of transferase activity positive regulation of SUMO transferase activity macromolecule modification protein metabolic process protein modification process cell division cell cycle chromosome segregation cell cycle process peptidyl-lysine modification protein sumoylation peptidyl-amino acid modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal mitotic nuclear membrane reassembly membrane biogenesis mitotic cell cycle nuclear membrane reassembly cellular component organization cellular component biogenesis cellular component assembly cellular component organization or biogenesis endomembrane system organization membrane organization mitotic nuclear division organelle fission nuclear membrane organization membrane assembly nuclear division organelle organization nucleus organization mitotic cell cycle process mitotic nuclear membrane organization nuclear envelope organization catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport nuclear export establishment of localization positive regulation of locomotion regulation of cell motility positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol protein-containing complex nuclear protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol protein-containing complex nuclear protein-containing complex nuclear pore membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen catalytic complex SUMO ligase complex transferase complex condensed nuclear chromosome intracellular membraneless organelle nuclear chromosome chromosome membraneless organelle synaptonemal structure synaptonemal complex condensed chromosome perinuclear region of cytoplasm nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA]	IPR050113	Ubiquitin-conjugating enzyme	Family
A [auth AAA]	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
A [auth AAA]	IPR023313	Ubiquitin-conjugating enzyme, active site	Active Site
A [auth AAA]	IPR000608	Ubiquitin-conjugating enzyme E2, catalytic core domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA]	Pharos: P63279	sarcomatoid carcinoma carcinoma Mammary Neoplasms, Experimental psoriasis undifferentiated carcinoma breast cancer glioblastoma lung cancer mammary neoplasms, animal non-small cell lung carcinoma pituitary cancer invasive ductal breast carcinoma lymphoplasmacytic lymphoma osteosarcoma plasma cell myeloma sarcomatoid carcinoma carcinoma Mammary Neoplasms, Experimental psoriasis undifferentiated carcinoma breast cancer glioblastoma lung cancer mammary neoplasms, animal non-small cell lung carcinoma pituitary cancer invasive ductal breast carcinoma lymphoplasmacytic lymphoma osteosarcoma plasma cell myeloma tuberculosis atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.