9HFT | pdb_00009hft

Cryo-EM structure of human CDADC1 inactive mutant (E400A): hexamer with 5mdCTP bound in the active site

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00383	Cytidine and deoxycytidylate deaminase zinc-binding region (dCMP_cyt_deam_1)	Cytidine and deoxycytidylate deaminase zinc-binding region		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Cytidine and dCMP deaminase domain-containing protein 1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines cytidine deaminase activity hydrolase activity catalytic activity deaminase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds dCMP deaminase activity importin-alpha family protein binding cation binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines cytidine deaminase activity hydrolase activity catalytic activity deaminase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds dCMP deaminase activity importin-alpha family protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	DNA cytosine deamination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA deamination DNA modification macromolecule modification metabolic process cellular process macromolecule metabolic process glycosyl compound metabolic process catabolic process pyrimidine-containing compound catabolic process DNA cytosine deamination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA deamination DNA modification macromolecule modification metabolic process cellular process macromolecule metabolic process glycosyl compound metabolic process catabolic process pyrimidine-containing compound catabolic process carbohydrate derivative metabolic process pyrimidine nucleoside metabolic process nucleobase-containing small molecule metabolic process small molecule metabolic process cytidine deamination carbohydrate derivative catabolic process pyrimidine-containing compound metabolic process pyrimidine nucleoside catabolic process cytidine metabolic process glycosyl compound catabolic process nucleoside metabolic process nucleobase-containing compound catabolic process cytidine catabolic process pyrimidine ribonucleoside metabolic process nucleobase-containing small molecule catabolic process nucleoside catabolic process pyrimidine ribonucleoside catabolic process small molecule catabolic process ribonucleoside catabolic process ribonucleoside metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR035105	Deoxycytidylate deaminase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016193	Cytidine deaminase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR015517	Deoxycytidylate deaminase-related	Family
A, B, C, D, E A, B, C, D, E, F	IPR002125	Cytidine and deoxycytidylate deaminase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016192	APOBEC/CMP deaminase, zinc-binding	Binding Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9BWV3	astrocytic tumor large cell medulloblastoma ovarian cancer atypical teratoid rhabdoid tumor malignant glioma glioblastoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.